DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and BCR

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_004318.3	Gene:	BCR / 613	HGNCID:	1014	Length:	1271	Species:	Homo sapiens

Alignment Length:	1319	Identity:	248/1319 - (18%)
Similarity:	429/1319 - (32%)	Gaps:	369/1319 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 AVAAPPHQHQQQQQQLISYPAVAAVTTSTPAGSPQSQSQ---SQSHSHPNTHHAPSLHGGSRSG- 312
            |..||....:.:.......||.|......||..|:::..   |...:.|.|...|   |.:.||
Human    80 AAQAPDGASEPRASASRPQPAPADGADPPPAEEPEARPDGEGSPGKARPGTARRP---GAAASGE 141

  Fly   313 --------SITSTASGGITV----------LSQPFY---------------------------PQ 332
                    |:.:..|....:          ..:|||                           .|
Human   142 RDDRGPPASVAALRSNFERIRKGHGQPGADAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLGSQ 206

  Fly   333 QQQQQQQQQQHRHPALTGGSSSIDFGDMAHGLRQHQQQQQHL-----YQQQQQHHQFMRANQPPN 392
            ..|.::::.||      |..||:  ||.:....:.:..:...     |:..:.:.:|::.|
Human   207 AMQMERKKSQH------GAGSSV--GDASRPPYRGRSSESSCGVDGDYEDAELNPRFLKDN---- 259

  Fly   393 LTVLSASSATNTPTPTAR-QPKSATSHNQALYAVGAGPSSAAGSGSGSLSGGSENSDLMIRL--- 453
              ::.|:..:..|.|... ||      .|::|..|    ...|.|.|.|......|:...||
Human   260 --LIDANGGSRPPWPPLEYQP------YQSIYVGG----MMEGEGKGPLLRSQSTSEQEKRLTWP 312

  Fly   454 ----------------------RESIKQKEEFLKSPVPASMS-SASSINGNQAQSSSPAQQQHLQ 495
                                  .|::...||...|...:.:| |.::....:.:|.||:
Human   313 RRSYSPRSFEDCGGGYTPDCSSNENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPS------ 371

  Fly   496 QHQQHFFPSHTPPGGVQVVVPPPRSRHQ-----------VMLKQQQQQQQQHQQHHVLGYDMYHS 549
            |:.|..|.|.:||      .|....||:           |.:::..|.....      |...:|
Human   372 QNSQQSFDSSSPP------TPQCHKRHRHCPVVVSEATIVGVRKTGQIWPND------GEGAFH- 423

  Fly   550 GGKLVQRSSTAPGSVCHQHQQQQQHHLYHQQQHQQLQQTQHRQVMINNNAKYAKDLDYFETLQET 614
             |.......|.||..|...:.::|..  ||.....:..:......:::..:.::|......|:.|
Human   424 -GDADGSFGTPPGYGCAADRAEEQRR--HQDGLPYIDDSPSSSPHLSSKGRGSRDALVSGALEST 485

  Fly   615 GVTNKVFERKL-----------------VSHMSKGFDPFKPLSINTSALESSASTSSTSATTTVK 662
            ..:....|:.|                 :||:.....|.|||        .:|:|:|....|:.:
Human   486 KASELDLEKGLEMRKWVLSGILASEETYLSHLEALLLPMKPL--------KAAATTSQPVLTSQQ 542

  Fly   663 KQSVLYESLQQHPLAK------YHQTQQQTTTTTTVD--GQTSSRMELHKATLANATIDPVPVGS 719
            .:::.::..:.:.:.|      :.:.||.:......|  .:.:|::.:::|.:.|
Human   543 IETIFFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDN---------- 597

  Fly   720 SKFVTLPDKPDKGSSVATLADIAESSAAAIVDSASGSGNVVRRYK-----PLSSSSFDE--GKPM 777
                           .....::||....|....|..|.|:..|..     |.:.:|.:.  .||:
Human   598 ---------------YGVAMEMAEKCCQANAQFAEISENLRARSNKDAKDPTTKNSLETLLYKPV 647

  Fly   778 RRISYLRATNNETDFNAEAAAGGDAAATGASGPASASAASSAPGPTPSSAPAPAPAPAPLPISIP 842
            .|::  |:|....|....                           ||:|.|           ..|
Human   648 DRVT--RSTLVLHDLLKH---------------------------TPASHP-----------DHP 672

