DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP19D and Arhgap12

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_001100827.2	Gene:	Arhgap12 / 307016	RGDID:	1310017	Length:	838	Species:	Rattus norvegicus

Alignment Length:	944	Identity:	205/944 - (21%)
Similarity:	330/944 - (34%)	Gaps:	275/944 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   592 QVMINNNAK-------YAKDLDYFETL----QETGVTNKVFERKLVSHMSKGFDPFKPLSINTSA 645
            ||.::.|:|       |.|::.....:    |.||:.|...:.....|:.:..:....:...:|.
  Rat    50 QVRLDENSKAFYVPAQYVKEVTRKALMPPVKQTTGLPNNSMKTTQSMHLQRSTENVNKMPELSSF 114

  Fly   646 LESSASTSSTSATTTVKKQSVLYESLQQHPLAKYH--QTQQQTTTTTTVDGQTSSRMELHKATLA 708
            .:.|:|...|.          |.....|:..:.|:  ||...:...|..:|:.:|.....|.:..
  Rat   115 GKPSSSVQGTG----------LIRDANQNFGSNYNSGQTLNLSLDLTHNNGKFNSDSHSPKVSSQ 169

  Fly   709 NAT----IDPVPVGSSKFVTLPDKPDKGSSVATLADIAESSAAAIVDSASGSGNVVRRYKPLSSS 769
            |.|    ..|.|    :|:.:  :....|...:.....|.|.....||.||.        .||||
  Rat   170 NRTRLFGHFPGP----EFLDI--EKTSFSQEQSCDSAGEGSERTHQDSESGD--------ELSSS 220

  Fly   770 SFDEGKPMRRISYLRATNNETDFNAEAAAGGDAAATGASGPASASAASSAPGPTPSSAPAPAPAP 834
            |.::         :|||.                      |.:.....|..............|.
  Rat   221 STEQ---------MRATT----------------------PPNQGRPDSPVYANLQELKISQSAL 254

  Fly   835 APLPISIPIPVAAVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGLEDVRLSAHGSRRAS 899
            .|||.|..|.|....|..|..|                  |..:.......|........:|..|
  Rat   255 PPLPGSPAIQVNGEWETHKDSS------------------GRCYYYNRTTQERTWKPPRWARDVS 301

  Fly   900 MSSDMRSSIHIDAELNGKYVPNELEAFETEIEIKSSCI---NGKRMSEYRSWRQVKLEIKGDLLR 961
            .|.|.:|             |.|.|...:|....|||.   :.:..|..|.|.:
  Rat   302 TSRDFQS-------------PGEQEPLSSEENYHSSCFSQSDSQCGSPPRGWSE----------- 342

  Fly   962 IYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPSGAHLASLGNELNLDEGHDKLL 1026
                          |||.|....:.....|:|:|..:.                   |:|.....
  Rat   343 --------------ELDERGHTLYTSDYTKEKWLKHVD-------------------DQGRQYYY 374

  Fly  1027 TSSGSSSANE-PAANAAS--------------------ALT---------------ASTSSSTC- 1054
            ::.||.|..| |..||:|                    .||               :.||:..|
  Rat   375 SADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKWRHSTIVLDSNDKDSPTSTKLCL 439

  Fly  1055 --SSGPYTEILFKTKSSNEMKRLFGLL------------------QWK----DSLNYDDNEHQPQ 1095
              :..|.|    .||..:..:..:|||                  .|.    .||.:...:....
  Rat   440 PENESPPT----STKHQDPGQEKYGLLNVTKITENGKKVRKNWLSSWAVLQGSSLLFTKTQGSST 500

  Fly  1096 ---GKQLAEPQKTVASASYLDDVQGGASAADSSPLSSHSGGIADASGSHHVSAL---PAAAAIVA 1154
               |...::|:.||       |::|.|....|.          |.|...:|..|   .....::.
  Rat   501 SWFGSNQSKPEFTV-------DLKGAAIEMASK----------DKSSKKNVFELKTRQGTELLIQ 548

  Fly  1155 ATSDS-ISPVMKARKSSSHKHIPDKDLG-------SP------KSKNWKDLLFRRGGSGSGGVSH 1205
            :.:|: |:...|...|:.:..:.:.|..       ||      |.|:.|:|...|...||...|.
  Rat   549 SDNDAVINDWFKVLSSTINNQVAEADEAAEEEAPDSPGVEKQDKEKDQKELKKLRSMKGSSMDSS 613

  Fly  1206 HDLAS-----------PSACAAKQIGSI-----GVPLRS-CPMSKVNAYVPHLVEVCTNIVETKG 1253
            ....:           |:..|.::.|.|     |..|.: |  .:.|..||..|::|...||..|
  Rat   614 EQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLC--QRENGTVPKFVKLCIEHVEEHG 676

  Fly  1254 LGVVGIYRIPGNKAAISELSELVNTKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASY 1318
            |.|.||||:.||.|.|.:|...|| .|.:.:  .:|.:|||::|::..||:|.|.||:.|...::
  Rat   677 LDVDGIYRVSGNLAVIQKLRFAVN-HDEKLD--LNDSKWEDIHVITGALKMFFRELPEPLFTFNH 738

  Fly  1319 YINFIEADKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPS 1383
            :.:|:.|.|:...:|:..:::::..||:...:||:.|.|||.||..|.:.|||..:::||:|||:
  Rat   739 FNDFVNAIKQEPRQRVTAVKDLIRQLPKPNQDTMQILFRHLKRVIENGEKNRMTYQSIAIVFGPT 803

  Fly  1384 IIRTPNDTLETAVKDMKHQCRIVELLVTQYDYFF 1417
            :::...:|...||..: :|.:||||::.:....|
  Rat   804 LLKPERETGNIAVHTV-YQNQIVELILLELSTVF 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	69/201 (34%)
Arhgap12	NP_001100827.2	SH3_ARHGAP12	13..72	CDD:213003	6/21 (29%)
		SH3-WW_linker	69..264	CDD:406914	45/249 (18%)
		WW	266..296	CDD:238122	5/47 (11%)
		PH_ARHGAP9-like	457..568	CDD:270053	22/127 (17%)
		RhoGAP_ARHGAP27_15_12_9	646..831	CDD:239868	68/190 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010