DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and bcr

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	XP_002665983.2	Gene:	bcr / 568320	ZFINID:	ZDB-GENE-040724-43	Length:	1341	Species:	Danio rerio

Alignment Length:	1384	Identity:	264/1384 - (19%)
Similarity:	461/1384 - (33%)	Gaps:	420/1384 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   210 DVLQMHYTSIAHTP----ESNRLTMSTHSPSLLANGSHKTTFPAAAAVAAPPHQHQQQQQQLISY 270
            |.|::..:..||.|    |::.|:.||....:.....|.   |....:.:.|.|..:....|
Zfish   134 DGLELQSSFEAHQPGPVSEADGLSPSTQRGGVSPRRPHP---PPDKELPSDPSQKDKASMGL--- 192

  Fly   271 PAVAAV---------TTSTPAGSPQSQSQSQSHSHPNTHHAPSL---HGGSRSGSITSTASGGIT 323
             .|||:         ..|..|...:|..:...:::...||...|   :....|..|:|..:
Zfish   193 -GVAALRSNFERIKRANSHSASDGKSGQEKPFYTNVEFHHDRGLVKVNDREVSDKISSLGN---- 252

  Fly   324 VLSQPFYPQQQQQQQQQQQHRHPALTGGSSSIDFGDMAHGLRQHQQQQQHLYQQQQQHH------ 382
                    |..|.::::..|..|    |:.:...||:         :.:.:|:.:....
Zfish   253 --------QAMQMERKRSLHSLP----GNLATVAGDL---------RARPVYRGRSTESTCGYDA 296

  Fly   383 QFMRANQPPNLTVLSASSATNTPTPTARQPKSATSHNQALYAVGAGPSSAAGSGSGSL----SGG 443
            ::......|..:....:.|  .|.|...||.....:. ::|..|..|..   .|.|.:    .||
Zfish   297 EYEDGEPSPRYSAARPNGA--KPPPPPWQPSDFQPYT-SVYVGGMMPGE---GGDGRVPMREHGG 355

  Fly   444 SENSDLMIRLR------------------------ESIKQKEEFLKSPVPASMSSASSI---NGN 481
            |::..|....|                        |::...||...|...:.:|.:.:.   ...
Zfish   356 SDDHLLTWPRRSYSPGSYEDVGGGGGGYTPDCSSNENLTSSEEDFSSGQSSHVSPSPTTAYRRPI 420

  Fly   482 QAQSSSPAQQQHLQQHQQHFFPSHTPPGGVQVVVPPPRSRHQVMLKQQQQQQQQHQQHHVL---- 542
            :.:|.||:|.   .|:.||.|.|.:||                    ..|.|::|:|.||:
Zfish   421 REKSRSPSQN---SQNSQHSFDSSSPP--------------------TPQTQKRHRQQHVVVSEA 462

  Fly   543 --------GYDMYHSGGKLV-QRSS---------------TAP--GSVCHQHQQQQQHH------ 575
                    |....|.|..:. .|:|               |.|  |....:.::|::||
Zfish   463 TIVGVRKTGQIWPHDGESVASSRASHDNSYHGDLDGPFTGTPPTYGYDADRAEEQRRHHDILPYI 527

  Fly   576 --LYHQQQHQQLQQTQHRQVMINNNAKYAK--DLDYFETLQE-----TGVTNKVFERKLVSHMSK 631
              ......|...:....|..:.:.:.:.:|  :||..:.|:.     :|:.  ..|...:||:..
Zfish   528 DDSPSSSPHLSSKSRSSRDTLSSGSIESSKSAELDLEKGLEMRKRVLSGIL--ASEETYLSHLEA 590

  Fly   632 GFDPFKPLSINTSALESSASTSSTSATTTVKKQSVLYESLQQHPLAK--------------YHQT 682
            ...|.|||        .:|:|:|....|..:.:::.::..:.:.:.|              :||.
Zfish   591 LLLPMKPL--------KAAATTSQPVLTVQQIETIFFKVPELYEIHKEFYDSLLPRVQQWSHHQR 647

  Fly   683 -----QQQTTTTTTVDGQTSSRMELHKA-----TLANATIDPVPVGSSKFVTLPDKPDKGSSVAT 737
                 |:|           :|::.|::|     .||..|.:.....:::|
Zfish   648 VGDLFQKQ-----------ASQLGLYRAFVDNYELAVETAEKCCQANTQF--------------- 686