  Fly   843 IPVAAVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGLEDVRLSAHGSRRASMSSDMRSS 907
            :...|:...|...|.:.|...|....:....|.|..:...:.:.::...|...|...:.:|:...
Human   673 LLQDALRISQNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLC 737

  Fly   908 IHIDAELNGK--------YVP---------NELEAFET----------EIEIKSSCINGKRMSEY 945
            ..:..:..||        |:|         :||||...          .::||.|.|......|.
Human   738 TKLKKQSGGKTQQYDCKWYIPLTDLSFQMVDELEAVPNIPLVPDEELDALKIKISQIKNDIQREK 802

  Fly   946 RSWR--------QVKLEIKGDLL---------RIYSGRHAKSEHNVIELDIRNFKFFDESMDKKK 993
            |:.:        :.||..:..||         |::| |:.||...:|..|....::.:...:::|
Human   803 RANKGSKATERLKKKLSEQESLLLLMSPSMAFRVHS-RNGKSYTFLISSDYERAEWRENIREQQK 866

  Fly   994 YLIRMQSKPSPSGAHLASLGNE-LNLDEGHDKLLTSSGSSSANEPAANAASALTASTSSSTCSSG 1057
            ...|..|..|   ..|..|.|. :.|...|...||.:.....:.......:.:..|.:....||.
Human   867 KCFRSFSLTS---VELQMLTNSCVKLQTVHSIPLTINKEDDESPGLYGFLNVIVHSATGFKQSSN 928

  Fly  1058 PYTEI------LFKTKSSNEMKRLFGLLQWKDSLNYDDNEHQPQGKQLAEPQKTVASASYLDDVQ 1116
            .|..:      .|..|:...:.|......|.:..     |.:.:|.|      |:....|
Human   929 LYCTLEVDSFGYFVNKAKTRVYRDTAEPNWNEEF-----EIELEGSQ------TLRILCY----- 977

  Fly  1117 GGASAADSSPLSSHSGGIAD-ASGSHHVSALPAAAAIVAATSDSISPVMKARKSSSHKHIPDKDL 1180
              ....:.:.:....|...| ..|...|...|.|                         :.|:|
Human   978 --EKCYNKTKIPKEDGESTDRLMGKGQVQLDPQA-------------------------LQDRD- 1014

  Fly  1181 GSPKSKNWKDLLFRRGG---SGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSKVNAYVPHLV 1242
                   |:..:....|   ..|...:..:.:.....:.||.|..||.: :....:..:.||::|
Human  1015 -------WQRTVIAMNGIEVKLSVKFNSREFSLKRMPSRKQTGVFGVKI-AVVTKRERSKVPYIV 1071

  Fly  1243 EVCTNIVETKGLGVVGIYRIPGNKAAISELSEL--VNTKDFQFESCASDDRWEDVNVVSSLLKLF 1305
            ..|...:|.:|:..|||||:.|....|..|...  ||.||........     |||.::..|||:
Human  1072 RQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEM-----DVNAIAGTLKLY 1131

  Fly  1306 IRSLPDALMPASYYINFIEA---DKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCD 1367
            .|.||:.|....:|.||.|.   ......|..:|  .::.|||.....|...|:.||.||:....
Human  1132 FRELPEPLFTDEFYPNFAEGIALSDPVAKESCML--NLLLSLPEANLLTFLFLLDHLKRVAEKEA 1194

  Fly  1368 VNRMEPKNLAIIFGPSIIR 1386
            ||:|...|||.:|||:::|
Human  1195 VNKMSLHNLATVFGPTLLR 1213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	55/171 (32%)
BCR	NP_004318.3	Kinase	1..426		71/392 (18%)
		Bcr-Abl_Oligo	3..75	CDD:286168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..173		18/95 (19%)
		BAT2_N	<81..174	CDD:284431	17/95 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..247		9/69 (13%)
		Binding to ABL SH2-domain	197..385		42/223 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..392		24/121 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..476		10/69 (14%)
		RhoGEF	502..690	CDD:279015	40/260 (15%)
		PH_BCR_vertebrate	684..877	CDD:270173	37/196 (19%)
		C2_ABR	913..1033	CDD:176068	24/170 (14%)
		RhoGAP_Bcr	1052..1252	CDD:239852	55/170 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940