Protein Alignment RhoGAP19D and Arhgap23

DIOPT Version :10

• Sequence 1: NP_001285496.1
• Gene: RhoGAP19D / 33048
• FlyBaseID: FBgn0031118
• Length: 2206
• Species: Drosophila melanogaster
• Sequence 2: XP_006533928.1
• Gene: Arhgap23 / 58996
• MGIID: 3697726
• Length: 1489
• Species: Mus musculus
• Alignment Length: 2225
• Identity: 439/2225 - (19%)
• Similarity: 669/2225 - (30%)
• Gaps: 939/2225 - (42%)

  Fly    52 PKLIVIRRRPNQGFGFTLRHFIAYPPEDDQASSSASGLVSGSATAATAASVSTNWPQEASSAAGS 116
            |:.:::|:....||||||||||.||||                     ::|.....:|.:...|.
Mouse    41 PRTLLLRKSLQDGFGFTLRHFIVYPPE---------------------SAVHCILKEEENGGRGG 84

  Fly   117 NSGSSSSVGVAGITGLEPTSPTSLPPYQVKAMETIFIKEVQANGPAHYANLQTGDRVLMVNNQPI 181
            ..|..              .|:  |.::::.|:|||:|.|:..||||.|.|:||||::.||.:.|
Mouse    85 RGGGG--------------GPS--PRHRLEPMDTIFVKNVKDGGPAHRAGLRTGDRLVKVNGESI 133

  Fly   182 AGIAYSTIVSMIKQTPAVLTLHVVPKECDVLQMHYTSIAH----TPESNRLTMSTHSPSLLANGS 242
            .|..||.::.:|:.:...|.|.::||:.|:||:.|:..|:    .|.|.........|.|..  .
Mouse   134 IGKTYSQVIGLIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPLCY--P 196

  Fly   243 HKTTFPAAAAVAAPPHQHQQQQQQLISYPAVAAVTTSTPAGSPQSQSQSQSHSHPNTHHAPSLHG 307
            .||..|...|                  ||.|.:.....:..|.......:.|.|
Mouse   197 RKTYAPPTRA------------------PAWATMVPEPISALPPDPRSPAAWSDP---------- 233

  Fly   308 GSRSGSIT----STASGGITVLSQP-----FYPQQQQQQQQQQQHRHPALTGGSSSIDFGDMAHG 363
            |||..|.|    ..:|.|   :|||     .:|....:.:..:....|......|.::.
Mouse   234 GSRVPSATRAHLDNSSLG---MSQPRPSPGAFPHLPSESRTPRAFPEPGSRVLPSRLEC------ 289

  Fly   364 LRQHQQQQQHLYQQQQQHHQFMRANQ------PPNLTVLSASSATNTPTPTARQPKSATSHNQAL 422
                ||...|....|...    ||.:      ||.   ..::|.......|...|...::...||
Mouse   290 ----QQALSHWLSNQIPR----RAGERRCPAMPPR---ARSASQDRLEDVTTHHPWPCSTSQDAL 343

  Fly   423 YAVG--------------AGPSSAAGSGSGSL--------SGGSENSDLMIRLRESIKQKEEFLK 465
            ..:|              ....||...|.|:|        ...|:...    .|.|.....:..:
Mouse   344 SQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRLERCGWASQRPS----ARTSACPSRDLTQ 404

  Fly   466 SPVPASMSSASSINGNQAQSSSPAQQQH---------------------LQQHQQHFFPSHTPPG 509
            :|.|:.:.....|.....:|.||:.|:.                     |.|....|.|..:.|
Mouse   405 APPPSGLQGLDDIGYIGYRSYSPSFQRRTGLLHALSFRDSPFGGLPTFSLAQSPASFPPEASEP- 468

  Fly   510 GVQVVVPPPRSRHQVMLKQQQQQQQQHQQHHVLGYDMYHSGGKLVQRSSTAPGSVCHQHQQQQQH 574
             .:||.|.|.:|      ..:...:.|:...||             |.....|
Mouse   469 -PRVVRPDPSTR------ALEPPAEDHRDEVVL-------------RQKPPTG------------ 501

  Fly   575 HLYHQQQHQQLQQTQHRQVMINNNAKYAKDLDYFETLQETGVTNKVFERKLVSHMSKGFDPFKPL 639
                    :::|.|..||:          :|.:.:...|.....:...||:.           ||
Mouse   502 --------RKVQLTPARQM----------NLGFGDESPEPEARGERLGRKVA-----------PL 537

