DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and ARHGAP9

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_001306779.2	Gene:	ARHGAP9 / 64333	HGNCID:	14130	Length:	750	Species:	Homo sapiens

Alignment Length:	828	Identity:	187/828 - (22%)
Similarity:	294/828 - (35%)	Gaps:	232/828 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   726 PDKPDKGSSVATLADIAESSAAAIVDSASGSGNVVRRYKPLSSSSFDEGKPMRRISYLRATNNE- 789
            |..|.:||.:..|.....:.|         .|..|         |..||.   |...||.||::
Human    18 PRSPPRGSQLCALYAFTYTGA---------DGQQV---------SLAEGD---RFLLLRKTNSDW 61

  Fly   790 -TDFNAEAAAGGDAAATGASGPASASAASSA------------PGP-------------TPSSAP 828
             .....||.:........|:.....|..|.:            |||             .||.|.
Human    62 WLARRLEAPSTSRPIFVPAAYMIEESIPSQSPTTVIPGQLLWTPGPKLFHGSLEELSQALPSRAQ 126

  Fly   829 APAPAPAPLPISI----------PIPVAAVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPN 883
            |.:..|.|||..:          |..:....|....:||.:|  |...:....|.|....:..|.
Human   127 ASSEQPPPLPRKMCRSVSTDNLSPSLLKPFQEGPSGRSLSQE--DLPSEASASTAGPQPLMSEPP 189

  Fly   884 ---GLEDVRLSAHGSRRASMSSDMRSSIHIDAELNGKYVP--NELEAFETEIEIKSS-CINGKRM 942
               .|.|:       ||...|..           .|...|  ..|:|:|..::..|. |.....:
Human   190 VYCNLVDL-------RRCPRSPP-----------PGPACPLLQRLDAWEQHLDPNSGRCFYINSL 236

  Fly   943 SEYRSWRQVKLEIKGDLLRIYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPSGA 1007
            :..:||:              ..|.::||.|            ..||:..:.|.|......|...
Human   237 TGCKSWK--------------PPRRSRSETN------------PGSMEGTQTLKRNNDVLQPQAK 275

  Fly  1008 HLASLGNELNLDEGHDKLLTSSGSSSANEPAANA-ASALTASTSSSTCSSGPY----TEILFKTK 1067
            ...|       |.|..:.|...||.|.::..:.. ..||.|..........|:    :.:|..||
Human   276 GFRS-------DTGTPEPLDPQGSLSLSQRTSQLDPPALQAPRPLPQLLDDPHEVEKSGLLNMTK 333

  Fly  1068 SSNEMKRLFGLLQWKDSLNYDDNEHQPQGKQLA---EPQKTVASASYLDDVQGGASAADSSPLSS 1129
            .:...::|        ..|:..:.....|..|.   ||..|..|:        |...|.|.|.||
Human   334 IAQGGRKL--------RKNWGPSWVVLTGNSLVFYREPPPTAPSS--------GWGPAGSRPESS 382

  Fly  1130 -HSGGIADASGSH--------HVSALPAAAAIVAATSD--------SISPVMK--ARKSSSHKHI 1175
             ...|.|.|.|.|        |:..:|....::.:..:        ::..|::  .|...:.:..
Human   383 VDLRGAALAHGRHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWHRALRTVIERLVRWVEARREA 447

  Fly  1176 P-DKDLGSPKSKNWKDLLFRRGGSGSGGVS-HHDLASPSACAAKQI-----------GSIGV--- 1224
            | .:|.||...:|  .|..|..|||...:| ..|....|...:|.:           |..|.
Human   448 PTGRDQGSGDREN--PLELRLSGSGPAELSAGEDEEEESELVSKPLLRLSSRRSSIRGPEGTEQN 510

  Fly  1225 --------------PLRS-------------CPMSKV----NAYVPHLVEVCTNIVETKGLGVVG 1258
                          ||:|             |.:..:    ...||..:.:|...|:.:||.|.|
Human   511 RVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRLCIAAVDKRGLDVDG 575

  Fly  1259 IYRIPGNKAAISELSELVN-----TKDFQF---ESCASDDR-------WEDVNVVSSLLKLFIRS 1308
            |||:.||.|.:.:|..||:     |.|.::   |....:.|       |:|::||:..||||:|.
Human   576 IYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDSTEWDDIHVVTGALKLFLRE 640

  Fly  1309 LPDALMPASYYINFIEA----DKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVN 1369
            ||..|:|.....:|..|    :.:..|.:|   :|::.|:|:..::|:::|:.|||||..:.|.|
Human   641 LPQPLVPPLLLPHFRAALALSESEQCLSQI---QELIGSMPKPNHDTLRYLLEHLCRVIAHSDKN 702

  Fly  1370 RMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQYDYFF 1417
            ||.|.||.|:|||::.|...:|.:.|...: :..::|:|::|.:...|
Human   703 RMTPHNLGIVFGPTLFRPEQETSDPAAHAL-YPGQLVQLMLTNFTSLF 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	70/248 (28%)
ARHGAP9	NP_001306779.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..187		16/68 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..319		20/109 (18%)
		Lipid binding	342..345		0/2 (0%)
		Lipid binding	397..399		0/1 (0%)
		Lipid binding	432..669		59/238 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..488		13/43 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.040