DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and arhgap32b

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	XP_009293685.1	Gene:	arhgap32b / 569434	ZFINID:	ZDB-GENE-091204-147	Length:	1956	Species:	Danio rerio

Alignment Length:	1406	Identity:	292/1406 - (20%)
Similarity:	474/1406 - (33%)	Gaps:	464/1406 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   742 AESSAAAIVDS-------ASGSGNVVRRYKPLSSSSFDEGKPMRRISYLRATNNETDFNAEAAAG 799
            |.|.|||:|.|       |:||.::       |.|.|   .|:|.:...|.. .|.|...|.
Zfish     3 AGSGAAAVVGSAALGLLGATGSHDI-------SDSLF---SPLRGLRPGRHP-EEDDIVPEL--- 53

  Fly   800 GDAAATGASGPASASAASSAPGPTPS----------SAPAPAPAPAPLPISIPIPVAAVVEPQKT 854
                           |.|..|...|.          ||..|..:..||..|.....:..|:..|.
Zfish    54 ---------------ARSIHPRERPDWEETISAMARSAEIPELSSEPLMRSCSSTASMKVKNVKK 103

  Fly   855 KSLVEEH------------PDPTYDVIGGTGGGHEFIETPNGLED------VRLSAHGSRRASMS 901
            .|..:.|            .:..:..|..|....:...|.||||.      |::...|
Zfish   104 LSFTKGHFPKLAECAHFHYENVDFGTIQLTLADEQTEVTRNGLESKEPVYLVQIYCQG------- 161

  Fly   902 SDMRSSIHIDAELNGKYVPNELEAFETEIEIKSSCINGKRMSE------YRSWRQVKLEIKGDLL 960
               ||.|          |....|.|....:....||..:|.|:      :.|.|: :.|....:|
Zfish   162 ---RSWI----------VRRSYEDFRVLDKHLHLCIYDRRFSQLPELPRFDSLRE-RAEAVSQML 212

  Fly   961 RIYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPSGAHLASLGNELNLDEGHDKL 1025
            ..|..|.:....|                       ::...|:.:...:.:.||.|.:.|
Zfish   213 MAYLSRLSAIADN-----------------------KINCGPALTWMEVDNKGNHLLVHE----- 249

  Fly  1026 LTSSGSSSANEPAANAASALTASTSSSTCSSGPYTEILFKTKSSNEMKRLFGLLQW--KDSLNYD 1088
                 .||.|.||..||..:....:.:.      .|:.|      |:..:..::..  |:...:.
Zfish   250 -----ESSINVPAIAAAHVIKRYIAQAA------DELSF------EVGDIVSVIDMPPKEDTTWW 297

  Fly  1089 DNEHQPQGKQLA-EPQKTVASASYLDDVQGGASAADSSPLSSHSGGIADASGSHHVSALPAAAAI 1152
            ..:|   |.|:. .|.:.|...:  |.|....:.:...|.|..| |:..||.    |..|....:
Zfish   298 RGKH---GFQVGFFPSECVELIN--DKVPQSVTNSVPKPASPCS-GLRPASW----SLFPPYLEM 352

  Fly  1153 VAATSDSI---SPVMKARKSSSHKHIPDKDLGSPKSKNWKDLLFRRGGSGSGGVSHHDLASPSAC 1214
            .:...||.   .|:...|.||..|            |:.|.:.|.|....|         .|:..
Zfish   353 ESIKQDSALAPDPLNPYRLSSVSK------------KHGKLITFLRTFMKS---------RPTKQ 396

  Fly  1215 AAKQIGSIGVPLRSCPMSK--VNA--YVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSEL 1275
            ..||.|.:...:..|.:.:  :|:  .||.:::.||..:|..|: |.|:||:.|..:.|.:|...
Zfish   397 KLKQRGILRERVFGCDLGEHLLNSGHDVPQVLKSCTEFIEKHGV-VDGMYRLSGIASNIQKLRHE 460

  Fly  1276 VNTKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYINFIEA-----DKKFGLERIV 1335
            .:::  |......|...:|::.|.||.||:.|.||:.|:....|..|.||     |:    ||::
Zfish   461 FDSE--QIPDLTKDVYIQDIHCVGSLCKLYFRELPNPLLTYQLYEKFSEAVSAATDE----ERLI 519

  Fly  1336 LLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLET------ 1394
            .:.::::.||...|.|::.|:|||..::....|..|..|||||::.|:::|:..  :|:
Zfish   520 KIHDVIQQLPPPHYRTLEFLMRHLSHLATFSYVTNMHTKNLAIVWAPNLLRSKQ--IESACFSGT 582

