DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and Arhgap21

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_001178622.1	Gene:	Arhgap21 / 307178	RGDID:	1311028	Length:	1952	Species:	Rattus norvegicus

Alignment Length:	2427	Identity:	517/2427 - (21%)
Similarity:	811/2427 - (33%)	Gaps:	822/2427 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PKLIVIRRRPNQGFGFTLRHFIAYPPEDDQASSSASGLVSGSATAATAASVSTNWPQEASSAAGS 116
            ||.::: :|.:|||||||||||.||||                     :::..::..|.:   |:
  Rat    52 PKTVML-KRTSQGFGFTLRHFIVYPPE---------------------SAIQFSYKDEEN---GN 91

  Fly   117 NSGSSSSVGVAGITGLEPTSPTSLPPYQVKAMETIFIKEVQANGPAHYANLQTGDRVLMVNNQPI 181
            ..|...:       .|||             |:|||:|:|:..|||..|.|.||||::.||.:.:
  Rat    92 RGGKQRN-------RLEP-------------MDTIFVKQVKEGGPAFEAGLCTGDRIIKVNGESV 136

  Fly   182 AGIAYSTIVSMIKQTPAVLTLHVVPKECDVLQM-----HYTSIAHTPESNRLTMSTHSPSLLANG 241
            .|..||.::::|:.:...|.|.|:||:.|:||:     ..|::|::.::          .|..||
  Rat   137 IGKTYSQVIALIQNSDTTLELSVMPKDEDILQVLQFTKDVTALAYSQDA----------YLKGNG 191

  Fly   242 SHKTTFPAAAAVAAPPHQHQQQQQQLISYPAVAAVTTST----PAGSPQSQSQSQSHSHP----- 297
            ::...   |..:..||.         :.||.:.|..::|    ....|.|....|..|.|
  Rat   192 AYSGN---ARDIPEPPP---------VCYPWLPATPSATAQPVEVSPPDSLLNKQQTSTPVLTQP 244

  Fly   298 ------NTHHAPSLHGGSRSGSITSTASGGI-TVLSQPFYPQQQ-------QQQQQQQQHRHPAL 348
                  .....||....::|.:.....|..: ||:    .|.::       :.......||...:
  Rat   245 GRAYRMEIQVPPSPTDVAKSNTAVCVCSESVRTVI----VPSEKVVDLLANRNSPSGPAHRTEEV 305

  Fly   349 TGGSSSIDFGDMAHGLRQHQQQQQHLYQQQQQHHQFMRANQPPNLTVLSASSATNTPTPTARQPK 413
            ..|.|     |.|.                                  :.::|..||.|:|  |.
  Rat   306 RYGVS-----DQAS----------------------------------AKAAARTTPPPSA--PT 329

  Fly   414 SATSHNQALYAVGAGPSSAAGSG----SGSLSGGSE----------------------NSDLMI- 451
            :..||..      .|..|...||    ||:.||.||                      ||...|
  Rat   330 ARLSHQT------IGSRSLEPSGILLKSGNYSGHSEGISSSRSQAVDSPPVSVNHYSANSHQHID 388

  Fly   452 --------------RLRESIKQKEEFLKSPVPASMSSASSINGNQAQSSSPAQQQHLQQHQQHFF 502
                          ||....:..:|.|.|...||.|:|   :.||...:..|.|...:.
  Rat   389 WKNYKTYKEYIDNRRLHIGCRTIQERLDSLRAASQSAA---DYNQVVPARTALQVRRRS------ 444

  Fly   503 PSH-TPPGGVQV---VVPPPRSRHQVMLKQQQQQQQQ---------HQQHHVLGYDMYHSGGK-- 552
            .|| ..|..:|:   .|...|....|::|...:...|         ...|....:| |..|..
  Rat   445 TSHDRVPQSIQIRQRSVSQERLEDSVLMKYCPRSASQGALTSPPVSFSNHRTRSWD-YIEGQSEA 508

