DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP19D and ARHGAP23

DIOPT Version :9

Sequence 1:NP_001285496.1 Gene:RhoGAP19D / 33048 FlyBaseID:FBgn0031118 Length:2206 Species:Drosophila melanogaster
Sequence 2:NP_001186346.1 Gene:ARHGAP23 / 57636 HGNCID:29293 Length:1491 Species:Homo sapiens


Alignment Length:1977 Identity:415/1977 - (20%)
Similarity:638/1977 - (32%) Gaps:682/1977 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 PKLIVIRRRPNQGFGFTLRHFIAYPPEDDQASSSASGLVSGSATAATAASVSTNWPQEASSAAGS 116
            |:.:::.:.|..||||||||||.||||                     ::|..:..:|.:   |.
Human    41 PRTLLLYKSPQDGFGFTLRHFIVYPPE---------------------SAVHCSLKEEEN---GG 81

  Fly   117 NSGSSSSVGVAGITGLEPTSPTSLPPYQVKAMETIFIKEVQANGPAHYANLQTGDRVLMVNNQPI 181
            ..|..|                  |.|:::.|:|||:|.|:.:||||.|.|:||||::.||.:.:
Human    82 RGGGPS------------------PRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRLVKVNGESV 128

  Fly   182 AGIAYSTIVSMIKQTPAVLTLHVVPKECDVLQMHYTSIAH-------------TPE--------- 224
            .|..||.::::|:.:...|.|.::||:.|:||:.|:..|:             .||         
Human   129 IGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEARSIPEPPPICYPRK 193

  Fly   225 --------SNRLTMSTHSPSLLANGSHKTTFPAA---AAVAAPP--HQHQQQQQQLISYPAVA-- 274
                    |.|.||.....|.|.:....   |||   ..:..||  ..|.......:|.|..:  
Human   194 TYAPPARASTRATMVPEPTSALPSDPRS---PAAWSDPGLRVPPAARAHLDNSSLGMSQPRPSPG 255

  Fly   275 -----AVTTSTPAGSPQSQSQ--------SQSHSHPNTHHAPSLHGGSRSGSITSTASGGITVLS 326
                 :....||...|:..|:        .|:.||..::..|...|..|..::...|        
Human   256 AFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRAGERRCPAMAPRA-------- 312

  Fly   327 QPFYPQQQQQQQQQQQHRHPALTGGSSSIDFGDMAHGLRQHQQQQQHLYQQQQQHHQFMRANQP- 390
                  :...|.:.::...|.....|:|.|      .|.|..|:..|..:......:..|:.:. 
Human   313 ------RSASQDRLEEVAAPRPWPCSTSQD------ALSQLGQEGWHRARSDDYLSRATRSAEAL 365

  Fly   391 -PNLTV---------LSASSATNTPT-PTARQPKSATSHNQALYAVGAGPSSAAGSGSGSLSG-- 442
             |...|         .|..|:..||. ||...|               ||.:...||...|..  
Human   366 GPGALVSPRFERCGWASQRSSARTPACPTRDLP---------------GPQAPPPSGLQGLDDLG 415

  Fly   443 --GSENSDLMIRLRESIKQKEEFLKSPVPASMSSASSINGNQAQSSSPAQQQHLQQHQQHFFPSH 505
              |..:.....:.|..:.....|..||    .....:.|..|:.:|.|.:             :.
Human   416 YIGYRSYSPSFQRRTGLLHALSFRDSP----FGGLPTFNLAQSPASFPPE-------------AS 463

  Fly   506 TPPGGVQVVVPPPRSRHQVMLKQQQQQQQQHQQHHVLGYDMYHSGGKLVQRSSTAPGSVCHQHQQ 570
            .||   :||.|.|.:|   .|:...:.:                |.::|.|.....|        
Human   464 EPP---RVVRPEPSTR---ALEPPAEDR----------------GDEVVLRQKPPTG-------- 498

  Fly   571 QQQHHLYHQQQHQQLQQTQHRQVMINNNAKYAKDLDYFETLQETGVTNKVFERKLVSHMSKGFDP 635
                        :::|.|..||                                    |:.||..
Human   499 ------------RKVQLTPARQ------------------------------------MNLGFGD 515