  Fly   738 LADIAESSAAAIVDSASGSGNVVRRYKPLSSSSFDEGKPMRRISYLRATNNETDFNAEAAAGGDA 802
             |:|:||..   |.|.....::..:|. |.:..:   ||:.|::  |:|....|....
Zfish   687 -AEISESLK---VRSTKECKDLTAKYS-LETLLY---KPVDRVT--RSTLVLHDLLKH------- 734

  Fly   803 AATGASGPASASAASSAPGPTPSSAPAPAPAPAPLPISIPIPVAAVVEPQKTKSLVEEHPDPTYD 867
                                ||||.|           ..|:...|:...|...|.:.|...|...
Zfish   735 --------------------TPSSHP-----------DYPLLQDALRISQNFLSSINEESTPRRQ 768

  Fly   868 VIGGTGGGHEFIETPNGLEDVRLSAHGSRRASMSSDMRSSIHIDAELNGK--------YVPNELE 924
            .:....|.:..:.....:.::...|...|...:.:|:.....:...:.||        |:|....
Zfish   769 SMTVKKGENRQLLKDGFMVELVEGARKLRHVFLFTDLLLCAKLKKLIGGKSQQYDSKWYIPLSDL 833

  Fly   925 AFET------------------EIEIKSSCINGKRMSEYRSWRQVKL--EIKGDL---------- 959
            .|:|                  .|:||.|.:..:...|.|:.:..|:  .:|..|
Zfish   834 TFQTAEESEPLPIPQAPDEELDAIKIKISSLRSEIQRERRANKGSKVMERLKKKLSEQESLFLLN 898

  Fly   960 -----LRIYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPSGAHLASLGNELNLD 1019
                 ||::: |:.||...:|..|....::        |.:||.|.|......:|:|:  ||
Zfish   899 SPNMPLRVHN-RNGKSYMFLISSDYERAEW--------KEVIREQQKKCFKTFNLSSM--EL--- 949

  Fly  1020 EGHDKLLTSSGSSSANEPAANAASALTASTSSSTCSSGPYTEILFKTKSSNEMKRLFGLLQ---- 1080
                ::||:|                  .....|....|.|    ..|..:|...|:|.|.
Zfish   950 ----QMLTNS------------------CVKLQTVHQLPLT----VNKEEDESTGLYGFLNVIVH 988

  Fly  1081 ----WKDSLN-YDDNEHQPQG----KQLAEPQKTVASASYLDDVQGGASAADSSPLSSHSGGIAD 1136
                .|.||| |...|....|    |......:......:.::.:                  .:
Zfish   989 SASGLKQSLNLYCTLEVDSFGIFVNKAKTRVYRYTTEPKWNEEFE------------------IE 1035

  Fly  1137 ASGSHHVSALPAAAAIVAATSDSISPVMKARKSSSHKHIPDKDLGSP---------KSKNWKDLL 1192
            ..|||.:..|        ....|.:   ||:.:.......|:.:|..         :.|:|:..:
Zfish  1036 LEGSHTLRLL--------CYEKSYN---KAKVNKEDGESTDRIMGKGQMPLDPQMLQGKDWQRTV 1089

  Fly  1193 FRRGG---SGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVETKGL 1254
            ....|   ..|...:..:.:.....:.|.:|..||.: |....:..:.||::|..|...:|.:|:
Zfish  1090 IPMNGIEVKISMKFTSREFSLKRMPSRKPMGVFGVNI-STVTKRERSKVPYIVRQCLEEIERRGM 1153

  Fly  1255 GVVGIYRIPGNKAAISELSELVNTKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYY 1319
            ..|||||:.|....|..|....:|.:.......|:   .|||.::..|||:.|.||:.|.....|
Zfish  1154 EEVGIYRVSGVATDIQALKTAFDTNNKDVSVMMSE---MDVNAIAGTLKLYFRELPEPLFTDELY 1215

  Fly  1320 INF---IEADKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFG 1381
            .||   |........|..:|  .::.|||.....|...|:.||.|::....||:|...|||.:||
Zfish  1216 PNFAGGIALSDSVAKESCML--NLLLSLPEPNLVTFLFLLDHLKRIAEKECVNKMSLHNLATVFG 1278

  Fly  1382 PSIIRTPNDTLETAVKDMK 1400
            |:::|       .|.||.|
Zfish  1279 PTLLR-------PAEKDSK 1290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	57/183 (31%)
bcr	XP_002665983.2	Bcr-Abl_Oligo	3..75	CDD:286168
		RhoGEF	573..761	CDD:279015	47/271 (17%)
		PH-like	755..947	CDD:302622	35/200 (18%)
		C2_ABR	983..1103	CDD:176068	22/148 (15%)
		RhoGAP_Bcr	1122..1322	CDD:239852	57/182 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940