DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and CdGAPr

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_001260600.1	Gene:	CdGAPr / 35267	FlyBaseID:	FBgn0032821	Length:	1843	Species:	Drosophila melanogaster

Alignment Length:	1589	Identity:	325/1589 - (20%)
Similarity:	508/1589 - (31%)	Gaps:	510/1589 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   696 TSSRMELHKATLANATIDPVPVGSSKFVTLPDKPDKGSSVATLADIAESSAAAIVDSASGSGNVV 760
            ||...:||...||:|....:...:...:......||.:....|....::.||||  ||..:..:|
  Fly     7 TSLAAQLHSHALASAEAGGIGGVNGGPIACHASTDKDAQAPPLQFEMDAPAAAI--SAQLNFKIV 69

  Fly   761 RRYKPLSSSSFDEGKPMRRISYLRATNNETDFNAEAAAGGDAAATGASGPASASAASSAPGPTPS 825
                |..|        :..:||      :..|          |:...|..::||..||...|...
  Fly    70 ----PADS--------LPGLSY------QDMF----------ASMNTSQISNASTESSCSPPIQG 106

  Fly   826 SAPAPAPAPAPLPISIPIPVAAVVEPQKTKSL----VEEHPDPTYDVIGGTGGGHEFIETPNGLE 886
            :.|.|.|:.           ...|:|..:||.    :||.....|:            ....|..
  Fly   107 AVPPPKPSR-----------HMAVQPLNSKSCRFPKLEECAHFHYE------------RVQLGPL 148

  Fly   887 DVRL----SAH-GSRRASMSSDMRSSIHIDAELNGKYVPNELEAFETEIEIKSSC-----INGKR 941
            .|:|    |.| ||..||.|            |.|....:.|.:|..|     ||     :..:|
  Fly   149 SVQLLDDKSEHMGSSIASQS------------LGGDLPHSSLRSFSPE-----SCWFIIRVCPQR 196

  Fly   942 MSEY---RSWRQVKLEIKGDLLRIYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKPS 1003
            ...:   ||:..::| :...|.|....|......|:.||........|......|||.|. ||.:
  Fly   197 CEPFLIKRSFENMQL-LDEMLHRCVYDRKISGLRNMEELAAELPSESDVEYAVAKYLERF-SKIA 259

  Fly  1004 PSGAHLASLGNELNLDEGHDKLLTSSGSS--SANEPAANAASAL--------------TASTSSS 1052
            .......::...|.||....:|..:.|.:  :.|.||..||..:              .....|.
  Fly   260 SDSLTCGTILTWLQLDNKGRRLPLADGETQRTINTPAVGAAYGVRRYQAQAPDEINIEVGDMISV 324

  Fly  1053 TCSSGPYTEILFKTKSSNEMKRLF--GLLQWKDSLNYDDNEHQPQGKQLAEPQKTVASASYLDDV 1115
            .....|...|.::.|.|:..|.|:  |..                      ||..||:.
  Fly   325 IDMPSPAESIWWRGKKSHLQKSLYEVGFF----------------------PQSCVATI------ 361

  Fly  1116 QGGASAADSSPLSSHSGGIADASGSHHVSALPAAAAIVAATSDSISPVMKARKSSSHKHIPDKDL 1180
              |.....:.|:.:...|..|||.:                    .||::
  Fly   362 --GDKVPRNFPMPAPLVGHLDASPT--------------------KPVLR--------------- 389

  Fly  1181 GSPKSKNWKDLLFRRGGSGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSK--VNA--YVPHL 1241
                 |:.|.:.|.|.         ..|:.||....||.|.....:.:|.:|:  :|:  .:|.:
  Fly   390 -----KHGKLIAFFRS---------FILSRPSRRRLKQSGIYRERVFNCDLSEHLLNSGQDIPMV 440

  Fly  1242 VEVCTNIVETKGLGVVGIYRIPGNKAAISELSELVNTKDFQFESCASDDRWEDVNVVSSLLKLFI 1306
            :..|...:|..|: :.||||:.|..:.|..|....:.:  :.....:.:..:|::.||||||::.
  Fly   441 LRSCAEFIENYGV-IDGIYRLSGITSNIQRLRRAFDEE--RVPDLGNPEMKQDIHAVSSLLKMYF 502

  Fly  1307 RSLPDALMPASYYINFIE-----ADKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNC 1366
            |.||:.|.....|.||:|     ||:  ..||:.|::|.|..||...|.|:|:|..||.:||.:.
  Fly   503 RELPNPLCTYQLYDNFVEAIQVKADE--ADERLRLMKETVLKLPPPHYRTLKYLAEHLYKVSQHH 565

  Fly  1367 DVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQYDYFFEGGSLPDIAEVSGG 1431
            ....|..|||||::.|:::|:|  .||                                   |||
  Fly   566 GRTGMTDKNLAIVWAPNLLRSP--ALE-----------------------------------SGG 593

  Fly  1432 TAAVSAAQPQQQTQEDQTSMLLHNLSKIERITERETTRTSRFMPQLRRKTHGKRSAVNSDTYSGE 1496
            .||:.....|...    |..|:.|...|....:....|.|..         ...:|..::...||
  Fly   594 VAALRGVGVQAVV----TEYLIRNCHNIFDALDDHPARHSMV---------ASATAAAANAAGGE 645

