Protein Alignment RhoGAP19D and ARHGAP22

DIOPT Version :10

• Sequence 1: NP_001285496.1
• Gene: RhoGAP19D / 33048
• FlyBaseID: FBgn0031118
• Length: 2206
• Species: Drosophila melanogaster
• Sequence 2: XP_011538304.1
• Gene: ARHGAP22 / 58504
• HGNCID: 30320
• Length: 720
• Species: Homo sapiens
• Alignment Length: 787
• Identity: 169/787 - (21%)
• Similarity: 288/787 - (36%)
• Gaps: 214/787 - (27%)

  Fly  1057 GPYTEILFKTKSSNEMKRLFGLLQWK--------DSLNY--DDNEHQP------QGKQLAE-PQK 1104
            ||..:..:..|..:.||      .|:        |.|.|  |.:|.:|      ||.|:.| |..
Human    42 GPVLKAGWLKKQRSIMK------NWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPG 100

  Fly  1105 TVASASYLDDVQ-GGASAADSSPLSSHSGGIADASGSHHVSALPAAAAIVAAT----SDSISPVM 1164
            ......:|.::. |||...:..|                  |.|.|..::|::    .|.:..:.
Human   101 PEDPGKHLFEISPGGAGEREKVP------------------ANPEALLLMASSQRDMEDWVQAIR 147

  Fly  1165 K----------ARKSSSH--KHIPDKDLGSPKSKNWKDLLFRRGGSGSGGVSHHDLASPSACAAK 1217
            :          ||:|.:|  :.:|....|....:                ..||:         :
Human   148 RVIWAPLGGGTARRSHAHPLEPLPPGIFGQRLEE----------------TVHHE---------R 187

  Fly  1218 QIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSELVNTKDFQ 1282
            :.|....||              |||.|.:.:..:||...|::|:||....:.:|.:       .
Human   188 KYGPRLAPL--------------LVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQD-------S 231

  Fly  1283 FESCASD---DRWEDVNVVSSLLKLFIRSLPDALMPASYYINFIEA----DKKFGLERIVLLREI 1340
            |: |...   |...||:.|:|||||::|.||:.::|.:.|.:|:..    .|..| |..:.|.:.
Human   232 FD-CGEKPLFDSTTDVHTVASLLKLYLRELPEPVVPFARYEDFLSCAQLLTKDEG-EGTLELAKQ 294

  Fly  1341 VESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRI 1405
            |.:||:..|..::::.:.|..|....:||:|..:|||.:|||:|:|...:...|.::.......:
Human   295 VSNLPQANYNLLRYICKFLDEVQAYSNVNKMSVQNLATVFGPNILRPQVEDPVTIMEGTSLVQHL 359

  Fly  1406 VELLVTQYDYFF-----EGGSLPDIAEVSGGTAAVSAAQPQQQTQEDQ-----TSMLLHNLSKIE 1460
            :.:|:.::...|     ||.:.|     .||.........::.|::.|     ..:..|..|.::
Human   360 MTVLIRKHSQLFTAPVPEGPTSP-----RGGLQCAVGWGSEEVTRDSQGEPGGPGLPAHRTSSLD 419

  Fly  1461 RITERETTRTS--------------RFMPQLRRKTHGKRSAVNSDTYSGES----VLVSGSSSNT 1507
            .......:||:              :.:|..:......||...|....|.|    ::.||.:...
Human   420 GAAVAVLSRTAPTGPGSRCSPGKKVQTLPSWKSSFRQPRSLSGSPKGGGSSLEVPIISSGGNWLM 484

  Fly  1508 TTTTTTTTHTTSSTSSSNTITTTISTTTIQQRRAQRKAVQ--SICDQALILLLPTPVSSVSLPFQ 1570
            ...::...|..:|:.               .|.....:||  |..|.     :|.|.....:|
Human   485 NGLSSLRGHRRASSG---------------DRLKDSGSVQRLSTYDN-----VPAPGLVPGIP-- 527

  Fly  1571 SLDYAKASASASASASSTASTSSSSTLHSGGKASASSSSSSTTKFSSSSSSACST--TAVAISSS 1633
                     |.::.|.|.||:|.||.   ||      |.||.|...:|.|||.|:  |..|:..|
Human   528 ---------SVASMAWSGASSSESSV---GG------SLSSCTACRASDSSARSSLHTDWALEPS 574

  Fly  1634 ISATSS---KLLSANFKKRSTGGFLGSRSSHQTRKASLDEKDSGQSSGSLGHSLGVGINLAKEQQ 1695
            ...:||   |.|..:......|.  |:.:|..:...|...:.:.:|....|....:...|.:  |
Human   575 PLPSSSEDPKSLDLDHSMDEAGA--GASNSEPSEPDSPTREHARRSEALQGLVTELRAELCR--Q 635

  Fly  1696 RSSVDISILLTDDDSS------SRLSDTGSMSLTTITDTLDSKLRNLRSGSESNDENGSPEFPKN 1754
            |:..:.|:...::.|:      |||.:.......... .|:.||||.....|..:
Human   636 RTEYERSVKRIEEGSADLRKRMSRLEEELDQEKKKYI-MLEIKLRNSERAREDAE---------- 689

  Fly  1755 RRHTLGQ 1761
            ||:.|.|
Human   690 RRNQLLQ 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_canonical	52..204	CDD:483948
		RhoGAP_ARHGAP21	1221..1417	CDD:239860	53/202 (26%)
ARHGAP22	XP_011538304.1	PH_RhoGAP2	42..157	CDD:241529	27/138 (20%)
		RhoGAP_ARHGAP22_24_25	173..371	CDD:239855	57/245 (23%)
		Smc	<612..>702	CDD:440809	20/98 (20%)