DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP19D and arhgap27

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	XP_005156083.1	Gene:	arhgap27 / 564211	ZFINID:	ZDB-GENE-030131-3922	Length:	999	Species:	Danio rerio

Alignment Length:	940	Identity:	210/940 - (22%)
Similarity:	337/940 - (35%)	Gaps:	238/940 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   631 KGFDPFKPLSINTSALESSASTSSTSATTTVKKQSVLYESLQQHPLAKYHQTQQQTTTTTTVDGQ 695
            ||.|| .|  |.|.|......:|:||:.|..:...::...    |:...:.||...|.|.:||..
Zfish   143 KGLDP-DP--IKTEAEAGPPVSSNTSSPTNGETAFIILPP----PVYTVNTTQSTETDTRSVDDP 200

  Fly   696 TSSRMELHKATLANATIDP--------------VPVGSSKFV----------------------T 724
            ..|   :.:..:.::|||.              ..:|..|.|                      |
Zfish   201 KDS---VGRPRVDSSTIDEDIQMLNRAGWSEVLDVMGKEKNVYESLDTVREPESPKDEADMTVNT 262

  Fly   725 LPDKPDKGSSVATLADIAESSAAAIVDSASGSGNVVRRYKPLSSSSFDEGKPMRRISYLRA---- 785
            .|..||        |.:.|...|..|:........:....|::|...|..:|........|
Zfish   263 TPVTPD--------APMVEDDTAVYVNIPRKRQTTINNSSPIASLLQDFPEPPENFLLDSAGWQV 319

  Fly   786 -TNNET--DFNAEAAAGGDAAATGASGPASASAASSAPGPTPSSAP-APAPAP-APLPISIPIPV 845
             |::::  :|..:.:.|........|..:..|...:..|.:|.|.| :||.:| ||
Zfish   320 HTDDQSGQEFYYQPSTGRSTWENPLSSRSMESPVGTEGGRSPPSFPQSPACSPVAP--------- 375

  Fly   846 AAVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGL------EDVRLSAHGSRRASMSSDM 904
                .|::..|..|:       |:..:.|.|.|..|.:|.      |||    ....|.....|.
Zfish   376 ----APRRWSSDWEK-------VLDESTGRHYFFNTVSGQSSWDPPEDV----DSPGRLMFLDDC 425

  Fly   905 RSSIHIDAELNGKYVPNELEAFETEIEIKSSCINGKRMSEYR---------SWRQVKLEIKGDLL 960
            ...:   .|.:....|...||....|..:.|.|:.|::|..|         .|   .|:|..:..
Zfish   426 PPPL---PEEDYPASPELEEASPVSIPAEYSLIHVKKVSIPRVSLDRSSPAGW---SLDIDSEGT 484

  Fly   961 RIYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKP----------------------- 1002
            ..::..:.: |..:..||         ...:..|.:|..||.
Zfish   485 WTFTSEYTQ-EQWIKSLD---------DQGRTYYYLRDGSKSQWNLPEINPGQGGVAAQWLALLP 539

  Fly  1003 -------SPSGAHLAS-----LGNELNLDEGHDKLLTSSGSSSANEPAANAASALTASTSSSTCS 1055
                   |..|.:.||     :||..:   |....:.|:...||..|.....|:...:||.|..|
Zfish   540 YSKNVAGSSPGWYSASPGQYGVGNGAS---GEQDTVGSNWRHSAGYPDDKNHSSYIQNTSDSEAS 601

  Fly  1056 SGPYTE----------ILFKTKSSNEMKRLFGLLQWKDSLNYDDNEHQPQGKQLA---EPQKTVA 1107
            |.|.|.          ||.|||.|...|::        ..|:..:.....|.:|.   :|:.|.|
Zfish   602 SSPDTPHNVSNLEKAGILNKTKVSENGKKV--------RKNWGHSWTVLHGGKLTFHKDPKSTPA 658

  Fly  1108 SAS---------YLDDVQGGASAADSSPLSSHSGGIADASGSHHVSAL---PAAAAIVAATSDSI 1160
            .||         :..|::|  :..:.:|        .|.|...:|..|   ..|..::...:|||
Zfish   659 GASSKTNQILPEFTVDLKG--ATINRAP--------KDKSSKKNVLELKTRTGAEYLIQYDTDSI 713

  Fly  1161 ---------SPVMKARKSSSHKHIPDKDLGS---------PKSKNWKDLLFRRGGSGSGGVSHHD 1207
                     ..:.:......|....|:.:..         |..|.......|:..:.|...:...
Zfish   714 IQDWHKVILDTIHQLNGDQHHSEEEDEVIDKSPTLDREERPFEKRTMSTATRQPSTSSTSEAEQK 778

  Fly  1208 ----------LASPSACAAKQIGSIGVPLRSCPM----SKVNAYVPHLVEVCTNIVETKGLGVVG 1258
                      |..|:..:.|..|.|...:..|.:    |:....||..||.|...||.:||.:.|
Zfish   779 KVRTKLKKFLLKRPTLQSVKDKGYIRENVFGCHLHNLCSQEKTRVPSFVEKCIRAVEKRGLEIDG 843

  Fly  1259 IYRIPGNKAAISELSELVNTKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYINFI 1323
            :||:.||.|.|.:|....:.:|...|    :..| |::|::..||||.|.|.:.|.|.:.:..||
Zfish   844 LYRVSGNLAVIQKLRFKADHEDLDLE----EGNW-DIHVITGALKLFFRELQEPLFPYNLFNEFI 903

  Fly  1324 EADKKFG-LERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRT 1387
            .|.|... ..:|..:|.:|.|||...::||:.|..||.||..:.:.|||..:|:||:|||::::.
Zfish   904 CAIKTPDYYSKISHMRNLVRSLPPPNHDTMEALFSHLRRVIQHGNENRMTVQNVAIVFGPTLLKP 968

  Fly  1388 PNDTLETAVKDMKHQCRIVELLVTQYDYFF 1417
            ..:|...|.. |..|.:|||.|:::::..|
Zfish   969 EEETASIATY-MVFQNQIVEFLLSEFESIF 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	67/200 (34%)
arhgap27	XP_005156083.1	SH3	22..77	CDD:302595
		WW	315..343	CDD:278809	4/27 (15%)
		WW	382..410	CDD:278809	8/34 (24%)
		PH	613..726	CDD:278594	26/130 (20%)
		PH_ARHGAP9-like	614..725	CDD:270053	26/128 (20%)
		RhoGAP_ARHGAP27_15_12_9	808..992	CDD:239868	66/189 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23176
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010