  Fly  1395 -AVKDMKHQCRIVELLVTQYDYFFEGGSLPDIAE-VSGGTAAVSAAQP----------------- 1440
             |..:::.|..:||.::...|..|.    |.::. :..||...|.::|
Zfish   583 AAFMEVRIQSVVVEFILNHVDVLFS----PKLSSLIREGTGHNSLSRPKSLLVPSPSTKLLTLEE 643

  Fly  1441 -QQQTQEDQTSMLLHNLSKIE-------------RITERETTRTSRFMPQLRRKTH--------- 1482
             |.:||....|.:..:...||             .:.|..|.|  :..|...:|:.
Zfish   644 AQARTQAQINSPITADSKYIEVGEGPAALQGKFHTVIEFPTER--KRQPMKSKKSPVGSWRSFFN 706

  Fly  1483 -GKRSAVN--------SDTYSGESVLVSGSSSNTTT-------TTTTTTHTTSS----------T 1521
             ||.|:::        |:....:::.::|...:|.|       .:.|:.|....          .
Zfish   707 LGKSSSMSKRKLQRNPSEPNELKAMALAGGRGDTGTLRSAKSEESLTSLHNVEGESKVYRPRRPR 771

  Fly  1522 SSSNTITTTISTTTIQQRRAQRKAVQ-----------SICDQALIL---------LLPTPVSSVS 1566
            |||:.::.:.:...:..|:.......           .||..|||.         |.|..:...|
Zfish   772 SSSDALSASFNGDLLDTRQHCNSYDNLGHGDSDGDDGPICVPALISPPRSADDVDLSPPDIGMAS 836

  Fly  1567 LPFQ------SLDYAKAS---------------ASASASAS---------------STA------ 1589
            |.|.      ||..|:.|               ||.|.|.|               |||
Zfish   837 LDFDPMSFQCSLPLAETSIFSIDADTSSLKRSPASGSESVSPVRAKVTSRFLSPDHSTALKDKHK 901

  Fly  1590 -----------------------------STSSSSTLHSGGKASASSSSS------STTKFSSSS 1619
                                         |.|::|.:..|.:::....||      |.||.||.|
Zfish   902 LLLTSFSEKTPVQSVESTEMSAVVSPPSISESAASVIMKGPESTVLQPSSPPSPLDSPTKLSSLS 966

  Fly  1620 SSACSTTAVAISSSISATSSKLLS--ANFKKRSTGGFLGSR------SSHQTRKASLDEKDSG-- 1674
                .||.:.:|.:|   ..:|||  |.|:.:.......|:      |..|....:||.....
Zfish   967 ----RTTDLPLSEAI---QQELLSKAATFESKDISSIECSQPPQVTCSQEQPGAVALDSPKGNVP 1024

  Fly  1675 QSSGSL--------GHSLGVGINLAKEQQRSSVDISILLTDDDSSSRLSDTGSMSLTTITDTLD- 1730
            .||.||        ..:..:.:.||:..|::::     |:...||...:....:....:.:|||
Zfish  1025 VSSVSLVPPPPPPKNAARMLALALAESAQQATI-----LSQKQSSGPPTPVSPLRPQELLETLDW 1084

  Fly  1731 ---SKLRNLRSGSESNDENGSPEFPKNRRHTLGQPLHMHSENIPYADESPERLFHQFCNPLETAP 1792
               |.|.:..|..|:..|:.:...|      |..|          ....||::         |..
Zfish  1085 PLPSSLPSQPSEEETAVESSNKSVP------LSSP----------PSTPPEKM---------TRS 1124

  Fly  1793 LSLHL---------SRSCTATNTIGGDEKPSKQSGGVAPLPPSLLKAAHKLQHSATVPIHQGSST 1848
            :||||         |.||.:.:.| ..|.||:.:     :|..|.....:.|.|   |..|
Zfish  1125 VSLHLTTADSGKPSSISCNSQDVI-SPETPSQSA-----MPSCLTSHVSQTQKS---PEKQ---- 1176

  Fly  1849 APTSGAATPVGTPTGSGGAGAIPSRSSSSSVTTLTKSIQPR 1889
            .|..| .|||.|              :.::.||.|.:|..:
Zfish  1177 QPAVG-QTPVST--------------AKTTTTTTTSTISSK 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	57/211 (27%)
arhgap32b	XP_009293685.1	PX_domain	124..238	CDD:295365	27/157 (17%)
		SH3_ARHGAP32_33	260..313	CDD:212769	10/67 (15%)
		RhoGAP_CdGAP	407..601	CDD:239849	56/202 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940