  Fly   636 FKPLSINTSALESSASTSSTSATTTVKKQSVLYESLQQHPLAKYHQTQQQTTTTTTVDGQTSSRM 700
            ..|        |..||.........|...:...:||...|.               :|..||..:
Human   516 ESP--------EPEASGRGERLGRKVAPLATTEDSLASIPF---------------IDEPTSPSI 557

  Fly   701 ELHKATLANATIDPVPVGSSKFVTLPDKPDKGSSVATLADIAESSAAAIVDSASGSGNVV----- 760
            :|                .:|.|                     .|:|:|.||..|..|:     
Human   558 DL----------------QAKHV---------------------PASAVVSSAMNSAPVLGTSPS 585

  Fly   761 ---------RRYKPLSSSSFDEGKPMRRISYLRATNNETDFNAEAAAGGDAAATGASGPASASAA 816
                     |.|....||.    |..||.|||.|...|...:.:     |...|...   .....
Human   586 SPTFTFTLGRHYSQDCSSI----KAGRRSSYLLAITTERSKSCD-----DGLNTFRD---EGRVL 638

  Fly   817 SSAPGPTPSSAPAPAPAPAPLPISIPIPVAAVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIET 881
            ...|...||                            .:.|.....|.:.|    :.|..|..:.
Human   639 RRLPNRIPS----------------------------LRMLRSFFTDGSLD----SWGTSEDADA 671

  Fly   882 PNGLEDVRLSAHGSRRASMSSDMRSSIHIDAELNGKYVPNELEAFETEIEIKSSCINGKRM-SEY 945
            |            |:|.| :||:..:...|....|       ..:..:|..|    .||:. |..
Human   672 P------------SKRHS-TSDLSDATFSDIRREG-------WLYYKQILTK----KGKKAGSGL 712

  Fly   946 RSWRQVKLEIKGDLLRIYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPSGAHLA 1010
            |.|:           |:|:...|:|                .|:.|::      .:|.|:.|..|
Human   713 RQWK-----------RVYAALRARS----------------LSLSKER------REPGPAAAGAA 744

  Fly  1011 SLGNELNLDEGHDKLLTSSGSSSANEPAANAASALTASTSSS------TCSSGPYTEILFKTKSS 1069
            :.|               :|...| .|....:..:..|.|.:      ..::..:.|.||:.:..
Human   745 AAG---------------AGEDEA-APVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDR 793

  Fly  1070 NEMKRLFGLLQWKDSLNYDDN-EHQPQG--------KQLAEPQKTVASASYLDDVQGGASAADSS 1125
            ::|      |.|..::..:.. |.:..|        |:|.:.:|...|:         ...||||
Human   794 DDM------LGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSS---------GPKADSS 843

  Fly  1126 PLSSHS-GGIADASGSHHVSALPAAAAIVAATSDSISPVMKARKSSSHKHIP----DKDLGSPKS 1185
            |..|.. ||:..       ..|..:||....|.|                :|    |....:||:
Human   844 PKGSRGLGGLKS-------EFLKQSAARGLRTQD----------------LPAGSKDDSAAAPKT 885

  Fly  1186 KNWKDLLFRRGGSGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVE 1250
            . |          |...:..:..|:|.|        .||.|..|..:..|..||.:|..|..|||
Human   886 P-W----------GINIIKKNKKAAPRA--------FGVRLEECQPATENQRVPLIVAACCRIVE 931

  Fly  1251 TKGLGVVGIYRIPGNKAAISELSELVN--TKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDAL 1313
            .:||...||||:|||.|.:|.|.|.:|  ..|...:    |:||:|:||:|||||.|.|.||:.|
Human   932 ARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQ----DERWQDLNVISSLLKSFFRKLPEPL 992

  Fly  1314 MPASYYINFIEADK-KFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLA 1377
            .....|.:||||:: :...||:..||:::..||.|.|||:|.|:.||..::.:.:.|:|||:|||
Human   993 FTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLA 1057

  Fly  1378 IIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQYDYFFEGGSLPDIAEVSGGTAAVSAAQPQQ 1442
            ::|||:::||..|.:...|..|..:.:|||.|:...|:||..      .|..|....|...:|| 
Human  1058 LVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSD------EEDKGERTPVGDKEPQ- 1115

