DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and arhgap33

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	XP_005158459.3	Gene:	arhgap33 / 569720	ZFINID:	ZDB-GENE-121105-12	Length:	1907	Species:	Danio rerio

Alignment Length:	1353	Identity:	270/1353 - (19%)
Similarity:	441/1353 - (32%)	Gaps:	394/1353 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1012 LGNELNLDEGH-DKLLTSSGSSSANEPAANAASALTASTSSSTCSSGPYTEILFKTKSSNEMKRL 1075
            :...|::.:|| .||:..:.....|....:.........|.::.:||...:::|..:.|.:.|..
Zfish    69 MSKRLSVVKGHFPKLVDCAHFHYENVDFGSIELQFANEQSDASWTSGSAKDLVFLVQVSCQGKTW 133

  Fly  1076 FGLLQWKDSLNYDDNEHQ-----PQGKQLAEPQ----------KTVASASYL-------DDVQGG 1118
            .....:::....|.:.||     ...:.||.|.          .|...:.||       |:....
Zfish   134 MVRRSYEEFRTLDAHLHQCIYDRRYSQLLALPALCEIGDRLEILTPLLSEYLNRLTMIVDNKLNC 198

  Fly  1119 ASAADSSPLSSHSGG-IADASGSHHVSALPAAAAI---VAATSDSIS------------PVMKAR 1167
            ........:.:|... :.....|.:|.|:.||..|   .|..||.||            |..:..
Zfish   199 GPVLTWMEIDNHGNRFLLKEEASLNVPAIAAAHVIKRYTAQASDEISIEVGDILSVIDMPPKEDT 263

  Fly  1168 KSSSHKH--------------IPDK---DLGSPKSKNWKDLLFRR-GGSGSGGVS--------HH 1206
            .....||              |.:|   .:.:|.||...||:..: |.:.:.|.|        |.
Zfish   264 TWWRGKHGFQVGFFPSECVELINEKMPQSVSAPVSKQEVDLMSSKPGATNTTGPSSPTSVSKKHG 328

  Fly  1207 DL---------ASPSACAAKQIGSIGVPLRSCPMSK--VNA--YVPHLVEVCTNIVETKGLGVVG 1258
            .|         :.|:....||.|.:...:..|.:.:  :|:  .||.::..|:..:|..|: |.|
Zfish   329 KLMGFLRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGLDVPQVLTSCSEFIEKHGV-VDG 392

  Fly  1259 IYRIPGNKAAISELSELVNTKDFQFES---CASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYI 1320
            |||..|..:.|.:|..     :|..|:   ...|...:|::.|.||.||:.|.||:.|:....|.
Zfish   393 IYRHSGVSSNIQKLRH-----EFDSENVPDLTKDVYMQDIHCVGSLCKLYFRELPNPLLTYQLYD 452

  Fly  1321 NFIEA-DKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSI 1384
            .|.|. .:....||:|.:.::::.||...|.|:::|||||..::.......|..|||||::.|::
Zfish   453 KFAECMGEMTEEERMVKVHDVIQQLPPPHYRTLEYLIRHLAHLATCSAETNMHIKNLAIVWAPNL 517

  Fly  1385 IRTPNDTLETA-------VKDMKHQCRIVELLVTQYDYFFEGGSLPDIAEVSGGTAAVSAAQPQQ 1442
            :|:..  :|.|       .|:::.|..:||.|
Zfish   518 LRSKE--IEAAGLTGADPFKEVRIQSVVVEFL--------------------------------- 547

  Fly  1443 QTQEDQTSMLLHNLSKIERITERETTRTSRFMPQLRRKTHGKRSAVNSDTYSGESVLVSGSSSNT 1507
                         ||.:|.:.....|...||....:..|..|
Zfish   548 -------------LSNVEVLFSDSFTSVGRFNAARQSLTRPK----------------------- 576

  Fly  1508 TTTTTTTTHTTSSTSSSNTITTTISTTTIQQRRAQRKAVQSICDQALILLLPTPVSSV------- 1565
                                 :.:||..:....||.:.      ||.:||..:|..::
Zfish   577 ---------------------SFVSTRLLSLEEAQART------QAPLLLQGSPHHAIGQFHTVL 614

  Fly  1566 SLPFQSLDYAKASASASASASSTASTSSSSTLHSGGKASA---SSSSSSTTKFSSSSSSA-CSTT 1626
            .||   :|..|.......||.     .|..|..:.||..|   ...:..|:.|..::|.| |...
Zfish   615 DLP---VDKRKRGMKVRKSAG-----GSWKTFFAIGKPGAVGRRKPARITSLFQPTTSHAGCRVD 671

