DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and Arhgap9

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	XP_006241526.1	Gene:	Arhgap9 / 362893	RGDID:	1305342	Length:	642	Species:	Rattus norvegicus

Alignment Length:	820	Identity:	165/820 - (20%)
Similarity:	273/820 - (33%)	Gaps:	309/820 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   642 NTSALESSASTSSTSATTTVKKQSVLYE-SLQQHPLAKYHQTQQQTTTTTTVDGQT--SSRMELH 703
            :.|....:.||.::|..|...|   ||. ||:...|::.||         .|.||.  .|.....
  Rat    87 SVSCHNPAGSTHNSSLWTPGTK---LYRGSLEDLYLSQEHQ---------VVSGQPPHCSHKMCR 139

  Fly   704 KATLAN---ATIDPVPVG-SSKFVTLPDKPDKGSSVATLADIAESSAAAIVDSASGSGNVVRRYK 764
            ..::||   .::.|...| ..:|::......:.|:.|..:...|.:.|.|.||     |.::..:
  Rat   140 SVSMANVKLCSLKPFKEGPQERFLSQDCWRTEASAAAVKSGSMEHTEALIRDS-----NPLQHQE 199

  Fly   765 PLSSS---SFDEGKPMRRISYLRATNNETD--FNAEAAAGGDAAATGASGPASASAASSA----- 819
            .|::.   |..:..|...:|.....:.|..  .|....|.|......:.|||......::
  Rat   200 WLNAQDLPSLSQSIPWPDVSEQPCPHEERSGLLNMTKIAQGGRKLRKSWGPAWVVLTGNSLVFYR 264

  Fly   820 --PGPTPSSAPAPAPAPAPLPISIPIPVAAVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETP 882
              |   |..||:...|||.                                           ..|
  Rat   265 ERP---PQCAPSQGWAPAG-------------------------------------------SRP 283

  Fly   883 NGLEDVRLSAHGSRRASMSSDMRSSIHIDAELNGKYVPNELEAFETEIEIKSSCINGKRMSEYRS 947
            ....|:|.:|..|.|  ..|..|:.:||      :.||......:::.|           :|.|:
  Rat   284 ESSVDLRGAALASGR--QLSSRRNVLHI------RTVPGHEFLLQSDEE-----------TELRA 329

  Fly   948 WRQVKLEIKGDLLRIYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPSG-AHLAS 1011
            |.:....:...|:|       :...|.:||.:                       |.|| |.||.
  Rat   330 WHRALRAVIERLVR-------RDRENPLELRL-----------------------SGSGPAELAE 364

  Fly  1012 LGNELNLDEGHDKLLTSSGSSSANEPAANAASALTASTSSSTCSSGPYTEILFKTKSSNEMKRLF 1076
            |..      |.|..|.|       ||.:.:...|.:..:||.|:.|...    |.:..|::|||
  Rat   365 LSG------GEDDELES-------EPVSKSLMRLGSRRTSSRCAEGTDQ----KNRVRNKLKRL- 411

  Fly  1077 GLLQWKDSLNYDDNEHQPQGKQLAEPQKTVASASYLDDVQGGASAADSSPLSSHSGGIADASGSH 1141
                                         :|....|..:|
  Rat   412 -----------------------------IAKRPTLQSLQ------------------------- 422

  Fly  1142 HVSALPAAAAIVAATSDSISPVMKARKSSSHKHIPDKDLGSPKSKNWKDLLFRRGGSGSGGVSHH 1206
                                               ::.|       ::|.:|
  Rat   423 -----------------------------------ERGL-------FRDQVF------------- 432

  Fly  1207 DLASPSACAAKQIGSIGVPLRS-CPMSKVNAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAIS 1270
                            |..|.| |  .:....||..|.:|...|:.|||.|.||||:.||.|.:.
  Rat   433 ----------------GCQLESLC--QREGDTVPSFVRLCVEAVDKKGLDVDGIYRVSGNLAVVQ 479

  Fly  1271 ELSELVNTKDFQFESCASDDR-------------------WEDVNVVSSLLKLFIRSLPDALMPA 1316
            :|..||:.:    .:..||.|                   |:|::|::..||||.|.||..|:||
  Rat   480 KLRFLVDRE----RAVTSDGRYMFPEQPGQEGKLDLDSAEWDDIHVITGALKLFFRELPQPLVPA 540

  Fly  1317 SYYINFIEA----DKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLA 1377
            ....:|.:|    :.:..|.:|   :::::||||..::|:::::.|||||..:.|.|||...||.
  Rat   541 LLLPHFRDALELSEPEHCLSKI---QKLIDSLPRPNHDTLQYILEHLCRVIAHSDKNRMTAHNLG 602

  Fly  1378 IIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQYDYFF 1417
            |:|||::.|...:..:.|. .:.:..::::|::..:...|
  Rat   603 IVFGPTLFRPEQEASDMAA-HVVYPGQLIQLMLNNFASLF 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	66/219 (30%)
Arhgap9	XP_006241526.1	SH3	27..82	CDD:302595
		PH_ARHGAP9-like	227..340	CDD:270053	30/177 (17%)
		PH	241..339	CDD:278594	26/162 (16%)
		RhoGAP_ARHGAP27_15_12_9	432..636	CDD:239868	67/242 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010