  Fly  1497 SVLVSGSSSNTTTTTTTTTHTTSSTSSSNTITTTISTTTIQQRRAQRKAVQSICDQALILLLPTP 1561
            ..|.|                          .|...:..::||...
  Fly   646 LRLES--------------------------LTDCESLLVEQREQD------------------- 665

  Fly  1562 VSSVSLPFQSLDYAKASASASASASSTASTSSSSTLHSGGKASASSSSSSTTKFSSSSSSACSTT 1626
                    |||...:...|.|...:...|...:...||..:.:....|...:..:|:||:|.|..
  Fly   666 --------QSLGVVERPKSLSTGGAKLISLEEAQERHSRVEGADLKQSLPISMLTSASSNAASNI 722

  Fly  1627 AVAIS-----SSISATSSKLLSA--NFKKRS-----TGGFLGSRSSHQ-----TRKASLDEKDSG 1674
            ...|.     ||:......:|||  :::||.     :...:.|||..|     .:|.:.|.|||.
  Fly   723 GSYIEVGGGPSSLPDKYHTVLSAPRSWQKRKPDKTPSWKSIFSRSQRQGNPDPGQKITTDVKDSV 787

  Fly  1675 QSSGSL---GHSLGVGINLAKEQQRSSVDISILLTDDDSSSRLSDTGSMSLTTITDTLDSKLRNL 1736
            .|..|.   .|:     :.:||..:.....||.|.:..|:.|  |...|.|...::::|| ||.:
  Fly   788 ASRVSFVQASHA-----HASKELTKHDKPKSIELLETTSNER--DPKPMDLCIRSNSIDS-LRTV 844

  Fly  1737 -RSGSESNDENGSPEFPKNRRHTLGQPLHMHSENIPYAD--ESPERLFHQFCNPLETAPLSLHLS 1798
             .|.|.|:|.                          |.|  :||:|.....|...|.:.|.|:..
  Fly   845 GHSRSVSHDS--------------------------YFDLLQSPQRGHMTTCPSRELSELGLNFD 883

  Fly  1799 RSCTATNTIGGDEKPSKQSGGVAPLPPSLLKAAHKLQHSATVPIHQGSSTAPTSGAATPVGTPTG 1863
            |           |:|..:                         |...|.:..:|........|..
  Fly   884 R-----------EEPEMR-------------------------IFSESESLVSSPRVGKENVPPA 912

  Fly  1864 SGGAGAIPSRSSSSSVTTLTKSIQPRFSNYLSYERGNAAAGGAERVVGSAGGAASDDDSEGSTTS 1928
            ||.|.....|:.....::.|.|:.|                                    |...
  Fly   913 SGSATRRIMRARPEDFSSQTNSVNP------------------------------------SPKK 941

  Fly  1929 DPKEKLLLGERPSPSFFIERYNKKRRDHRLFRSASFNCRNYSTRHITAQTSGGVAAG-VSGGVAG 1992
            .|:..||     |||                     :.|......::|..:...:.| .|||...
  Fly   942 QPRLNLL-----SPS---------------------SARTMPPPPLSAPGTASSSCGHESGGAEN 980

  Fly  1993 AVAVGVACCQALSTTGLTKDEKTDMNL----TKKRQIQNKQNRSIKRRHTVGGP-----HDYSAS 2048
                   ||:...    .:|:..|:..    |.:.....:|..:....|....|     ...|:|
  Fly   981 -------CCKRYK----LEDQLCDIQFIDCGTPENVPTTQQQFASVEVHPPPKPARANQSPISSS 1034

  Fly  2049 NG---GCSNHSHGHDLAAINYNHHNRHHQ---QQLLKLGSATSGGGGSGAAAAETTTTTTTTTTV 2107
            ||   |.|:.|..:...::......:..|   ::....|:.|..|....::|.....:|....|
  Fly  1035 NGASVGSSSSSTRYSYPSVQLGAKRKEQQDAKERFSYQGTFTQPGQKQESSAPRPVHSTNNGAT- 1098

  Fly  2108 LRR-----LGTGQ------------AGAEASVALPASSSGSSSNNNNSPQSDGS----NGNGGGV 2151
            ||:     :..||            .....|:.|..:.|..:|:..|:||.|..    .....||
  Fly  1099 LRKPRVEPVEDGQIKLHVPTPTTPARSPRYSLLLCDTESSDNSSAVNTPQYDMEPLMLTSAMSGV 1163

  Fly  2152 AGVASNAPPTGVGVGGNNSS---GSSSNS 2177
            :||:||.....:.:|.:.||   |||..|
  Fly  1164 SGVSSNVQQQQLLLGVDASSSYLGSSHES 1192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	57/204 (28%)
CdGAPr	NP_001260600.1	PX_domain	168..274	CDD:295365	26/124 (21%)
		SH3_ARHGAP32_33	299..358	CDD:212769	12/80 (15%)
		RhoGAP_CdGAP	420..613	CDD:239849	65/238 (27%)
		FliJ	1322..1457	CDD:304890
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.940