DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and arhgap21b

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	XP_001918968.3	Gene:	arhgap21b / 326745	ZFINID:	ZDB-GENE-030131-4944	Length:	1793	Species:	Danio rerio

Alignment Length:	2262	Identity:	484/2262 - (21%)
Similarity:	747/2262 - (33%)	Gaps:	861/2262 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PKLIVIRRRPNQGFGFTLRHFIAYPPEDDQASSSASGLVSGSATAATAASVSTNWPQEASSAAGS 116
            ||::.: ||.:|||||||||||.||||                     :::.:|:..|..|..|.
Zfish    50 PKILRL-RRTSQGFGFTLRHFIVYPPE---------------------SAMHSNFKDEDHSHRGR 92

  Fly   117 NSGSSSSVGVAGITGLEPTSPTSLPPYQVKAMETIFIKEVQANGPAHYANLQTGDRVLMVNNQPI 181
                                    |..:::.|:|||:|:|:..||||.|.|.||||::.||.:.|
Zfish    93 ------------------------PRNRLEPMDTIFVKQVKEGGPAHSAGLCTGDRIVKVNGESI 133

  Fly   182 AGIAYSTIVSMIKQTPAVLTLHVVPKECDVLQMHYTSIA-------------HTPESNRL----- 228
            .|..||.::.:|:.:...|.|.|:||:.|:||:.|:..|             |.||...:
Zfish   134 IGKTYSQVIGLIQNSHTFLELCVMPKDEDILQLAYSQDAYLKGHDAYSGNARHIPEPPPICYPRV 198

  Fly   229 ---------TMSTHSPSLLANG-SHKTTFP---------------------AAAAVAAPPHQHQQ 262
                     ...|.:|.::::. .::...|                     :...|..||..|..
Zfish   199 DCKPPGMAQATETSAPGVVSSDLGYRVEIPVPPSPPPPIPKTQTAVCVCNESVRTVVVPPDVHMG 263

  Fly   263 QQQQ-------LIS-YPAVAAVTTSTPAGS------PQSQSQSQSHSH------PNTHHAPSLHG 307
            ...|       |:. .|.:......|.:|.      |:......|..|      |.||:.|
Zfish   264 LMVQGHRGDYGLVGPDPMLIRARPGTVSGGRPPYLHPRKADMFPSGYHGDPYAIPPTHYVP---- 324

  Fly   308 GSRSGSITSTASGGITVLSQPFYPQQQQQQQQQQQHRHPALTGGSSSIDFGDMAHGLRQHQQQQQ 372
               :.||||.|:                                               ||....
Zfish   325 ---ASSITSPAT-----------------------------------------------HQNIDW 339

  Fly   373 HLYQQQQQH------HQFMRANQPPNLTVLSASSATNTPTPTARQP-------KSATSHNQALYA 424
            ..||..:::      |.:.|..|....::.:||.:|:.......||       :.:|||::|.
Zfish   340 RTYQTYREYIDNKGIHAYSRTVQERLDSLRAASQSTHGGPHCGPQPGWGNKLRRRSTSHDRAY-- 402

  Fly   425 VGAGPSSAAGSGSGSLSGGSENSDLMIRLRESIKQKEEFLKSPVPASMSSASSINGNQAQSS--- 486
              .|||        .|...|.:.|     |.|..::....:...|.|:||...|...:|.||
Zfish   403 --QGPS--------MLPPRSASQD-----RMSGAERAAHARDWPPRSVSSDGLIRKPRAHSSDYV 452

  Fly   487 ------------SPAQQQHLQQHQQHFFPSH--TPPGGVQVVVPPPRSRHQVMLKQQQQQQQQHQ 537
                        :|..:|...:..|...||.  .||..  |:..||
Zfish   453 EHGELVSAAPWAAPVDRQLYSRVDQRSRPSRQSLPPRA--VLYRPP------------------- 496

  Fly   538 QHHVLGYDMYHSGGKLVQRSSTAPGSVCHQHQQQQQHHLYHQQQHQQLQQTQHRQVMINNNAKYA 602
                .||.|...|.         .||  |:|..:           ..:..|........|....|
Zfish   497 ----TGYGMSVRGN---------AGS--HKHSSR-----------TDIPPTAGFPERPRNGINQA 535

  Fly   603 KDLDYFETLQETGVTNKVFERKLVSHMSKGFDPFKPLS---INTSALESSASTSSTSATT----- 659
            |:                             .|.|..|   :....|.|:::.|.|.|.|
Zfish   536 KE-----------------------------PPSKDQSGTVVGNRILNSASNQSRTRAETMQSPE 571

  Fly   660 TVKKQSVLYESLQQHPLAKYHQTQQQTTTTTTVDGQTSSRMELHKATLANATIDPVPV-GSS--K 721
            :.|..||.|.|      |.|.....|.........:||||           .:..:|| |||  :
Zfish   572 SGKDISVGYRS------ASYSAPPLQRPKGGASTQRTSSR-----------DVKGLPVNGSSPVE 619