  Fly  1627 AVAISSSISATSSKLLSANFKKRSTGGFLGSRSSHQTRKASLDEKDSGQSSGSL-----GHSLGV 1686
            :|.:.|:.|                             :.||..:.||...|.:     ..|...
Zfish   672 SVTLRSAKS-----------------------------EESLSSQHSGAGQGKIQRLRRPRSSSD 707

  Fly  1687 GINLAKEQQRSSVDISILLTDDDSSSRLSDTGSMSLTTITDTLDSKLRNLRSGSESNDENG---S 1748
            |::||     :|||..:|..:..|....|.:....|...|...|.:..|    .:..||.|   .
Zfish   708 GLSLA-----ASVDPQLLPQNSPSKIHPSRSYDSLLPEETRDADEEEEN----EDEEDEEGVYML 763

  Fly  1749 PEFPKNRRHTLGQPLHMHSENIPYADESPERLFHQFCNPLETAPLSLHLSRSCTATNTIGGDEKP 1813
            |:|.:.      .|....:|::  .|.||        ..||..|:.|         ...||  .|
Zfish   764 PDFSQE------PPSSWITEDV--IDFSP--------TFLEDGPIGL---------GGTGG--AP 801

  Fly  1814 SKQSGGVAPLPPSLLKAAHKLQHSAT-----------VPIHQGSSTAPTS---GAATP------- 1857
            |.:....|..||.....:|:..|:.:           ..::|..:.|..|   .||.|
Zfish   802 SGRESPPAAAPPPYRCLSHQGHHARSGSQRSITEDPDSVLNQSEAAARRSLILAAAAPPQQVFCQ 866

  Fly  1858 ------VGTPTGSGGAGAIPSRSSSSSVTTLTKSIQP---------RFSNYLSYERGNA------ 1901
                  ....|.||.:...||.:.:.:..|.....||         :..:.||.:...:
Zfish   867 HRPSNAPANTTQSGESNLSPSHAQTPAPATSAPPSQPPQERRSFTRKVVHALSPKAPKSPPLDIS 931

  Fly  1902 ---AAGGAERVVGSAGGAASDDDSEGSTTSDPKEKLLLGERPSPSFFIERYNKKRRDHRLFRSAS 1963
               |.....:|:...||.|.:..| |..:|.|         |.|...|.         .|.||..
Zfish   932 DPIAISVPAKVLEMIGGRAGELQS-GLPSSGP---------PQPPQMIS---------MLLRSCD 977

  Fly  1964 FNCRNYSTRHITAQTSGGVAAGVSG-GVAGAVAVGVACCQALSTTGLTKDEKTDMNLTKKRQIQN 2027
            |.......:.::::.  |..|.:.| .:.|...|.:...|..:...........:.||:......
Zfish   978 FQLTESCQQELSSKL--GPIAKIKGPSILGPTGVPLPSQQPPAPPPKNPARLMALALTESANKAL 1040

  Fly  2028 KQNRS--IKRRHTVGGP-------HDYSASNGGCSNHSHGHDLAAINYNHHNRHHQQQLLKLGSA 2083
            :|..|  .:.|.:...|       ...||..|           |.::.:.:..:...:.|.:..
Zfish  1041 RQGASPPYRPRQSAASPEKDIRFQRSLSADAG-----------ALLSSDPNQIYSTVRPLSVWK- 1093

  Fly  2084 TSGGGG------SGAA---AAETTTTTTTTTTVLRRLGTGQAGAEASVALPASSSGSSSNNNNSP 2139
            |.||.|      .|||   ||:.:..|...:...:.:||          |.::||.|.|...||.
Zfish  1094 TEGGDGDDEEDDEGAAAEKAADKSHGTEPRSPPGQDIGT----------LSSNSSVSDSGTTNSE 1148

  Fly  2140 QS--DGSNGNGGGVAGVASNAPPTGVGVGGNNSSGSSSNSSSTSTTPAGNGDQ 2190
            .|  ..|..|....:.:..|..||.......:|..|||:...:...|...|.|
Zfish  1149 LSAASSSEDNERTPSPIYKNEEPTSPPQPLISSPPSSSDLVPSQRKPPAYGRQ 1201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	58/210 (28%)
arhgap33	XP_005158459.3	PX_TCGAP	93..207	CDD:132832	17/113 (15%)
		SH3_ARHGAP32_33	229..282	CDD:212769	11/52 (21%)
		RhoGAP_CdGAP	356..550	CDD:239849	59/247 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030