  Fly   553 --LVQRSSTAPGSVCHQHQ--------QQQQHHLYHQQQHQQLQQTQHR-------QVMINNNAK 600
              .|...|..|.|...:.|        :|......|::..||......|       .|:.::|.:
  Rat   509 TATVNSESQTPDSNGERKQTYKWSGFTEQDDRRGIHERPRQQEMHKPFRGSNLTVAPVVNSDNRR 573

  Fly   601 YAKDLDYFETLQETGVTNKVFERKLV------SHMSKGFDPFKPLSI------NTSALESSASTS 653
                      |...|| ..|.:.|.:      .|.::.|.....:|:      :.|.|....|.|
  Rat   574 ----------LGGRGV-GPVSQFKKIPPDLRPPHSNRNFPTTSGMSLPRGIAQDRSPLVKVRSNS 627

  Fly   654 STSATTTVKKQSVLYESL----QQHPLAKYHQ----TQQ--------------QTTTTTTVDGQT 696
            ..:....|.|.|....||    .|.|:...||    :||              ||..:.::.|.:
  Rat   628 LKALPPPVPKPSFSQHSLASTKDQRPVNHLHQHGLLSQQTRGRPESTFPHLELQTDVSPSLPGTS 692

  Fly   697 SSRMELHKATLANATIDPVPVGSSKFVTLPDKPDKGSSVATLADIAESSAAAIVDSASGSGNVVR 761
            :.........|..:.:|           |...|..|...:..||:..|      |......:|:.
  Rat   693 AKTSPQLSENLGTSDLD-----------LHASPRNGDVDSQEADVQPS------DVPDNKESVIL 740

  Fly   762 RYKPLSSSSFDEGKPMRRISYLRATNN-ETDFNAEAAAGGD--------------AAATGASGPA 811
            |.||.......:  |:|..||:.|.|: ||..:.......|              |:.|...|.:
  Rat   741 REKPQPGRQTPQ--PLRHQSYILAVNDQETGSDPTCWLPNDARREVHIKRMEERKASCTSPPGDS 803

  Fly   812 SAS-------------------AASSAPGPTPSSAPAPAPAPAPLPISIPIPVAAVVEPQKT--- 854
            .||                   .||:....:.|..|:.|..|..|..|.|:....:...|::
  Rat   804 LASIPFIDEPTSPSIDHEVAHIPASAVISASTSQVPSIATVPPSLTTSAPLIRRQLSHDQESVGP 868

  Fly   855 KSLVEEHPDPT-----YDVIGGTGGGHEFIETPNGLEDVRLSAH---------------GSRRAS 899
            .||..:|...|     ||               .||:|.|..|.               .|:::|
  Rat   869 PSLDGQHTSKTERSKSYD---------------EGLDDYREDAKLSFKHVSSLKGIKIADSQKSS 918

  Fly   900 MSS----DMRSSIHIDAELNGKYVPNELEAFETEIEIKSSCINGKRM-SEYRSWRQVKLEIKGDL 959
            ..|    |..|.:..||...|..   :.....|:        .|||: ...|.|:|:.:.::|..
  Rat   919 EDSGSRKDSSSEVFSDAAKEGWL---QFRPLVTD--------KGKRVGGSIRPWKQMYVVLRGHS 972

  Fly   960 LRIYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPSGAHLASLGNELNLDEGHDK 1024
            |.:|..|                              |.|:.||.....::.  |...:|
  Rat   973 LYLYKDR------------------------------REQTTPSEEEQPISV--NACLID----- 1000

  Fly  1025 LLTSSGSSSANEPAANAASALTASTSSSTCSSGPYTEILFKTKSSNEMKRLFGLLQWKDSLNYDD 1089
                   .|.:|........||    :|.|      |.||:.:..::|......:|...:||.:|
  Rat  1001 -------ISYSETKRRNVFRLT----TSDC------ECLFQAEDRDDMLAWIKTIQESSNLNEED 1048

