DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and RGA2

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_010667.1	Gene:	RGA2 / 851985	SGDID:	S000002787	Length:	1009	Species:	Saccharomyces cerevisiae

Alignment Length:	988	Identity:	195/988 - (19%)
Similarity:	348/988 - (35%)	Gaps:	254/988 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   582 HQQLQQTQHRQVMINNNAKYAKDLDYFETLQETGVTNKVFERKLVSHMSKGFDPFKPLSINTSAL 646
            |::|  .:.:|:::.|..|.:...|:...|.|..|..                |..|..||.
Yeast   123 HEKL--LRKKQLLLENQTKNSSKEDFPIKLPERSVKR----------------PLSPTRING--- 166

  Fly   647 ESSASTSSTSATTTVKKQSVLYESLQQHPLAKYHQTQQQTTTTTTVDGQTSSRMELHKATLANAT 711
            :|..||::|:.:..:...:   |..|..|.....|.:.:::.....|...|...|...:.....:
Yeast   167 KSDVSTNNTAISKNLVSSN---EDQQLTPQVLVSQERDESSLNDNNDNDNSKDREETSSHARTVS 228

  Fly   712 IDPVPVGSSKFVTLPDKPDKGSSVATLADIAESSAAAIVDSASGSGNVVRRYKPLSSSSFDEGKP 776
            ||.: :.|    ||  :.|..|       |.|.|.....|..:..|..| .|:.|        ||
Yeast   229 IDDI-LNS----TL--EHDSNS-------IEEQSLVDNEDYINKMGEDV-TYRLL--------KP 270

  Fly   777 MR-----------RISYLRATNN---------ETDFNAEAAAGGDAAATGASGPASASAASSAPG 821
            .|           ||....:..|         |||.:.......:..   .:.|.:::...::|.
Yeast   271 QRANRDSIVVKDPRIPNSNSNANRFFSIYDKEETDKDDTDNKENEII---VNTPRNSTDKITSPL 332

  Fly   822 PTPSSAPAPAPAPAPLPISIPIPVAAV--------VEPQKTKSLVEEHPDPTYDVIGGTGGGHEF 878
            .:|.:.........|..:::.:..|..        ::...:||:....|....|.:.
Yeast   333 NSPMAVQMNEEVEPPHGLALTLSEATKENNKSSQGIQTSTSKSMNHVSPITRTDTVE-------- 389

  Fly   879 IETPNGLEDVRLSAHGSRRASMSSDMRSSIHIDAELNGKYVPNELEAFETEIEIKSSCINGKRMS 943
            ::|......:|||.:||.....::|       :...:.|..|:..:.......:||
Yeast   390 MKTSTSSSTLRLSDNGSFSRPQTAD-------NLLPHKKVAPSPNKKLSRSFSLKS--------- 438

  Fly   944 EYRSWRQVKLEIKGDLLRIYSGRHAKSEHNVIELDIR----------NFKFFDESMDKKKYLIRM 998
                 :.....:|.....:...:|.....::.|.|..          |.:   :|..||..:.|.
Yeast   439 -----KNFVHNLKSKTSEMLDPKHPHHSTSIQESDTHSGWGVSSTHTNIR---KSKAKKNPVSRG 495

  Fly   999 QSKPSPSGAHLASLGNELNLDEGHDKLLTSSGSSSANEPAANAASALTASTSSSTCSSGPYTEIL 1063
            ||..:.... |...||....:..|.|..:|.||.|..:.:.:.|:....:.|.::.|||.:. .:
Yeast   496 QSDSTIYNT-LPQHGNFTVPEFNHKKAQSSLGSISKKQNSNDTATNRRINGSFTSSSSGHHI-AM 558

  Fly  1064 FKTKSSNEMKRLFGLLQWKDSLNYDDNEHQPQGKQLAEPQKTVASASYLDDVQGGASAADSSPLS 1128
            |:|.....     |.|..:.||:.:...|:....|.:.     ::.:.|:|......|.|.|..|
Yeast   559 FRTPPLES-----GPLFKRPSLSSESAHHRSSSLQTSR-----STNALLEDDSTKVDATDESATS 613

  Fly  1129 SHSG-------------GIADASGS-----HHVSALPAAAAIVAATSDSISPVMKARKSSSHKHI 1175
            ....             .:.:..|:     ..|..|..|...:....|:::.....:.:||.:.:
Yeast   614 LEKDFYFTELTLRKLKLDVRELEGTKKKLLQDVENLRLAKERLLNDVDNLTREKDKQSASSRESL 678

  Fly  1176 PDKD----------------------LGSPKSKNWKDLLF---------------RRGGSGSGG- 1202
            ..|:                      ..|||.:.||  :|               |...|.|||
Yeast   679 EQKENIATSITVKSPSSNSDRKGSISNASPKPRFWK--IFSSAKDHQVGDLESQQRSPNSSSGGT 741

  Fly  1203 --VSHHDLASPSACAA-KQIGSIG-VPLRSCPM-------------SKVNA-------YVPHLVE 1243
              ::..:::||..... .::.|.| |||...|.             |.:.|       .||.::.
Yeast   742 TNIAQKEISSPKLIRVHDELPSPGKVPLSPSPKRLDYTPDGSHLYGSSLQARCAYEKSTVPIIIR 806

  Fly  1244 VCTNIVETK--GLGVVGIYRIPGNKAAISELSELVNTKDF-QFESCASDDRW--------EDVNV 1297
            .|.:.:|..  ||.:.|:||..|::..:.|:.     .:| |..|..||...        :|::.
Yeast   807 CCIDRIEKDDIGLNMEGLYRKSGSQTLVEEIE-----NEFAQNNSLHSDTLSPKLNALLNQDIHA 866

  Fly  1298 VSSLLKLFIRSLPDALMPASYY-----------------IN---FIEADKKFGLERIVL--LREI 1340
            |:|:||.::|.|||.::..|.|                 :|   |:::.:|..:..:||  |.||
Yeast   867 VASVLKRYLRKLPDPVLSFSIYDALIDLVRNNQLIERLPLNNDKFLDSPQKVTIYEMVLKSLLEI 931

  Fly  1341 VESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRI 1405
            .:.||....|.:|.|..|:.:|....:.|.|...||:::|.||:|...:.  |..:.|||.:..|
Yeast   932 FKILPVEHQEVLKVLAAHIGKVRRCSERNLMNLHNLSLVFAPSLIHDFDG--EKDIVDMKERNYI 994

  Fly  1406 VELLVTQYDYFFE 1418
            ||.::..|...|:
Yeast   995 VEFILGNYRDIFK 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	66/249 (27%)
RGA2	NP_010667.1	LIM1_Rga	13..67	CDD:188780
		LIM2_Rga	70..123	CDD:188781	195/988 (20%)
		RhoGAP	815..1002	CDD:214618	53/193 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001164
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100