DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and arhgap32a

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	XP_690921.4	Gene:	arhgap32a / 562449	ZFINID:	ZDB-GENE-060503-918	Length:	1676	Species:	Danio rerio

Alignment Length:	1454	Identity:	304/1454 - (20%)
Similarity:	494/1454 - (33%)	Gaps:	455/1454 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   797 AAGGDAAATGA---SGPASASAASSAPGPTPS---------------------------SAPAPA 831
            |:...||||.|   :.|..||....:.||.|.                           .||...
Zfish     3 ASSRTAAATNARASTPPTDASTHDPSEGPHPEEDEGEEDRSLQPAETAGWEDAIAVMARGAPTVP 67

  Fly   832 PAPAPLPISIPIPVAAV-VEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGLEDVRLSAHGS 895
            ..||...:...:..|:: |:..|..||.:.|    :..:......|        .|:|..   ||
Zfish    68 ELPAESSLRSCVSTASMKVKNVKKLSLTKRH----FPKLAECAHFH--------YENVDF---GS 117

  Fly   896 RRASMSSDMRSSIHIDAELNGKYVPNELEAFETEIEIKSSCINGKRMSEYRSWRQVKLEIKGDLL 960
            .:.|::.:..     |...||      |::.|: :.:...|..|::.:..||:.:.::..|...|
Zfish   118 VQLSLTDEQN-----DLTNNG------LDSKES-VYLIQICCQGRKWTVRRSYEEFRVLDKHLHL 170

  Fly   961 RIYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPSGAHLASLG----NELN---- 1017
            .||..|.::         :......|...||...|.:|.:      |:::.|.    |::|
Zfish   171 CIYDRRFSQ---------LPELPRIDSLKDKTGTLSQMLT------AYISRLSAIADNKINCGPA 220

  Fly  1018 -----LDEGHDKLLTSSGSSSANEPAANAASALTASTSSSTCSSGPYTEILFKTKSSNEMKRLFG 1077
                 :|...:.||.:. .||.|.||..||..:                           ||.
Zfish   221 LTWMEIDNKGNHLLVND-ESSINVPAVAAAHVI---------------------------KRY-- 255

  Fly  1078 LLQWKDSLNYDDNEHQPQGKQLAEPQKTVASASYLDDVQGGASAADSSPLSSHSGGIADAS---G 1139
            :.|..|.|:::                       :.|:   .|..|..|..       |..   |
Zfish   256 IAQAADELSFE-----------------------VGDI---VSVIDMPPKE-------DTGWWRG 287

  Fly  1140 SH--HVSALPAAAAIVAATSDSISPVMKARKSSSHKHIPDKDLGSPKS-KNWKDLLFRRGGSGSG 1201
            .|  .|...|:...      :.||..:.:..:||        |..|.| |:.|.:.|.|....|
Zfish   288 KHGFQVGFFPSECV------ELISEKIPSNVTSS--------LAKPVSKKHGKLITFLRTFMKS- 337

  Fly  1202 GVSHHDLASPSACAAKQIGSIGVPLRSCPMSK--VNA--YVPHLVEVCTNIVETKGLGVVGIYRI 1262
                    .|:....||.|.:...:..|.:.:  :|:  .||.::..||..:|..|: |.||||:
Zfish   338 --------RPTKQKLKQRGILKERVFGCDLGEHLLNSGHDVPQVIRSCTEFIERHGV-VDGIYRL 393

  Fly  1263 PGNKAAISELSELVNTKDFQFES-----CASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYINF 1322
            .|..:.|.:|..       :|:|     ...|...:|::.|.||.||:.|.||:.|:....|..|
Zfish   394 SGISSNIQKLRH-------EFDSEHVPDLTKDTYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKF 451

  Fly  1323 IEA-----DKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGP 1382
            .:|     |.    ||:|.:.::::.||...|.|::.|:|||.|:....:|..|..|||||::.|
Zfish   452 SDAVSAATDD----ERLVKVHDVIQQLPPPHYRTLEFLMRHLSRMGTYSNVTNMHCKNLAIVWAP 512

  Fly  1383 SIIRTPNDTLE-------TAVKDMKHQCRIVELLVTQYDYFFEGGSLPDIAEV------------ 1428
            :::|:..  :|       :|..:::.|..:||.::...|..|.    |.::.:
Zfish   513 NLLRSKQ--IESACFSGTSAFMEVRVQSVVVEFILNHVDVLFS----PKLSTLIRHSTGHTTLAR 571

  Fly  1429 -------SGGTAAVSAAQPQQQTQEDQTSMLLHNLSKIERITERETTRTSRF-----MPQLRRK- 1480
                   |..|..:|..:.|.:||....|.:..: ||...:.|.......:|     .|..|:|
Zfish   572 PKSLLVSSPSTKLLSLEEAQARTQAQLNSPVSPD-SKYIDVGEGPAALQGKFHTVIDFPSERKKG 635

