DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP19D and arhgap12a

DIOPT Version :9

Sequence 1:NP_001285496.1 Gene:RhoGAP19D / 33048 FlyBaseID:FBgn0031118 Length:2206 Species:Drosophila melanogaster
Sequence 2:XP_021336423.1 Gene:arhgap12a / 563267 ZFINID:ZDB-GENE-050809-38 Length:853 Species:Danio rerio


Alignment Length:815 Identity:187/815 - (22%)
Similarity:315/815 - (38%) Gaps:181/815 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   714 PVPVGSSKFVTLPDKPDKGSSVATLADIAESSAAAIVDS-----ASGSGNVV--RRYKPLSSSSF 771
            |.|..||. ..||.:.|:||.|:....:..:.......|     |...|:.:  .|.|...|...
Zfish   107 PCPSPSST-ALLPPRDDRGSPVSPTRHLPPAQMNTFPGSLPCFRAESPGSKLDGERDKDKDSERK 170

  Fly   772 DEGKPMRRISYLRATNNETDFNAEAAAGGDAAATGASGPASASAASSAPGPTP------------ 824
            |.|:.......|.....::|.|...:..||..::|::....:..:......:|            
Zfish   171 DRGEKAAVQEELAEEGGDSDKNRIDSESGDELSSGSTDNLQSLGSGQGRPDSPVYTNLQEMKISQ 235

  Fly   825 SSAPAPAPAPAPLPISIPIPVAAVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGLEDVR 889
            ||.|       |||.|.||         .|....|.|.|        ..|.|.:.....      
Zfish   236 SSTP-------PLPSSSPI---------HTNGDWETHKD--------QNGRHYYYNRST------ 270

  Fly   890 LSAHGSRRASMSSDMRSSIHIDAELNGKYVPNELEAFE-TEIEIKSS---CINGKRMSEY----R 946
                 ..|.......|.|:           |.:.|..: |:.|:.||   |::.:..|:|    |
Zfish   271 -----QERTWKPPRARDSL-----------PRKEEKHDMTDTEVLSSEENCLSSQSDSQYGSPPR 319

  Fly   947 SWRQVKLEIKGDLLRI--------------------YSGRHAKSEHNVIELDIR----NFKFFDE 987
            .|.: :::..|..|.:                    ||...::||..:.::.::    :......
Zfish   320 GWSE-EMDEHGHTLYVCDYTNEKWLRHTDERGRLYYYSADGSRSEWELPKIGLKSQSNHTPLMPG 383

  Fly   988 SMDKKKYLIRMQSKPSPSGAHLASLGNELNLDEGHDKL-----------LTSSGSSSANEPAANA 1041
            .:.|.:.|.|....|.|..   .:..:.:...|.:|||           |....::..:.|....
Zfish   384 DLHKTRSLDRRLPDPIPIS---RTQRHSIYSHETNDKLKQKFVKVRQSFLPRRKTTLRSHPYFPQ 445

  Fly  1042 ASALTASTSSSTCSSGP--------YTEILFKTKSSNEMKRL-------FGLLQWKDSLNYDDNE 1091
            .:...:..|.|:|.|.|        ....|..||.:...|::       :.:|| ...|.::..:
Zfish   446 DTKTGSPDSDSSCPSSPKPPHSPSEKCATLNMTKITEHGKKVRKNWTSYWTVLQ-GSLLIFNKGQ 509

  Fly  1092 HQPQGKQLAEPQKTVASASYLDDVQGG----ASAADSSP---------------LSSHSGGIADA 1137
            ....| .....||  :|..|..|::||    ||...||.               |.|.|.|:.: 
Zfish   510 GGGSG-WFGRDQK--SSVEYSVDLKGGSVDWASKDKSSKKHVLELKTRQGTELLLQSDSDGLVN- 570

  Fly  1138 SGSHHVSALPAAAAIVAATSDSISPVMKARKSSSHKHIPDKDLGSPKSKNWKDLLFRRGGSGSGG 1202
              ..|.:...|....:..:.::|...| .....:.||  ||:.....||..:|:  ::..|....
Zfish   571 --DWHKALTEAIHTYMWESDEAIEEDM-PESPENEKH--DKEKDRKNSKKARDI--KKTASMDNA 628

  Fly  1203 VSHHD-------LASPSACAAKQIGSIGVPLRSCPMSKV----NAYVPHLVEVCTNIVETKGLGV 1256
            .....       |..|:..|.|..|.|...:..|.:|.:    |:.||..|.:|...||..||||
Zfish   629 EQKKKNKLVVLLLGRPTLQAVKDKGYIKDQVFGCSLSSLCQRENSTVPRFVWLCIEQVEKNGLGV 693

  Fly  1257 VGIYRIPGNKAAISELSELVNTKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYIN 1321
            .|:||:.||.|.|.:|...||.::   :....|.:|||::|.:..||:|.|.||:.|...:::.:
Zfish   694 DGLYRVSGNLAIIQKLRFAVNHEE---KIDLGDSKWEDIHVTTGALKMFFRELPEPLFTYTFFSD 755

  Fly  1322 FIEA----DKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGP 1382
            ||.|    |.|   :::..::::::.|||..::|::.|.:||.:|..:.|.|||..:::||:|||
Zfish   756 FISAIKMPDYK---QKVQTVKDLMKKLPRPNHDTIQVLFKHLKKVIQHVDENRMTTQSVAIVFGP 817

  Fly  1383 SIIRTPNDTLETAVKDMKHQCRIVELLVTQYDYFF 1417
            :::|...:|...|| .|.:|.:||||::.:||..|
Zfish   818 TLLRPEIETANMAV-HMVYQNQIVELILMEYDTIF 851

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP19DNP_001285496.1 PDZ_signaling <151..205 CDD:238492
RhoGAP_ARHGAP21 1221..1417 CDD:239860 70/203 (34%)
arhgap12aXP_021336423.1 SH3_ARHGAP12 11..70 CDD:213003
SH3-WW_linker 67..233 CDD:318759 25/126 (20%)
WW 252..278 CDD:306827 6/44 (14%)
PH_ARHGAP9-like 470..580 CDD:270053 24/116 (21%)
RhoGAP_ARHGAP27_15_12_9 660..846 CDD:239868 67/192 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23176
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2255
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
33.040

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