  Fly  1090 ----------------NEHQPQGKQLAEPQKTVASASYLDDVQGGASAADSSPLSSHSGGIADAS 1138
                            |....:.:||  |:....|.|....:.|    |.|.|
  Rat  1049 TGVTNRDLISRRIKEYNSLLSKTEQL--PKTPRQSLSIRQTLLG----AKSEP------------ 1095

  Fly  1139 GSHHVSALPAAAAIVAATSDSISPVMKARKSSSHKHIPDKDLGSPKSK-NWKDLLFRRGGSGSGG 1202
                            .|....||    ::.|..|.:...|...||.| .|     |||
  Rat  1096 ----------------KTQSPHSP----KEESERKLLSKDDTSPPKDKGTW-----RRG------ 1129

  Fly  1203 VSHHDLAS---------PSACAAKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVETKGLGVVG 1258
                 :.|         |:|     .|:.||.|..||.:..|.|:|.:|::|..:||.:||...|
  Rat  1130 -----IPSIVRKTFEKKPAA-----TGTFGVRLDDCPPAHTNRYIPLIVDICCKLVEERGLEYTG 1184

  Fly  1259 IYRIPGNKAAISELSELVN--TKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYIN 1321
            |||:|||.||||.:.|.:|  ..|...:    ||:|.|:||:|||||.|.|.||:.|.....|.:
  Rat  1185 IYRVPGNNAAISSMQEELNKGMADIDIQ----DDKWRDLNVISSLLKSFFRKLPEPLFTNDKYAD 1245

  Fly  1322 FIEADKKFG-LERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSII 1385
            ||||::|.. |:|:..|:.::..||.|.:||:|.|..||..|:.|.:.|:|||:||||:|||:::
  Rat  1246 FIEANRKEDPLDRLRTLKRLIHDLPEHHFETLKFLSAHLKTVAENSEKNKMEPRNLAIVFGPTLV 1310

  Fly  1386 RTPNDTLETAVKDMKHQCRIVELLVTQYDYFF--EGGSLPDIAEVSGGTAAVSAAQPQQQTQEDQ 1448
            ||..|.:...|..|..|.:|||.|:..:|:||  ||...|           ::|.|.:.......
  Rat  1311 RTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEEGAEEP-----------LTAVQEENTVDSQP 1364

  Fly  1449 TSMLLHNLSKIERITERETTRTSRFMPQLRRKTHGKRSAVNSDTYSGESVLVSGSSSNTTTTTTT 1513
            ...:.|.|:.|                       |:...:..|        ||.|:::.:|.:..
  Rat  1365 VPNIDHLLTNI-----------------------GRTGVLPGD--------VSDSATSDSTKSKG 1398

  Fly  1514 TTHTTSSTSSSNTITTTISTTTIQQRRAQRKAVQSICDQALILLLPTPVSSVSLPFQSLDYAKAS 1578
            :..:.....|...:.::|.....::|:..::..|             |.||.. ...|:.:.|.:
  Rat  1399 SWGSGKDQYSRELLVSSIFAAASRKRKKPKEKAQ-------------PSSSED-ELDSVFFKKEN 1449

  Fly  1579 ASASASASSTASTSSSSTLHSGGKASASSSSSSTTKFSSSSSSACSTTAVAISSSISATSSKLLS 1643
            ...|.|.....|...|.|  .|.|.....:..|.||..:.::          .......|.:...
  Rat  1450 MEPSHSEIKEESKRESET--PGRKQRVVVAKDSNTKKDTGTT----------KEEKKMPSDEPSP 1502

  Fly  1644 ANFKKRSTGGFLGSRSS--HQTRKASLDEKDSGQSSGSLGHSLGVGINLAKEQQRSSVDISILLT 1706
            .:..||:....|..|.:  .::.::.|.:|...:.:||...:|....:||:...:.|.......|
  Rat  1503 PHSSKRNRSPTLSCRLAMLKESPRSLLTQKPHCEETGSDSGTLSSQASLARSSTKKSTSPETRHT 1567

