DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and ARHGAP15

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_060930.3	Gene:	ARHGAP15 / 55843	HGNCID:	21030	Length:	475	Species:	Homo sapiens

Alignment Length:	466	Identity:	127/466 - (27%)
Similarity:	204/466 - (43%)	Gaps:	75/466 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1027 TSSGSSSANEPAANAAS---ALTASTSSSTCSSGPYTEILFKTKSSNEMKRLFGLLQWKDSLNYD 1088
            |..|:.:......||.|   .|:.|.|......|..||.:.:.:.::....|..::...:.|..:
Human    17 TRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVE 81

  Fly  1089 DNEHQPQ------GKQLAEPQKT---VASASYLDDVQGGASAADSSPLSSHSGGIADASGSH--- 1141
            ...:..:      ||:|.:...|   |.|:..::..:.....|.|:..:.|.....|..|:|
Human    82 KEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHIEW 146

  Fly  1142 --------HVSALPAAA-----------------------AIVAATSDSISP-----VMKARKSS 1170
                    :|..:...:                       ||.....||..|     :.|.::||
Human   147 AKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPKDSSCPSRNLELFKIQRSS 211

  Fly  1171 SHKHIP--DKDLGSPKSKNWKDLLFRRGGSGSGGVSHHDLAS---------PSACAAKQIGSIGV 1224
            |.:.:.  |.|:...|.::.|.|:||...|.|.....:.:.|         ||....::.|.|..
Human   212 STELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKD 276

  Fly  1225 PLRSCPMSKV----NAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSELVNTKDFQFES 1285
            .:....:.||    |:.||..|:.|...||.:||.|.||||:.||.|.|.:|..:||    |.|.
Human   277 QIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVN----QEEK 337

  Fly  1286 CASDD-RWEDVNVVSSLLKLFIRSLPDALMPASYYINFIEADKK-FGLERIVLLREIVESLPRHP 1348
            ...|| :|||::||:..||:|.|.||:.|.|.|::..|:||.|| ....||..::.:|:.||...
Human   338 LNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPN 402

  Fly  1349 YETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQY 1413
            .:|||.|..||.::......|.|..::|.|:|||:::|..|:|...|: .|.:|.:|.||::::|
Human   403 RDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAI-HMVYQNQIAELMLSEY 466

  Fly  1414 DYFFEGGSLPD 1424
            ...|  ||..|
Human   467 SKIF--GSEED 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	75/201 (37%)
ARHGAP15	NP_060930.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		2/5 (40%)
		PH	80..188	CDD:278594	13/107 (12%)
		PH_ARHGAP9-like	81..190	CDD:270053	15/108 (14%)
		RhoGAP_ARHGAP27_15_12_9	279..465	CDD:239868	73/190 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010