  Fly   640 SINTSALESSASTSSTSATTTVKKQSVLYESLQQHPLAKYHQTQQQTTTTTTVDGQTSSRMELHK 704
                             |||.        :||...|.               :|..||..::|
Mouse   538 -----------------ATTE--------DSLASIPF---------------IDEPTSPSIDL-- 560

  Fly   705 ATLANATIDPVPVGSSKFVTLPDKPDKGSSVATLADIAESSAAAIVDSASGSGNVV--------- 760
                          .:|.|                     .|:|:|.||..|..|:
Mouse   561 --------------QAKHV---------------------PASAVVSSAMNSAPVLGTSPSSPTF 590

  Fly   761 -----RRYKPLSSSSFDEGKPMRRISYLRATNNETDFNAEAAAGGDAAATGASGPASASAASSAP 820
                 |.|....||.    |..||.|||.|...|...:.:     |...|...           .
Mouse   591 TFALSRHYSQDCSSI----KAGRRSSYLLAITTERSKSCD-----DGLNTFRD-----------E 635

  Fly   821 GPTPSSAPAPAPAPAPLPISIPIPVAAVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGL 885
            |......|:..|:                    .:.|.....|.:.|    :.|..|..:.|
Mouse   636 GRVLRRLPSRVPS--------------------LRVLRSFFTDGSLD----SWGTSEDADAP--- 673

  Fly   886 EDVRLSAHGSRRASMSSDMRSSIHIDAELNGKYVPNELEAFETEIEIKSSCINGKRM-SEYRSWR 949
                     |:|.| :||:..:...|....|       ..:..:|..|    .||:. ...|.|:
Mouse   674 ---------SKRHS-TSDLSDATFSDIRREG-------WLYYKQILTK----KGKKAGGGLRQWK 717

  Fly   950 QVKLEIKGDLLRIYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPSGAHLASLGN 1014
                       |:|:...|:|                .|:.|::      .:|.|:.|..|:.|
Mouse   718 -----------RVYAVLRARS----------------LSLSKER------REPGPAAAGAAAAG- 748

  Fly  1015 ELNLDEGHDKLLTSSGSSSANEPAANAASALTASTSSS------TCSSGPYTEILFKTKSSNEMK 1073
                          :|...| .|....:..:..|.|.:      ..::..:.|.||:.:..::|
Mouse   749 --------------AGEDEA-APVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDM- 797

  Fly  1074 RLFGLLQWKDSLNYDDN-EHQPQG--------KQLAEPQKTVASASYLDDVQGGASAADSSPLSS 1129
                 |.|..::..:.. |.:..|        |:|.:.:|...|:         ...|||||..|
Mouse   798 -----LGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSS---------GPKADSSPKGS 848

  Fly  1130 HS-GGIADASGSHHVSALPAAAAIVAATSDSISPVMKARKSSSHKHIPDKDLGSPKSKNWKDLLF 1193
            .. ||:.        |......|:....:....|..|           :..:.:||:. |
Mouse   849 RGLGGLK--------SEFLKQTAVRGLRTQEQPPGSK-----------EDSVAAPKTP-W----- 888

  Fly  1194 RRGGSGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVETKGLGVVG 1258
                 |...:..:..|:|.|        .|:.|..|..:..|..||.:|..|..|||.:||...|
Mouse   889 -----GINIIKKNKKAAPRA--------FGIRLEECQPATENQRVPLIVAACCRIVEARGLESTG 940

  Fly  1259 IYRIPGNKAAISELSELVN--TKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYIN 1321
            |||:|||.|.:|.|.|.:|  ..|...:    |:||:|:||:|||||.|.|.||:.|.....|.:
Mouse   941 IYRVPGNNAVVSSLQEQLNRGPSDINLQ----DERWQDLNVISSLLKAFFRKLPEPLFTDDKYND 1001

  Fly  1322 FIEADK-KFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSII 1385
            ||||:: :...||:..||:::..||.|.|||:|.|:.||..::.:.:.|:|||:|||::|||:::
Mouse  1002 FIEANRIEDSRERMKTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLV 1066

  Fly  1386 RTPNDTLETAVKDMKHQCRIVELLVTQYDYFFEGGSLPDIAEVSGGTAAVSAAQPQQQTQEDQTS 1450
            ||..|.:...|..|..:.:|||.|:...|:||                         ...||:
Mouse  1067 RTSEDNMTDMVTHMPDRYKIVETLIQHSDWFF-------------------------SDDEDK-- 1104

