DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP19D and ARHGAP21

DIOPT Version :9

Sequence 1:NP_001285496.1 Gene:RhoGAP19D / 33048 FlyBaseID:FBgn0031118 Length:2206 Species:Drosophila melanogaster
Sequence 2:XP_011517904.1 Gene:ARHGAP21 / 57584 HGNCID:23725 Length:1992 Species:Homo sapiens


Alignment Length:2429 Identity:513/2429 - (21%)
Similarity:831/2429 - (34%) Gaps:780/2429 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 PKLIVIRRRPNQGFGFTLRHFIAYPPEDDQASSSASGLVSGSATAATAASVSTNWPQEASSAAGS 116
            ||.:.: :|.:|||||||||||.||||                     :::..::..|.:   |:
Human    48 PKTVTL-KRTSQGFGFTLRHFIVYPPE---------------------SAIQFSYKDEEN---GN 87

  Fly   117 NSGSSSSVGVAGITGLEPTSPTSLPPYQVKAMETIFIKEVQANGPAHYANLQTGDRVLMVNNQPI 181
            ..|...:       .|||             |:|||:|:|:..|||..|.|.||||::.||.:.:
Human    88 RGGKQRN-------RLEP-------------MDTIFVKQVKEGGPAFEAGLCTGDRIIKVNGESV 132

  Fly   182 AGIAYSTIVSMIKQTPAVLTLHVVPKECDVLQ-MHYTSIAHTPESNRLTMSTHSPSLLANGSHKT 245
            .|..||.::::|:.:...|.|.|:||:.|:|| :.:|        ..:|...:|......|:...
Human   133 IGKTYSQVIALIQNSDTTLELSVMPKDEDILQVLQFT--------KDVTALAYSQDAYLKGNEAY 189

  Fly   246 TFPAAAAVAAPPHQHQQQQQQLISYP----AVAAVTTSTPAGSPQSQSQSQSHSHP--------- 297
            :..|......||          |.||    |.:|:........|.|....|..|.|         
Human   190 SGNARNIPEPPP----------ICYPWLPSAPSAMAQPVEISPPDSSLSKQQTSTPVLTQPGRAY 244

  Fly   298 --NTHHAPSLHGGSRSGSITSTASGGI-TVLSQPFYPQQQQQQQQQQQHRHPALTGGSSSIDFGD 359
              .....||....::|.:.....:..: ||:    .|.::.......::.|   ||.|...:  :
Human   245 RMEIQVPPSPTDVAKSNTAVCVCNESVRTVI----VPSEKVVDLLSNRNNH---TGPSHRTE--E 300

  Fly   360 MAHGLRQHQQQQQHLYQQQQQHHQFMRANQPP------NLTVLSASSATNTPTPTARQPKSATSH 418
            :.:|:           .:|.......|...||      :|....|.|.:..|:....:..:.:.|
Human   301 VRYGV-----------SEQTSLKTVSRTTSPPLSIPTTHLIHQPAGSRSLEPSGILLKSGNYSGH 354

  Fly   419 NQALYAVGAGPSSAAGSGSGSLSGGSENSDLMI---------------RLRESIKQKEEFLKSPV 468
            :.   .:.:..|.|..:.|.|::..|.||...|               ||....:..:|.|.|..
Human   355 SD---GISSSRSQAVEAPSVSVNHYSPNSHQHIDWKNYKTYKEYIDNRRLHIGCRTIQERLDSLR 416

  Fly   469 PASMSSA---------SSINGNQAQSSSPAQQQHLQQHQQ---------HFFPSHTPPGGVQVVV 515
            .||.|:.         :::.|.:..:|.....|.:|..|:         .....:.|....|..:
Human   417 AASQSTTDYNQVVPNRTTLQGRRRSTSHDRVPQSVQIRQRSVSQERLEDSVLMKYCPRSASQGAL 481

