DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and RGA1

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_014770.1	Gene:	RGA1 / 854294	SGDID:	S000005653	Length:	1007	Species:	Saccharomyces cerevisiae

Alignment Length:	1031	Identity:	204/1031 - (19%)
Similarity:	351/1031 - (34%)	Gaps:	313/1031 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   557 SSTAPGSVCHQ-HQQQQQHHLYHQQQHQQLQQT--QHRQVMINNNAKYAKDLDYFETLQETGVTN 618
            :.|..|..|.. |::......|::::.::|::.  .....:|:|.  :..::.....|.|
Yeast   111 AKTKRGLFCLSCHEKLLAKRKYYEEKKRRLKKNLPSLPTPVIDNG--HTDEVSASAVLPE----- 168

  Fly   619 KVFER--KLVSHMSKGFDPFKPLSINTSAL------------ESSAST----------------S 653
            |.|.|  .||:.:..|.:|.|.:..|:|.:            ::|.|:                |
Yeast   169 KTFSRPASLVNEIPSGSEPSKDIETNSSDIVPHFITGYNDSDDNSGSSKFGSNVSIDVIGPEENS 233

  Fly   654 STSATTTVKKQSVLYESLQQHPLAKYHQTQQQTTTTTTVDGQTSSRMELHKATLANAT------- 711
            :......||:::       :.|.|..........|.:..:..:.||..|:|..|.|::
Yeast   234 TEHVNDDVKEEA-------EAPSANMSLNVATDPTLSCKEPPSHSRNLLNKTPLRNSSGQYLAKS 291

  Fly   712 -------------------IDPVPVGSSKF------------VTLPDKPDKGSSVATLADIAESS 745
                               ||| |..||:.            |::..|..|||:    .||..:.
Yeast   292 PSSYRQGIIVNDSLEESDQIDP-PNNSSRNASELLTSVLHSPVSVNMKNPKGSN----TDIFNTG 351

  Fly   746 AAAIVD---SASGSGNVVRRYKPLSSSSFDEGKPMRRISYLRATNNETDFNAEAAAGGDAAATGA 807
            ..:.:|   |.....|:|.....|.....:..|..|.:..|.....|   .||..:..:.:..|.
Yeast   352 EISQMDPSLSRKVLNNIVEETNALQRPVVEVVKEDRSVPDLAGVQQE---QAEKYSYSNNSGKGR 413

  Fly   808 SGPASASAASS---------APGPTPSSAPAPAPAPAPLPISIPIPVAAVVEPQKTKSLVEEHPD 863
            ....|.|..|.         |.|...|              ::.:..|:.|..::::.|:.::
Yeast   414 KISRSLSRRSKDLMINLKSRATGKQDS--------------NVKLSPASKVTSRRSQDLMRDN-- 462

  Fly   864 PTYDVIGGTGGGHEFIETPN--------------GLEDVRLSAHGSRRASMSSD----------M 904
                      ..|..::|||              .|...|.:.:|:.|.:...:          .
Yeast   463 ----------DSHTGLDTPNSNSTSLDILVNNQKSLNYKRFTDNGTLRVTSGKETALEEQKNHSF 517

  Fly   905 RSSIHIDAELNGKYVPNELEAFETEIEIKSSCINGKRMSEYR-------SWR---QVKLEIKGDL 959
            :|...||..|.....|:.:..:.|.....|...:.:..|.|.       ||:   :.:||...:.
Yeast   518 KSPSPIDHLLQSPATPSNVSMYRTPPLDSSLTFDRRNGSSYSNQNYSIPSWQKTPKTQLENSDNF 582

  Fly   960 LR----IYSGRHAK-----------SEHNVIELDIRNFKFFDESMDK-KKYLIRMQSKPSPSGAH 1008
            ..    :|....::           :||.:.:|.| |.|..:...:: .|.:..|:|.......|
Yeast   583 EEQKETLYENSESRNDPSLDKEIVTAEHYLKQLKI-NLKELESQREELMKEITEMKSMKEALRRH 646

  Fly  1009 LASLGNELNLDEGHDKLLTSSGSSSANEPAANAAS------ALTASTSSSTCSSGPYTEILFKTK 1067
            :.|..:|.|      ||...|...|.|.|..|..|      ....:|:||...|
Yeast   647 IESYNSEKN------KLYLDSNELSNNPPMINEISLGESPPVKHVATASSVARS----------- 694

  Fly  1068 SSNEMKRLFGLLQWK-DSLNYDDNEHQPQGKQLAEPQKTVASASYLDDVQGGASAADSSPLSSHS 1131
               .:|..|    || .|......|...||.........|.||..|              ||:.|
Yeast   695 ---SVKPKF----WKFFSSAKPQTEQSIQGVSTNNTNSIVKSAPVL--------------LSAPS 738

  Fly  1132 GGIADASGSHHVSALPAAAAIVAATSDSISPVMK-ARKSSSHKHIP-DKDLGSPKSKNWKDLLFR 1194
            .|    |.|..:...|              ||:: ..:.|..:.:| :.|....:||:.::.|
Yeast   739 SG----SNSGRLEISP--------------PVLQNPNEFSDVRLVPIENDANMGQSKDGEEYL-- 783

  Fly  1195 RGGSGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVET--KGLGVV 1257
             .||...|         |:..|:           |  :..|..:|.::.||.:.:|:  :.:...
Yeast   784 -DGSNLYG---------SSLVAR-----------C--NYENNEIPMILSVCIDFIESDEENMRSE 825

  Fly  1258 GIYRIPGNKAAISELSELVNTKDFQFESCASDDRWE--------DVNVVSSLLKLFIRSLPDALM 1314
            ||||..|::..|.|:.:       ||.:.......|        |:|||:.:||.::|.||:.:.
Yeast   826 GIYRKSGSQLVIEEIEK-------QFSAWKVQQNTETPNILTEQDLNVVTGVLKRYLRKLPNPIF 883

  Fly  1315 PASYY---INFIEADK----------KFGLE---------RIVLLREIVESLPRHPYETMKHLIR 1357
            ....|   :..:::.|          |..||         ....|:.|:|.|||..|..::.|..
Yeast   884 TFQIYEPLMRLVKSKKMMENLPFVGGKLSLEAKNSDTYMSSKSALKNILEDLPREHYRVLRVLSE 948

  Fly  1358 HLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQY 1413
            |:.:|:.....|||...|||::|.|.:||  :.:.|..:.|||.:..||..:...|
Yeast   949 HIEKVTRYSHWNRMTLYNLALVFAPGLIR--DFSGEKDIIDMKERNYIVAFIFGNY 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	57/225 (25%)
RGA1	NP_014770.1	LIM1_Rga	13..67	CDD:188780
		LIM2_Rga	70..123	CDD:188781	3/11 (27%)
		Smc	<569..>673	CDD:224117	22/110 (20%)
		RhoGAP	803..1002	CDD:214618	54/207 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001164
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040