  Fly  1451 MLLHNLSKIERITERETTRTSRFMPQLRRKTHGKRSAVNSDTYSGESVLVSGSSSNTTTTTTTTT 1515
                                            |:|:.|:.
Mouse  1105 --------------------------------GERTPVDD------------------------- 1112

  Fly  1516 HTTSSTSSSNTITTTISTTTIQQRRAQRKAVQSICDQALILLLPTPVSSVSLPFQSLDYAKASAS 1580
                                        |..||:                    .:::|...:..
Mouse  1113 ----------------------------KEPQSV--------------------PNIEYLLPNIG 1129

  Fly  1581 ASASASSTASTSSSSTLHSGGKASASSSSSSTTKFSSSSSSACSTTAVAISSSISATSSKLLSAN 1645
            .:...|...|..|::.      :||.|..|...|     ....:...:|| |.|||.:.|.
Mouse  1130 RTVPPSDPGSADSTTC------SSAKSKGSWVPK-----KEPYAREMLAI-SFISAVNRKR---- 1178

  Fly  1646 FKKRSTGGFLGSRSSHQTRKASLDEKDSGQSSGSLGHSLGVGINLAKEQQRSSVDISILLTDDDS 1710
             |||.....|||.                                               |||||
Mouse  1179 -KKRREARGLGSS-----------------------------------------------TDDDS 1195

  Fly  1711 SSRLSDTGSMSLTTITDTLDSKLRNLRSGSESNDENGSPEFPKNRRHTLGQPLHMHSENIPYADE 1775
                               :.:......|::...|...|.                    |.|:|
Mouse  1196 -------------------EQEAHKAAVGTQEPPEGQLPG--------------------PAAEE 1221

  Fly  1776 SPERLFHQFCNPLETAPLSLHLSRSCTATNTIGGDEKPSKQSGGVAPLPPSLLKAAHKLQHSATV 1840
            :|.||     :| .|||                 ||:|:                      :.|.
Mouse  1222 APGRL-----SP-PTAP-----------------DERPA----------------------ADTR 1241

  Fly  1841 PIHQGSSTAPTSGAATPVGTPTGSGGAG--AIPSRSSSSSVTTLTK---------SIQPRFSNY- 1893
            .|..|.||..|...:...||.....|||  |...||..|.|.|.|:         |.:|.||::
Mouse  1242 SIVSGYSTLSTMDRSVCSGTGGRRAGAGDEADDERSELSHVETDTEGGAGPGGRLSRRPSFSSHH 1306

  Fly  1894 -----------LSYERGNAAAGGAERVVGSAGGAASDDDSEGSTTSDPKEKL-------LLGERP 1940
                       ||..|..|...||    |:|.......:..||.:|..:|.|       .||.||
Mouse  1307 LMPCDTLARRRLSRSRAEAEGPGA----GTARACPRGPEPPGSASSSSQESLRPPAAAPALGSRP 1367

  Fly  1941 SPSFFIERYNKKRRDHRLFRSASFNCRNYSTRHITAQTSGGVAAGVSGGVAGAVAVGVACCQALS 2005
            |.   :|....:.|.
Mouse  1368 SR---VEALRLRLRG-------------------------------------------------- 1379

  Fly  2006 TTGLTKDEKTDMNLTKKRQIQNKQNRSIKRRHTV-------------------GGPHDYSASNGG 2051
                |.|:...:.|.:....:.::.||..|||||                   |||.:    :.|
Mouse  1380 ----TADDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLNFNEWKELGGGGPQE----SVG 1436

  Fly  2052 CSNHSHGHDLAAINYNHHNRHHQQQLLKLGSATSGGGGSGAAAAETTTTTTTTTTVLRRLGTGQA 2116
            ...||...|                             ||.::.|:|                :|
Mouse  1437 VRPHSDNKD-----------------------------SGLSSLEST----------------KA 1456

  Fly  2117 GAEASVALPASSSGS 2131
            .|.::.:||:...|:
Mouse  1457 RASSAASLPSGDLGA 1471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_canonical	52..204	CDD:483948	47/151 (31%)
		RhoGAP_ARHGAP21	1221..1417	CDD:239860	81/198 (41%)
Arhgap23	XP_006533928.1	PDZ_ARHGAP21_23-like	41..157	CDD:467238	47/152 (31%)
		PHA03247	<176..578	CDD:223021	98/594 (16%)
		PH_ARHGAP21-like	691..811	CDD:269955	29/185 (16%)
		RhoGAP_ARHGAP21	903..1098	CDD:239860	82/206 (40%)