Protein Alignment RhoGAP19D and RGD1

DIOPT Version :10

• Sequence 1: NP_001285496.1
• Gene: RhoGAP19D / 33048
• FlyBaseID: FBgn0031118
• Length: 2206
• Species: Drosophila melanogaster
• Sequence 2: NP_009819.1
• Gene: RGD1 / 852563
• SGDID: S000000464
• Length: 666
• Species: Saccharomyces cerevisiae
• Alignment Length: 753
• Identity: 162/753 - (21%)
• Similarity: 267/753 - (35%)
• Gaps: 234/753 - (31%)

  Fly   807 ASGPASA--SAASSAPGPTPSSAPAPAPAPAPLPISIPIPVAAVVEPQKTKSLV----------- 858
            |..||||  ||.||..|.|...|...:.......::..:.:.|::...|...|.
Yeast     5 AKKPASATVSAKSSHDGGTDDLAHLFSTPEIKKVLNSDVAINALLSRLKQSLLTCEEFMKFIRKK 69

  Fly   859 ----EEHPDPT-------YDVIGGTGGG-----HEFIETPNGLEDVRLSAHGSRRASMSSDMRSS 907
                |||....       :::.|.|...     ||.:.....:..|:.| :.:....|.|::.|.
Yeast    70 YAFEEEHVQELSKQYKHFFNIQGSTNSSLKKMIHEVLGFDGKMAQVKQS-YITALQKMYSEISSL 133

  Fly   908 IHIDAELNGKYVPNELEAFETEIEIKSSCING--KRMSEYRS----W--------RQVKLEIKG- 957
            :....:|. |.|....:..|.::   |..|:.  |..|.|.|    |        .:.||.::|
Yeast   134 LLTMTKLR-KSVKENSKRLEKDV---SDAIHSAEKAQSRYNSLCQDWDKLRMTDPTKTKLTLRGS 194

  Fly   958 --------DLLRIYSGR---------HAKSEHN-----------------VIELD---------- 978
                    :|||.....         |:.|..|                 ::|:|
Yeast   195 KTTKEQEEELLRKIDNADLEYKQKVDHSNSLRNTFITKERPRIVQELKDLILEIDTAMTIQLQKY 259

  Fly   979 --------------------IRNFKFFDESMDKKKYLIRMQSKPSPSGAHLASLGNEL------- 1016
                                .::.|.|..|:..::.|....:|.:.:|.|...:...|
Yeast   260 TIWTENLVLNTGVTISPLDSTKSMKSFAGSVSNERDLYSFLNKYNQTGKHSLLINKNLIPVSYKK 324

  Fly  1017 --NLDEGHDKLLTSSGSSSANEPAANAASALTAST--------SSSTCSSGPYTEILFKTKSSNE 1071
              :::.|..   ..|....|.:|:.|:......||        |||..::.|...:...|.|.|.
Yeast   325 HPSMNHGQK---NKSPPKFAVDPSRNSIPKRMISTHNESPFLSSSSNTAAVPNANLNSATPSLNT 386

  Fly  1072 MKRLFGLLQWKDSLNYDDNEHQPQGKQLAEPQKTVASASYLDDVQGGASAADSSPLSSHSGGIAD 1136
            .|:|                           ..|:||:                 :||.|    :
Yeast   387 NKQL---------------------------PPTMASS-----------------ISSTS----N 403

  Fly  1137 ASGSHHVSALPAAAAIVAATSDSISPVMKARKSSSHK-HIPDKDLGSPKSKNWKDLLFRRGGSGS 1200
            |:|     |:..:::||  |||:.|.:.|.....::. .||::.:.|..|..
Yeast   404 AAG-----AMSPSSSIV--TSDTTSSITKTLDPGNNSPQIPEELINSLDSDR------------- 448

  Fly  1201 GGVSH---HDLASPSACAAKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVETKGLGVVGIYRI 1262
             .:||   ::...|.  ..|...:.||||.|. :......||.:|..|..:::..||...||||.
Yeast   449 -PISHIQTNNNMPPG--VQKNFKTFGVPLESL-IEFEQDMVPAIVRQCIYVIDKFGLDQEGIYRK 509

  Fly  1263 PGNKAAISELSELVNTKD-----FQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYINF 1322
            ..|...:|:|.|.:: ||     ....|....|  .|:.:|.||||.|..||||:::|.:
Yeast   510 SANVLDVSKLKEEID-KDPANISMILPSKPHSD--SDIYLVGSLLKTFFASLPDSVLPKA----- 566

  Fly  1323 IEADKKFGLE------RIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFG 1381
            :.::.|..|:      |...:..::.:||...|.|::.|:.||.||..:...|||..:.|.||:|
Yeast   567 LSSEIKVCLQIEDPTTRKNFMHGLIYNLPDAQYWTLRALVFHLKRVLAHEAQNRMNLRALCIIWG 631

  Fly  1382 PSII-RTPNDTLETAVKDMKHQCRIVELLVTQYDYFFE 1418
            |:|. ..|:|     ..|:..|...:|:|:...|..||
Yeast   632 PTIAPANPDD-----ANDVNFQIMAMEVLLEVSDQAFE 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_canonical	52..204	CDD:483948
		RhoGAP_ARHGAP21	1221..1417	CDD:239860	63/207 (30%)
RGD1	NP_009819.1	F-BAR_Rgd1	39..268	CDD:153336	37/233 (16%)
		RhoGAP_fRGD1	470..663	CDD:239863	63/206 (31%)