  Fly   516 PPPR---SRHQVMLKQQQQQQQQHQQHHVLGYDMYHSGGKLVQRSSTAPGS----------VCHQ 567
            ..|.   |.|:.......:.|.:..::...|..:..|.|   ::..|...|          :|.:
Human   482 TSPSVSFSNHRTRSWDYIEGQDETLENVNSGTPIPDSNG---EKKQTYKWSGFTEQDDRRGICER 543

  Fly   568 HQQQQQHHLYHQQQH---QQLQQTQHRQVM---INNNAKYAKDLDYFETLQETGVTNKVFERKLV 626
            .:||:.|..:.....   ..:..:.:|::.   :.:.:::.|.....:|||    :|:.|:....
Human   544 PRQQEIHKSFRGSNFTVAPSVVNSDNRRMSGRGVGSVSQFKKIPPDLKTLQ----SNRNFQTTCG 604

  Fly   627 SHMSKGFDPFKPLSINTSALESSASTSSTSATTTVKKQSVLYESL----QQHPLAKYHQT---QQ 684
            ..:.:|      :|.:.|.|....|.|..:.:|.|.|.|...:|.    .|.|:...||.   .|
Human   605 MSLPRG------ISQDRSPLVKVRSNSLKAPSTHVTKPSFSQKSFVSIKDQRPVNHLHQNSLLNQ 663

  Fly   685 QTTTTTTVDGQTSSRMELHKA-TLANATIDPVPVGSSKFVT----LPDKPDKGSSVATLADIAES 744
            ||...|  |.....::|..|: :|:.|:..|.|..|....|    ||............|:..:|
Human   664 QTWVRT--DSAPDQQVETGKSPSLSGASAKPAPQSSENAGTSDLELPVSQRNQDLSLQEAETEQS 726

  Fly   745 SAAAIVDSASGSGNVVRRYKPLSSSSFDEGKPMRRISYLRATNN-ETDFNAEAAAGGDA------ 802
                  |:......|:.|.||.|.....:  |:|..||:.|.|: ||..:.......||      
Human   727 ------DTLDNKEAVILREKPPSGRQTPQ--PLRHQSYILAVNDQETGSDTTCWLPNDARREVHI 783

  Fly   803 ------AATGASGPASASAA-----------------SSAPG------------------PTPSS 826
                  .|:..|.|..:.|:                 .|.|.                  ||..|
Human   784 KRMEERKASSTSPPGDSLASIPFIVKGIYYKECNNTEMSKPNVSLFSHAFSIQSSFRTDEPTSPS 848

  Fly   827 AP---APAPAPAPLPISI-PIPVAAVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPN---- 883
            ..   |..||.|.:..|. .:|..|.|.|..|.|........::|        ||.:..|:    
Human   849 IDHDIAHIPASAVISASTSQVPSIATVPPCLTTSAPLIRRQLSHD--------HESVGPPSLDAQ 905

  Fly   884 -------------GLEDVRLSAH---------------GSRRASMSS----DMRSSIHIDAELNG 916
                         ||:|.|..|.               .|:::|..|    |..|.:..||...|
Human   906 PNSKTERSKSYDEGLDDYREDAKLSFKHVSSLKGIKIADSQKSSEDSGSRKDSSSEVFSDAAKEG 970

  Fly   917 KYVPNELEAFETEIEIKSSCINGKRM-SEYRSWRQVKLEIKGDLLRIYSGRHAK---SEH----- 972
            ..   ......|:        .|||: ...|.|:|:.:.::|..|.:|..:..:   ||.     
Human   971 WL---HFRPLVTD--------KGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTTPSEEEQPIS 1024

  Fly   973 -NVIELDIRNFKFFDESMDKKKYLIRMQSKPSPSGAHLASLGNELNLDEGHDKLLTSSGSSSANE 1036
             |...:||      ..|..|:|.:.|:                                      
Human  1025 VNACLIDI------SYSETKRKNVFRL-------------------------------------- 1045