  Fly   722 FVTLPDKPDKGSSVATLADIAESSAAAIVDSASGSGNVVRRYKPLSSSSFDEGKPMRRISYLRAT 786
            .|.|.:||..|....                                      :|:|..||:.|.
Zfish   620 GVVLREKPPTGKGTP--------------------------------------QPLRHPSYILAV 646

  Fly   787 NNETDFNAEAAAGG---------------------DAAATGAS------------GPASASA--- 815
             |:|| .:|.|.||                     |::...::            .|||.|.
Zfish   647 -NDTD-GSEPAGGGVCWLPNDARREMRMQRLGERLDSSFCSSNLDESLDSIPFIDEPASPSVDHD 709

  Fly   816 ASSAPGPTPSSAPAPAPAPAPLPISIPIPVA-------------AVVE----PQKTKSLVEEHPD 863
            .|..|.....|....|.:.:|.| |.|.|:.             |::|    .:::||
Zfish   710 GSHIPASVVISGAQAALSDSPSP-STPSPLMRRQLSHDQESLRNAILESGTKTERSKS------- 766

  Fly   864 PTYDVIGGTGGGHEFIETPNGLEDVR------------------LSAHGSRRASMSSDMRSSIHI 910
              ||               .||::.|                  |..|.|..:|...|..:.|..
Zfish   767 --YD---------------EGLDNYREEGRGRSSKPSLRVFRKALDGHKSDDSSSRRDSSTEIFS 814

  Fly   911 DAELNGKYVPNELEAFETEIEIKSSCINGKRM-SEYRSWRQVKLEIKGDLLRIYSGRHAKSEHNV 974
            |:...|..   ......||        .|||: ...|.|:|:...::|..|.:|.
Zfish   815 DSTKEGWL---HFRQLNTE--------KGKRVGGGMRPWKQMYAVLRGHSLYLYK---------- 858

  Fly   975 IELDIRNFKFFDESMDKKKYL--IRMQSKPSPSGAHLASLGNELNLDEGHDKLLTSSGSSSANEP 1037
                           |||:.|  :..|.:..|....:.:.            |:..|.|.:..:
Zfish   859 ---------------DKKEGLAHVNSQLEDDPQSISIKAC------------LIDISYSDTKRK- 895

  Fly  1038 AANAASALTASTSSSTCSSGPYTEILFKTKSSNEMKRLFGLLQWKDSLNYDDNEHQPQGKQLAEP 1102
                 :.|..:||.  |      |.||:.:...:|      |.|...:..:.|        |.|.
Zfish   896 -----NVLRLTTSD--C------EYLFQAEGREDM------LSWIRVIQENSN--------LDEE 933

  Fly  1103 QKTVASASYLD-------DVQGGASAADSSPLSSHSGGIADASGSHHVSALPAAAAIVAATSDSI 1160
            ...|.|...::       .:...:|..:.||.:|.             .:|.....::..:|.|.
Zfish   934 NAAVTSTDLINRKLKEYISMSAPSSKTEPSPKTSR-------------QSLSIRQTLLGGSSKSQ 985

  Fly  1161 SPVMKARKSSSHKHIPDKDLGSPKSKNWKDLLFRRGGSG----------SGGVSHHDLASPSACA 1215
            ||.....:....|    .|...|:.|    ..:|||..|          :.||
Zfish   986 SPYSPKNEQDRSK----DDSSPPRDK----AAWRRGIPGLKKKPQDKRPAAGV------------ 1030

  Fly  1216 AKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSELVNTK- 1279
                 :.||.|.:||.::.|.:||.:||||..:||.:||...||||:|||.||||.:.|.::||
Zfish  1031 -----TFGVRLDNCPPAQTNKFVPLIVEVCCKLVEDRGLEYTGIYRVPGNNAAISSMQEELDTKG 1090

  Fly  1280 ----DFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYINFIEADK-KFGLERIVLLRE 1339
                |.|      ||:|.|:||:|||||.|.|.||:.|.....|.|||:|:: :..:||:..|:.
Zfish  1091 MTDIDIQ------DDKWRDLNVISSLLKSFFRKLPEPLFTNEKYSNFIDANRMEDPVERLKALKR 1149

  Fly  1340 IVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCR 1404
            ::..||.|.|||:|.|..||..||.||:.|:|||:||||:|||:::||..|.:...|..|..|.:
Zfish  1150 LIHELPDHHYETLKFLSGHLKTVSENCEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYK 1214

