DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP19D and arhgap12b

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	XP_021335715.1	Gene:	arhgap12b / 393848	ZFINID:	ZDB-GENE-040426-1727	Length:	882	Species:	Danio rerio

Alignment Length:	1041	Identity:	213/1041 - (20%)
Similarity:	363/1041 - (34%)	Gaps:	352/1041 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   558 STAPGSVCHQHQQQQQHHLYHQQQHQQLQQTQHRQVMINNNAKY----AKDLDYFETLQETGVTN 618
            |.|||.|            |.:.::....:.:.:.:.|.....|    ..:.|:::..:|.|...
Zfish    11 SIAPGQV------------YIEVEYDYEYKAKDKLISIRQGECYMLVRKTNEDWWQVRREEGTKA 63

  Fly   619 KVFERKLVSHMSKG-FDPFKPLSINTSALESSASTSSTSATTTVKKQSVLYESLQQHPLAKYHQT 682
            .....:.|..:.:. ..|.||.:...:.||.:...||.             |:|.|..     .|
Zfish    64 FYVPAQYVREVRRALMPPPKPRAKPPNVLEITHCRSSN-------------ENLNQRA-----PT 110

  Fly   683 QQQT-------TTTTTVDGQTSSRMELH--------KATLANATI------------DPVPVGSS 720
            ::.|       ||.:.:.||.:..:.|.        |:.:|..|:            :|
Zfish   111 EKSTFGRPPPSTTPSPLPGQQTPPLLLRDSNHNPGMKSVVAELTLLNNNNHHNFHHANP------ 169

  Fly   721 KFVTLP----DKPDK----------GSSVATLADIAESSAAAIVDSASGSGNVVRRYKPLSSSSF 771
               |||    :.|.:          |.||.|...::.......:.:.|.||:      .|||||.
Zfish   170 ---TLPQGRAESPPRDQGCQGKLTGGLSVDTDGSVSPGDGVEKMRNDSESGD------ELSSSST 225

  Fly   772 D---------EGKP---------------------------------------MRRISYLRATNN 788
            :         :|:|                                       ..|..|...|..
Zfish   226 EHIQSVSLSGQGRPESPVYTNLQELKICQSSVPPVPSTSPLHVLGDWETHKDTSGRNFYFNRTTQ 290

  Fly   789 ETDFNA-----EAAAGGDAAATGASGPASASAASSAPGPTPSSAPAPAPAPAPLPISIPIPVAAV 848
            |..:..     ...:.||.:.||...|.|:.  .:.|....|.:.:...:|
Zfish   291 ERTWKPPRSRDNGVSRGDTSNTGDMEPLSSE--ENCPSTHSSQSDSQYGSP-------------- 339

  Fly   849 VEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGLEDVRLSAHGSRRASMSSDMRSSIHIDAE 913
              |:.....::||             ||                              ::::...
Zfish   340 --PRGWSEELDEH-------------GH------------------------------TLYVSEY 359

  Fly   914 LNGKYV--------PNELEAFETEIEIKSSCINGKRMSEYRSWRQVKLE----IKGDLLRIYSGR 966
            .|.|::        |....|            :|.| ||   |...|..    |.|:..:.:|..
Zfish   360 TNEKWIKHVDEQGRPYYYSA------------DGSR-SE---WELPKYNLSPPISGEAPKSHSLE 408

  Fly   967 HAKSE--------HNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPSGAHLASLGNE---LNLDE 1020
            ..:.|        |:...|||.:    .||::.|.......|.|| |..|.::...:   ||:.:
Zfish   409 RKQQEPIVLTKWRHSTYVLDISD----KESVNAKPNSPESDSCPS-SPKHPSTPSEKCGVLNVTK 468

  Fly  1021 --GHDKLLTSSGSSSANEPAANAASALTA-----STSSSTCSSGPYTEILFKTKSSNEMKRLFGL 1078
              .|.|.:..:.:|:..  ....:|.|.|     .||.|.|.:|.:.|:|....|:
Zfish   469 ITEHGKKVRKNWASTWT--VLQGSSLLFAKGQGSGTSWSYCHNGSFPELLLSLLSN--------- 522

  Fly  1079 LQWKDSLNYDDNEHQPQ----------------GKQLAEPQKTVASASYLDDVQGGASAADSSPL 1127
              ||.|:       :|:                |...::|:.||       |::||:....|.
Zfish   523 --WKRSI-------KPRPAVSYTHCRRARASSFGGNQSKPEFTV-------DLRGGSVEWASK-- 569

  Fly  1128 SSHSGGIADASGSHHVSALPAAAA---IVAATSDS-ISPVMKARKSSSHKHIPDKD--------- 1179
                    :.|...||..|.....   ::.:..|| |:...:|...:.:.|..:.|
Zfish   570 --------EKSSKKHVIELKTRVGTELLIQSEIDSVINDWFRALSETINTHAWESDEAIEEDMPE 626

  Fly  1180 -LGSPKSKNWKDLLFRRGGSGSGGVSHHDLAS-----------------PSACAAKQIGSIGVPL 1226
             .||.|....||   .|....:..|.:..:.|                 |:..|.:..|.|...:
Zfish   627 SPGSEKHDKEKD---PRDSKKNRVVKNSSMESSEQKKTRVKLKKFLTRRPTLQAVRDKGYIKDQV 688

  Fly  1227 RSCPMS----KVNAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSELVNTKDFQFESCA 1287
            ..|.::    :....||:.|::|...||..||.|.|:||:.||.|.|.:|...||..:   :...
Zfish   689 FGCSLTALCQREGTSVPNFVKMCIEHVENTGLNVDGLYRVSGNLAVIQKLRFAVNHDE---KVNL 750

  Fly  1288 SDDRWEDVNVVSSLLKLFIRSLPDALMPASYYINFIEADKKFGL-ERIVLLREIVESLPRHPYET 1351
            .|.:|||::|.:..||:..|.||:.|...:.:.:|:||.|.... :|:..::::::.||:...||
Zfish   751 DDSKWEDIHVTTGALKMLFRELPEPLFTYASFNDFVEAIKNSDYKQRVQSIKDLIKQLPKPNQET 815

  Fly  1352 MKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQYDYF 1416
            ||.|.:||.||..:.:||||..:::||:|||:::|...:|...|| .|.:|.:||||::.:|:..
Zfish   816 MKVLFKHLKRVIDHGEVNRMTTQSVAIVFGPTLLRPEIETGNMAV-HMVYQNQIVELILLEYENI 879

  Fly  1417 F 1417
            |
Zfish   880 F 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	68/200 (34%)
arhgap12b	XP_021335715.1	SH3_ARHGAP12	17..76	CDD:213003	8/70 (11%)
		SH3-WW_linker	73..267	CDD:318759	39/226 (17%)
		WW	271..297	CDD:306827	4/25 (16%)
		WW	364..389	CDD:306827	7/40 (18%)
		PH_ARHGAP9-like	459..611	CDD:270053	36/188 (19%)
		RhoGAP_ARHGAP27_15_12_9	689..875	CDD:239868	66/189 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010