  Fly  1037 PAANAASALTASTSSSTCSSGPYTEILFKTKSSNEMKRLFGLLQWKDSLNYDD------------ 1089
                         ::|.|      |.||:.:..::|......:|...:||.:|            
Human  1046 -------------TTSDC------ECLFQAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLISRR 1091

  Fly  1090 ----NEHQPQGKQLAEPQKTVASASYLDDVQGGASAADSSPLSSHSGGIADASGSHHVSALPAAA 1150
                |....:.:||  |:....|.|....:.|    |.|.|                        
Human  1092 IKEYNNLMSKAEQL--PKTPRQSLSIRQTLLG----AKSEP------------------------ 1126

  Fly  1151 AIVAATSDSISPVMKARKSSSHKHIPDKDLGSPKSK-NWKDLLFRRGGSGSGGVSHHDL-ASPSA 1213
                .|....||    ::.|..|.:...|...||.| .|:        .|...:..... ..|:|
Human  1127 ----KTQSPHSP----KEESERKLLSKDDTSPPKDKGTWR--------KGIPSIMRKTFEKKPTA 1175

  Fly  1214 CAAKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSELVN- 1277
                 .|:.||.|..||.:..|.|:|.:|::|..:||.:||...||||:|||.||||.:.|.:| 
Human  1176 -----TGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNK 1235

  Fly  1278 -TKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYINFIEADKKFG-LERIVLLREI 1340
             ..|...:    ||:|.|:||:|||||.|.|.||:.|.....|.:||||::|.. |:|:..|:.:
Human  1236 GMADIDIQ----DDKWRDLNVISSLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRL 1296

  Fly  1341 VESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRI 1405
            :..||.|.|||:|.|..||..|:.|.:.|:|||:||||:|||:::||..|.:...|..|..|.:|
Human  1297 IHDLPEHHYETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKI 1361

  Fly  1406 VELLVTQYDYFF--EGGSLPDIAEVSGGTAAVSAAQPQQQTQEDQTSMLLHNLSKIERITERETT 1468
            ||.|:..:|:||  ||                 |.:|....||                   |:|
Human  1362 VETLIQHHDWFFTEEG-----------------AEEPLTTVQE-------------------EST 1390

  Fly  1469 RTSRFMPQL-RRKTHGKRSAVNSDTYSGESVLVSGSSSNTTTTTTTTTHTTSSTSSSNTITTTIS 1532
            ..|:.:|.: ...|:..|:.|:    .|:   ||.|:::.:|.:..:..:.....|...:.::|.
Human  1391 VDSQPVPNIDHLLTNIGRTGVS----PGD---VSDSATSDSTKSKGSWGSGKDQYSRELLVSSIF 1448

  Fly  1533 TTTIQQRRAQRKAVQSICDQALILLLPTPVSSVSLPFQSLDYAKASASASASASSTASTSSSSTL 1597
            ....::|:..::..|             |.||.. ...::.:.|.:.....:.:...|...|.||
Human  1449 AAASRKRKKPKEKAQ-------------PSSSED-ELDNVFFKKENVEQCHNDTKEESKKESETL 1499

  Fly  1598 HSG-----GKASASSSSSSTTKFSSSSSSACSTTAVAISSSISATSSK--LLSANFK--KRSTGG 1653
            ...     .|.:::....||||....|....||.:...|...::..:|  .||..|.  |.|...
Human  1500 GRKQKIIIAKENSTRKDPSTTKDEKISLGKESTPSEEPSPPHNSKHNKSPTLSCRFAILKESPRS 1564

  Fly  1654 FLGSRSSHQTRKASLDEKDSGQSSGSLGHSLGVGINLAKEQQRSS-----------VDISILLTD 1707
            .|..:|||      |:|  :|..||:| .|.....:||:...:.|           .::|.:.:|
Human  1565 LLAQKSSH------LEE--TGSDSGTL-LSTSSQASLARFSMKKSTSPETKHSEFLANVSTITSD 1620