  Fly  1481 -THGKRSAVN-----------------------SDTYSGESVLVSGSSSNTTTTTTTTTHTTSST 1521
             |.||:|.|.                       |:....::..:.|...:|.|..:..:..:.|:
Zfish   636 STKGKKSPVGNWLSFFNMGKSSASAKPKLHRHPSEPNDMKTTPLPGGRGDTGTLRSAKSEESLSS 700

  Fly  1522 -----------------SSSNTITTTISTTTIQQR---------RAQRK-AVQSICDQALILLLP 1559
                             |:|:.::.:.:...:..|         :..|| ...|.|..|||   .
Zfish   701 SHNFEGGSNIYRPRRPLSTSDALSLSFNEELLDSRLTGDSRSSLKDHRKDTSSSSCVPALI---S 762

  Fly  1560 TPVSSVSLPF---QSLDYAKASASASASASSTASTSSSSTLHSGGKASASSSSSSTTKFSS---- 1617
            .|..|....|   .||| ....|..||......:....|...:|||......|:..|..|.
Zfish   763 PPHPSADAEFIGISSLD-IDPLAFQSARLVEQENKKKGSRKKAGGKNHELEPSNKVTSPSQPPDL 826

  Fly  1618 ----SSSSACSTTAVAISSSISATSSKLLSANFKKRSTGGFLGSRSSHQTRK--------ASLDE 1670
                :..|....:.:.:||:       .|...|.|  ||....||||.....        .||.:
Zfish   827 IPLRAEDSKHRPSELPLSST-------NLDVGFSK--TGQMGTSRSSVPKSSTVSCPSDIVSLMK 882

  Fly  1671 KDSGQSSGSLGHSLGVGINLAKEQQRSSVDISILLTDDDSSSRLSDTG------------SMSLT 1723
            |.|.......||....  :..|.:.:|:         |....|.:|:|            |:||.
Zfish   883 KPSVSMKAGEGHQRSA--SFCKTESKSA---------DVKQHRRADSGAVTFECTPGLVRSVSLI 936

  Fly  1724 TITDTLDSKLRNL-----RSGSESN--DENGSPEFPKNRRHTLGQPLHMHSENIPYADESPERLF 1781
            |....:.|..|.|     .|..::.  .:.||.|.|     |...|:|         .::|  ||
Zfish   937 TPQPAVKSAARMLALALAESAQQATRLSKRGSSEPP-----TPISPIH---------HKNP--LF 985

  Fly  1782 H-QFCNPLETAPLSLHLSRSCTATNTIGGDEKPSKQSGGVAPLPPSLLKA-----AHKLQHSATV 1840
            . ||..|::|:                 .|.:....|....|.|.|.:..     |..|:  :|.
Zfish   986 TLQFPPPVQTS-----------------SDREERYASNRAFPDPSSTMSTESHTDAGSLR--STC 1031

  Fly  1841 PIHQGSSTAPTS-GAATPVGTPTGSGGAGAIPSRSSSSSVTTLTKSIQPRFSNYLSYERGNAAAG 1904
            ..|...|....| |...|.|     |....:||:..|.......:.:|...:..    |.|....
Zfish  1032 ACHGSESGLSFSDGCDAPAG-----GQCTHVPSQGFSPRTDPEIQLVQETQTTL----RDNIRHV 1087

  Fly  1905 GAERVVGSAGGAASDD---DSEGSTTSDPKEKLLLGERPSPSFFIERYNKKRRDHRLFRSASFNC 1966
            |    ||:.||.:|.|   :..||..:...|:  .....|||.....:||:          :.|.
Zfish  1088 G----VGTDGGGSSLDAEMEVRGSLQTTLSER--YSSLDSPSAIDALHNKQ----------AANA 1136

  Fly  1967 RNYSTRHITAQTSGGVAAGVSGGVAGAVAVGVACCQALSTTGLTKDEKTDMNLTKKRQIQNKQNR 2031
            .|:  |.|.|:|            |...:|.....||.||..           :...|.:.::.|
Zfish  1137 ANF--RAILAET------------AMPASVQEVLPQASSTPP-----------SVLYQYKPREQR 1176

  Fly  2032 SIKRRHTVGGPHDYSASNGGCSNH 2055
            |...:|:    ..:|:|:|..:::
Zfish  1177 SAYSQHS----QQWSSSDGQSTSY 1196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	60/216 (28%)
arhgap32a	XP_690921.4	PX_domain	112..226	CDD:295365	27/143 (19%)
		SH3_ARHGAP32_33	248..301	CDD:212769	16/114 (14%)
		RhoGAP_CdGAP	353..547	CDD:239849	59/207 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940