DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and Arhgap12

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	XP_006526377.1	Gene:	Arhgap12 / 75415	MGIID:	1922665	Length:	843	Species:	Mus musculus

Alignment Length:	876	Identity:	188/876 - (21%)
Similarity:	309/876 - (35%)	Gaps:	264/876 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 KATLANATIDPV------PVGSSKFVT---LPDKPDKGSSVATLADIAESSAAAIVDSASGSGNV 759
            |.....|.:.||      |..|.|.:.   |....:..:.:..|:...:.|:     |..|:| :
Mouse    68 KEVTRKALMPPVKQATGLPNNSMKTIQSMHLQRSTENVNKMPELSSFGKPSS-----SVQGTG-L 126

  Fly   760 VRRYKPLSSSSFDEGKPMRRISYLRATNNETDFNAEAAA-------------------------- 798
            :|.......|:::.|:.: .:| |..|:|...||:::.:
Mouse   127 IRDANQNFGSNYNSGQTL-NLS-LDLTHNNGKFNSDSHSPKVSSQNRTRLFGHFPGPEFLDIEKT 189

  Fly   799 ------GGDAAATGA--------SG-PASASAASSAPGPTPSSAPAP-APAPA------------ 835
                  ..|:|..|:        || ..|:|:.......||.:...| :|..|
Mouse   190 SFSQEQSCDSAGEGSERIQQDSESGDELSSSSTEQMRATTPPNQGRPDSPVYANLQELKISQSAL 254

  Fly   836 -PLPISIPIPVAAVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGLEDVRLSAHGSRRAS 899
             |||.|..|.|....|..|..|                  |..:.......|........:|..|
Mouse   255 PPLPGSPAIQVNGEWETHKDSS------------------GRCYYYNRTTQERTWKPPRWARDVS 301

  Fly   900 MSSDMRSSIHIDAELNGKYVPNELEAFETEIEIKSSCI---NGKRMSEYRSWRQVKLEIKGDLLR 961
            .|.|.:|             |.|.|...:|....|||.   :.:..|..|.|.:
Mouse   302 TSRDFQS-------------PGEQEPLSSEENYHSSCFSQSDSQCGSPPRGWSE----------- 342

  Fly   962 IYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPSGAHLASLGNELNLDEGHDKLL 1026
                          |||.|....:.....|:|:|..:.                   |:|.....
Mouse   343 --------------ELDERGHTLYTSDYTKEKWLKHVD-------------------DQGRQYYY 374

  Fly  1027 TSSGSSSANE-PAANAASALTASTSSSTCSSGPYTEILFKTKSSNEMKRLFGLLQW--------- 1081
            ::.||.|..| |..||             ||....||:........::....|.:|
Mouse   375 SADGSRSEWELPKYNA-------------SSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDS 426

  Fly  1082 --KDS-----LNYDDNEHQPQGKQLAEPQKTV--------------------------------- 1106
              |||     |...:||..|...:..:|..::
Mouse   427 NDKDSPTTTKLCLPENESPPTSSKHQDPAGSLKGQEKYGLLNVTKITENGKKVRKNWLSSWAVLQ 491

  Fly  1107 ASASYLDDVQGGASAADSSPLSSH------SGGI-----ADASGSHHVSAL---PAAAAIVAATS 1157
            .|:......||.:::...|..|..      .|.:     .|.|...:|..|   .....::.:.:
Mouse   492 GSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGAVIEMASKDKSSKKNVFELKTRQGTELLIQSDN 556

  Fly  1158 DS-ISPVMKARKSSSHKHIPDKDLG-------SP------KSKNWKDLLFRRGGSGSGGVSHHDL 1208
            |: |:...|...|:.:..:.:.|..       ||      |.|:.|:|...|...||...|....
Mouse   557 DAVINDWFKVLSSTINNQVAEADEAAEEETPDSPGVEKHDKEKDQKELKKLRSMKGSSMDSSEQK 621

  Fly  1209 AS-----------PSACAAKQIGSI-----GVPLRS-CPMSKVNAYVPHLVEVCTNIVETKGLGV 1256
            .:           |:..|.::.|.|     |..|.: |  .:.|..||..|::|...||..||.|
Mouse   622 KTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLC--QRENGTVPKFVKLCIEHVEEHGLDV 684

  Fly  1257 VGIYRIPGNKAAISELSELVNTKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYIN 1321
            .||||:.||.|.|.:|...|| .|.:.:  .:|.:|||::|::..||:|.|.||:.|...:::.:
Mouse   685 DGIYRVSGNLAVIQKLRFAVN-HDEKLD--LNDSKWEDIHVITGALKMFFRELPEPLFTFNHFND 746

  Fly  1322 FIEADKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIR 1386
            |:.|.|:...:|:..:::::..||:...:||:.|.|||.||..|.:.|||..:::||:|||::::
Mouse   747 FVNAIKQEPRQRVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVFGPTLLK 811

  Fly  1387 TPNDTLETAVKDMKHQCRIVELLVTQYDYFF 1417
            ...:|...||..: :|.:||||::.:....|
Mouse   812 PERETGNIAVHTV-YQNQIVELILLELSTVF 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	69/201 (34%)
Arhgap12	XP_006526377.1	SH3_ARHGAP12	13..72	CDD:213003	1/3 (33%)
		SH3-WW_linker	69..264	CDD:374675	37/202 (18%)
		PRP40	257..>409	CDD:227435	45/239 (19%)
		WW	266..296	CDD:238122	5/47 (11%)
		PH_ARHGAP9-like	462..573	CDD:270053	14/110 (13%)
		RhoGAP_ARHGAP27_15_12_9	651..836	CDD:239868	68/190 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010