  Fly  1708 DDSSSRLSDTGSMSLTTITDTLDSKLRNLRSGSESNDE------NGSP-------EFP------- 1752
            ..::|..:...|:..:.::..:.|...:  .|.|::||      .|.|       |||       
Human  1621 YSTTSSATYLTSLDSSRLSPEVQSVAES--KGDEADDERSELISEGRPVETDSESEFPVFPTALT 1683

  Fly  1753 --------------KNRRHTLGQPLHMHSENIPYADESPERLF--HQFCNPLETAPLSLHLSRSC 1801
                          .:||::.|..|.....::..:.:|..:||  |:.   :|...||...|...
Human  1684 SERLFRGKLQEVTKSSRRNSEGSELSCTEGSLTSSLDSRRQLFSSHKL---IECDTLSRKKSARF 1745

  Fly  1802 TATNTIGGDEKPSKQSGGVAPLPPSLLKAAHKLQHSATVPIHQGSSTAPTSGAATPVGTPTGSGG 1866
            .:.:...||.|..|::       |||.|....::...:.    ||...||.|             
Human  1746 KSDSGSLGDAKNEKEA-------PSLTKVFDVMKKGKST----GSLLTPTRG------------- 1786

  Fly  1867 AGAIPSRSSSSSVTTLTK-----SIQPRFSNYLSYERGNAAAGGAERVVGSAGGAASDDDSEGST 1926
                  .|.....|..||     .::||                          |.:||      
Human  1787 ------ESEKQEPTWKTKIADRLKLRPR--------------------------APADD------ 1813

  Fly  1927 TSDPKEKLLLGERPSPSFFIERYNKKRRDHRLFRSASFNCRNYSTRHITAQTSGGVAAGVSGGVA 1991
                                                .|...|:.   :.|:|:            
Human  1814 ------------------------------------MFGVGNHK---VNAETA------------ 1827

  Fly  1992 GAVAVGVACCQALSTTGLTKDEKTDMNLTKKRQIQNKQNRSIKRRHTVGGPHD---YSASNGGCS 2053
                                                 :.:||:||||:||..|   .|..|....
Human  1828 -------------------------------------KRKSIRRRHTLGGHRDATEISVLNFWKV 1855

  Fly  2054 NHSHGH---DLAAINYNHHNRHHQ---------QQLLKLGSATSGGGGSGAAAAETTTT---TTT 2103
            :...|.   :|:|:|........|         ::.|:..::....|..|....|..:|   .||
Human  1856 HEQSGERESELSAVNRLKPKCSAQDLSISDWLARERLRTSTSDLSRGEIGDPQTENPSTREIATT 1920

  Fly  2104 TTTVLRRLGTGQAGAEASVALPASSSGSSSNNN---NSPQSDGSNGNGGGVAGVASNAPPTGVGV 2165
            .|.:.....||           :|||..:|.|.   :.|.......||.....|:.||       
Human  1921 DTPLSLHCNTG-----------SSSSTLASTNRPLLSIPPQSPDQINGESFQNVSKNA------- 1967

  Fly  2166 GGNNSSGSSSNSSSTSTTPAGNGD 2189
                ||.:::.....|.||....:
Human  1968 ----SSAANAQPHKLSETPGSKAE 1987

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP19DNP_001285496.1 PDZ_signaling <151..205 CDD:238492 21/53 (40%)
RhoGAP_ARHGAP21 1221..1417 CDD:239860 87/198 (44%)
ARHGAP21XP_011517904.1 PDZ_signaling 48..155 CDD:238492 47/151 (31%)
PH_ARHGAP21-like 967..1076 CDD:269955 27/182 (15%)
PH 968..1073 CDD:278594 27/178 (15%)
RhoGAP_ARHGAP21 1178..1373 CDD:239860 87/198 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 144 1.000 Domainoid score I4612
eggNOG 1 0.900 - - E1_KOG4407
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 268 1.000 Inparanoid score I3036
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41702
orthoMCL 1 0.900 - - OOG6_104725
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2255
SonicParanoid 1 1.000 - - X1550
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.750

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