Protein Alignment RhoGAP19D and ARHGAP24

DIOPT Version :10

• Sequence 1: NP_001285496.1
• Gene: RhoGAP19D / 33048
• FlyBaseID: FBgn0031118
• Length: 2206
• Species: Drosophila melanogaster
• Sequence 2: NP_001020787.2
• Gene: ARHGAP24 / 83478
• HGNCID: 25361
• Length: 748
• Species: Homo sapiens
• Alignment Length: 754
• Identity: 170/754 - (22%)
• Similarity: 284/754 - (37%)
• Gaps: 177/754 - (23%)

  Fly  1083 DSLNY--DDNEHQPQGKQLAEPQKTVASASYLDDVQGGASAADSSPLSSHSGGIADASGSHHVSA 1145
            |.|.|  |::|.:|.|.......|  .|....::...|....:..|     ||..|...::|.|.
Human    46 DQLYYFKDEDETKPLGTIFLPGNK--VSEHPCNEENPGKFLFEVVP-----GGDRDRMTANHESY 103

  Fly  1146 LPAAAAIVAATSDSISPVMKARKSSSHKHIPDKDLGSPKSKNWKDLLFRRGGSGSGGVSHHDLAS 1210
            |     ::|:|.:.:...:|                |.:...|        |...||:....| .
Human   104 L-----LMASTQNDMEDWVK----------------SIRRVIW--------GPFGGGIFGQKL-E 138

  Fly  1211 PSACAAKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSEL 1275
            .:....|:.|              |...|.|||.|.:.:..:||...|::|:||....:.||.:.
Human   139 DTVRYEKRYG--------------NRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDA 189

  Fly  1276 VNTKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYINFIEADKKFGLERIVLLREI 1340
                 |......|.|...||:.|:|||||::|.||:.::|.:.|.:|:...|....|....::|:
Human   190 -----FDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAGVKEL 249

  Fly  1341 ---VESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQ 1402
               |:|||...|..:|::.|.|..|.....||:|..:|||.:|||:|:|...:...|.::.....
Human   250 AKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVEDPLTIMEGTVVV 314

  Fly  1403 CRIVELLVTQYDYFFEGGSLPDIAEVSGGTAAVSAAQPQ------QQTQEDQTSMLLHNLSKIER 1461
            .:::.::::::|..|     |..||:.        ::||      .:.|:..|...|.|  |...
Human   315 QQLMSVMISKHDCLF-----PKDAELQ--------SKPQDGVSNNNEIQKKATMGQLQN--KENN 364

  Fly  1462 ITERETTRTSRF----MPQLRRKTHGKRSAVN-SDTYS--------------------------G 1495
            .|:...:|...:    .||.....:|..:|:: |.|.|                          |
Human   365 NTKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPPLMVKKNPAFNKG 429

  Fly  1496 ESVLVSG--SSSNTTTTTTTTTHTTSSTSSSNTITTTISTTTIQQRRAQRKAVQSICDQALILLL 1558
            ..::.:|  ||||......|.|....|..:..:.:..:|.|.:.....|...|:.....:..|..
Human   430 SGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSVQNGTVRMGILNSDTLGN 494

  Fly  1559 PTPVSSVS-LP--FQSL-DYAKASASASASASSTASTSSS-----STLHSGGKASASSSSSSTTK 1614
            ||.|.::| ||  :.:| |..:...:......:..||..:     |.::...|.|..|::.||:.
Human   495 PTNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQQFSMMNLDDKQSIDSATWSTSS 559

  Fly  1615 FSSS---SSSACSTTAVAISSSISATSSKLLSANFK-----------------------KRSTGG 1653
            ...|   :|::|.      ||:.:.........||:                       .||.||
Human   560 CEISLPENSNSCR------SSTTTCPEQDFFGGNFEDPVLDGPPQDDLSHPRDYESKSDHRSVGG 618

  Fly  1654 FLGSRSSHQTRKASLDEKDSGQSSG--SLGHSLGVGINLAKEQQRSSVDISILLTDDDSSSRLSD 1716
                |||..|..:...|...|.||.  |..|||  ..:|.:|..:..::....:...:..:...:
Human   619 ----RSSRATSSSDNSETFVGNSSSNHSALHSL--VSSLKQEMTKQKIEYESRIKSLEQRNLTLE 677

  Fly  1717 TGSMSLTTITDTLDS----------KLRNLRSGSESNDE 1745
            |..|||   .|.||.          |:||.....|..::
Human   678 TEMMSL---HDELDQERKKFTMIEIKMRNAERAKEDAEK 713

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_canonical	52..204	CDD:483948
		RhoGAP_ARHGAP21	1221..1417	CDD:239860	56/198 (28%)
ARHGAP24	NP_001020787.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20
		PH_RhoGap24	18..131	CDD:241530	23/120 (19%)
		RhoGAP_ARHGAP22_24_25	131..329	CDD:239855	60/217 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..476		24/123 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	582..641		14/62 (23%)
		ERM_helical	652..>725	CDD:466641	12/65 (18%)