  Fly  1707 D--DDSSSRLSDTGSMSLTTITDTLDSKLRN--LRSGSESNDENGSPEFPKNRRHTLGQPLHMHS 1767
            :  .::.:..||..:.|.||...:|||...:  ::|.:||..:....|  ::...:.|:|:...|
  Rat  1568 EFLSNAGTITSDYSTTSSTTYLTSLDSSRLSPEVQSVAESKGDEADDE--RSELVSEGRPVETDS 1630

  Fly  1768 ENIPYADESPERLFHQFCNPLETAPLSLHLSRSCTATNTIGGDEKPSKQSGGVAPLPPSLLKAAH 1832
            |:             :|                                     |:.||.|.:..
  Rat  1631 ES-------------EF-------------------------------------PVFPSALTSGQ 1645

  Fly  1833 ---KLQHSATVPIH--QGSSTAPTSGAATPVGTPTGSGGAGAIPSRSSSSS------VTTLTKSI 1886
               |||..|.....  :||..:.|.|:.||           ::.||....|      ..||::..
  Rat  1646 FRGKLQEVARSSRRNSEGSEASCTEGSLTP-----------SLDSRRQQFSSHRLIECDTLSRKK 1699

  Fly  1887 QPRFSNYLSYERGNAAAGGAERVVGSAGGAASDDDSEGSTTSDPKEKLLLGERPSPSFFIERYNK 1951
            ..||.                          ||..|.|.|.:         |:.:|:.
  Rat  1700 SARFK--------------------------SDSGSPGDTRT---------EKETPAL------- 1722

  Fly  1952 KRRDHRLFRSASFNCRNYSTRHITAQTSGGVAAGVSGGVAGAVAVGVACCQALSTTGLTKDEKTD 2016
                                    |:....:..|.|.|             :|.|...::.||.:
  Rat  1723 ------------------------AKMFDVMKKGKSTG-------------SLLTPSRSESEKQE 1750

  Fly  2017 MNLTKKRQIQNK-------------------------QNRSIKRRHTVGGPHD---------YSA 2047
              .|.|.:|.::                         :.::||||||:||..|         :.|
  Rat  1751 --ATWKTKIADRLKLRPRAPADDMFGVGNQKPTAETAKRKNIKRRHTLGGHRDATEISVLSFWKA 1813

  Fly  2048 SNGGCSNHSHGHDLAAINYNHHNRHHQ----------QQLLKLGSATSGGGGSGAAAAETTTTTT 2102
            ........|   :|:|:|........|          :::....|..|...|....|...:...|
  Rat  1814 QEQSADKES---ELSAVNRLKPKCSAQDLSISDWLARERIRSSASDLSRSEGCEPQAESPSVLGT 1875

  Fly  2103 TTTTVLRRLGTGQAGAEASVALPASSSGSSSNNNNSPQS-DGSNG----NGGGVAGVASNAPPTG 2162
            .|:|   .........||..|...|:|.|....:..||| |..||    |....|..|:||.|..
  Rat  1876 PTST---HTPPPSQQPEARAAASTSASTSQPPLSTPPQSPDQINGDSFQNTSQNASSAANAHPHK 1937

  Fly  2163 VGVGGNNSSGSSSNSSSTSTTP 2184
            :         |.|.::.|.:.|
  Rat  1938 L---------SESPNTKTESPP 1950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492	21/53 (40%)
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	86/198 (43%)
Arhgap21	NP_001178622.1	PDZ_signaling	52..159	CDD:238492	47/151 (31%)
		PH_ARHGAP21-like	936..1045	CDD:269955	29/173 (17%)
		PH	937..1042	CDD:278594	29/169 (17%)
		RhoGAP_ARHGAP21	1147..1342	CDD:239860	86/198 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	143	1.000	Domainoid score	I4532
eggNOG	1	0.900	-	-		E1_KOG4407
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	268	1.000	Inparanoid score	I2948
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45831
orthoMCL	1	0.900	-	-		OOG6_104725
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1550
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.720