  Fly  1405 IVELLVTQYDYFFE--------------------------------GGSLPDIAEVSGGTAAVSA 1437
            |||.|:.|||:||.                                |.:.|...:||..|.:.||
Zfish  1215 IVETLIQQYDWFFTEDGDEEPTTTVEQESTVQSQPVPNIDHLLTNIGRTAPSPGDVSDSTTSDSA 1279

  Fly  1438 AQPQQQ--TQEDQTSMLLHNLSKIERITERETTRTSRFMPQLRRKTHGKRSAVNSDTYSGESVLV 1500
            ...|..  |.:||.|              .|..|||.|..:.|:|...|....:||    :.:..
Zfish  1280 KSKQGSWGTGKDQYS--------------SELLRTSIFASRKRKKPKDKPQPSSSD----DDLDA 1326

  Fly  1501 SGSSSNTTTTTTTTTHTTSSTSSSNTITTTISTTTIQQRRAQRKAVQSICDQALILLLPTPVSSV 1565
            |.|..:..............|..:.      |...:..:|.:..      ||       :|...:
Zfish  1327 SFSKKDLPVQNDPNWPADDQTEDAE------SEVGLDDQRTEDD------DQ-------SPGDGL 1372

  Fly  1566 SLPFQSLDYAKASASASASASSTASTSSSSTLHSGGKASASSSSSSTTKFSSSSSSACSTTAVAI 1630
            .|..::..............||..:||...:.|       .:..||.:...|:....|    |:.
Zfish  1373 DLTSENKQLITEHLPQQTCPSSKINTSPKPSYH-------MTRQSSLSDHPSNYDDGC----VSD 1426

  Fly  1631 SSSISATSSKLLSANFKKRSTGGFLGSRSSHQTRKASLDEKDSGQSSGSLGHSLGVGINLAKEQQ 1695
            ..::::|||                         :||:.....|:::|....|.|:|:
Zfish  1427 LGTLNSTSS-------------------------QASVPRIRHGRTTGHWMESAGMGL------- 1459

  Fly  1696 RSSVDISILLTDDDSSSRLSDTGSMSLTTITDTLDSKLRNLRSGSESNDENGSPEFPKNRRHTLG 1760
              ..::..:.:|      .|.|.||:..|..::: :....::|.:||..::
Zfish  1460 --GAEVCSITSD------YSTTSSMTFHTGVESI-ALSPEVQSVAESRGDD-------------- 1501

  Fly  1761 QPLHMHSENIPYADESPERLFHQFCNPLETAPLSLHLSRSCTATNTIGGDEKPSKQS----GGVA 1821
                        ||:....|..: ..|:||.      |.|..:...:|.|..|::.|    |.|.
Zfish  1502 ------------ADDERSELISE-GRPMETD------SESDLSVFAVGRDGVPAEDSSQLGGSVT 1547

  Fly  1822 PLP--PSLLKAAHKLQHSATVPIHQGSSTAPTSGAATPVGTPTGSGGAGAIPSRSSSSSVTTLTK 1884
            ||.  |||: .:|::....|:...:||...          |.:.|...|   |||...|.
Zfish  1548 PLQDVPSLI-PSHRIIACDTLARKRGSRQK----------TDSESSADG---SRSDKEST----- 1593

  Fly  1885 SIQPRFSNYLSYERGNAAAGGAERVVGSAGGAASDDDSEGSTTSDPKEKLLLGERPSPSFFIERY 1949
                |.|..|            |.|.|.:.|:.|......|..::|..::.:.:|
Zfish  1594 ----RISRVL------------EAVKGRSTGSLSSSSRSESERAEPMWRIKITDR---------- 1632

  Fly  1950 NKKRRDHRLFRSASFNCRNYSTRHITAQTSGGVAAGVSGGVAGAVAVGVACCQALSTTGLTKDEK 2014
                          ..||        .:||.....||..
Zfish  1633 --------------LKCR--------LRTSADDMFGVGS-------------------------- 1649

  Fly  2015 TDMNLTKKRQIQNKQNRSIKRRHTVGGPHDYS-ASNGGCSNHSHGHDLAAIN 2065
               ..|:..:.::|:..:|:||||:||..|:: .|..|......|::|:|::
Zfish  1650 ---QRTRSPETRSKRKSNIRRRHTMGGQRDFAELSVIGDWQRVEGNELSAMD 1698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492	23/53 (43%)
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	94/201 (47%)
arhgap21b	XP_001918968.3	PDZ_signaling	50..156	CDD:238492	49/151 (32%)
		PH_ARHGAP21-like	817..931	CDD:269955	32/189 (17%)
		PH	817..926	CDD:278594	31/176 (18%)
		RhoGAP_ARHGAP21	1031..1227	CDD:239860	94/201 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4310
eggNOG	1	0.900	-	-		E1_KOG4407
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	315	1.000	Inparanoid score	I2535
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24838
orthoMCL	1	0.900	-	-		OOG6_104725
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	1	1.000	-	-		X1550
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.750