  Fly  1443 QTQEDQTSMLLHNLSKI-------------------------ERITERETTRTSRFMPQLRRKTH 1482
              .......||.|:.:.                         :....||....| |:..:.||..
Human  1116 --AVPNIEYLLPNIGRTVPPGDPGSDSTTCSSAKSKGSWAPKKEPYAREMLAIS-FISAVNRKRK 1177

  Fly  1483 GKRSAVNSDTYSGESVLVSGSSSNTTTTTTTTTHTTSSTSSSNTITTTISTTTIQQRRAQRKAVQ 1547
            .:|.|             .|..|:|...:....|...:.          :|....|.|.|.....
Human  1178 KRREA-------------RGLGSSTDDDSEQEAHKPGAG----------ATAPGTQERPQGPLPG 1219

  Fly  1548 SICDQALILLLPTPVSSVSLP-------------FQSLDYAKASASAS--ASASSTASTSSSSTL 1597
            ::..:|...|.| |.:....|             ..::|.:..|.::.  |.|...|....|...
Human  1220 AVAPEAPGRLSP-PAAPEERPAADTRSIVSGYSTLSTMDRSVCSGASGRRAGAGDEADDERSELS 1283

  Fly  1598 H----SGGKASASSSSSSTTK--FSSSSSSACSTTAVAISSSISATSSKLLSANFKKRSTGGFLG 1656
            |    :.|.|.|......|.:  |||.....|.|.|           .:.|:.........|..|
Human  1284 HVETDTEGAAGAGPGGRLTRRPSFSSHHLMPCDTLA-----------RRRLARGRPDGEGAGRGG 1337

  Fly  1657 SRSSHQTRKASLDEKDSGQSSGSLGHSLGVGINLAKEQQRSSVDISILLTDDDSSSRLSDTGSMS 1721
            .|:......||...::|.:...:.         ||....|.            .:.||...|   
Human  1338 PRAPEPPGSASSSSQESLRPPAAA---------LASRPSRM------------EALRLRLRG--- 1378

  Fly  1722 LTTITDTLDSKLRNLRSGSESNDENGSPEFPKNRRHTLGQPLHMHSENIPYADESPERLFHQFCN 1786
              |..|.|..:||.             |..|:.||.......|......|..|.:    |:::  
Human  1379 --TADDMLAVRLRR-------------PLSPETRRRRSSWRRHTVVVQSPLTDLN----FNEW-- 1422

  Fly  1787 PLETAPLSLHLSRSCTATNTIGGDEKPSKQSGGVAPLPPSLLKAAHKLQHSATVPIHQGSSTAPT 1851
                                        |:.||..|..|:..:|....:.|....:....:.||:
Human  1423 ----------------------------KELGGGGPPEPAGARAHSDNKDSGLSSLESTKARAPS 1459

  Fly  1852 SGAATPVGTPTGSGGAGAIPSRSSSSS 1878
            |.|:.| ..|..:|...:.|.|.|::|
Human  1460 SAASQP-PAPGDTGSLQSQPPRRSAAS 1485

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP19DNP_001285496.1 PDZ_signaling <151..205 CDD:238492 22/53 (42%)
RhoGAP_ARHGAP21 1221..1417 CDD:239860 82/198 (41%)
ARHGAP23NP_001186346.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 15..34
PDZ_signaling 41..151 CDD:238492 47/151 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..280 17/78 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 385..407 8/36 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 449..530 27/179 (15%)
PH 689..808 CDD:278594 30/184 (16%)
PH_ARHGAP21-like 690..810 CDD:269955 30/185 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 831..851 8/28 (29%)
RhoGAP_ARHGAP21 902..1097 CDD:239860 83/206 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1155 1/28 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1175..1367 42/235 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1420..1491 18/97 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142541
Domainoid 1 1.000 144 1.000 Domainoid score I4612
eggNOG 1 0.900 - - E1_KOG4407
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 268 1.000 Inparanoid score I3036
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41702
orthoMCL 1 0.900 - - OOG6_104725
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2255
SonicParanoid 1 1.000 - - X1550
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
109.720

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