DRSC/TRiP Functional Genomics Resources

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Protein Alignment RhoGAP19D and Arhgap23

DIOPT Version :9

Sequence 1:NP_001285496.1 Gene:RhoGAP19D / 33048 FlyBaseID:FBgn0031118 Length:2206 Species:Drosophila melanogaster
Sequence 2:XP_006247499.1 Gene:Arhgap23 / 303501 RGDID:1309742 Length:1383 Species:Rattus norvegicus


Alignment Length:1850 Identity:382/1850 - (20%)
Similarity:600/1850 - (32%) Gaps:622/1850 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   148 METIFIKEVQANGPAHYANLQTGDRVLMVNNQPIAGIAYSTIVSMIKQTPAVLTLHVVPKECDVL 212
            |:|||:|.|:..||||.|.|:||||::.||.:.:.|..||.::.:|:.:...|.|.::||:.|:|
  Rat     1 MDTIFVKNVKEGGPAHRAGLRTGDRLVKVNGESVIGKTYSQVIGLIQNSDDTLELSIMPKDEDIL 65

  Fly   213 QMHYTSIAH-------------TPESNRL--TMSTHSPSLLANGSHKTTFPAAAAVAAPPHQHQQ 262
            |:.|:..|:             .||...|  ...|::|        .|..||.|.:...|     
  Rat    66 QLAYSQDAYLKGNEPYSGEARSIPEPPPLCYPRKTYAP--------PTRAPAWATMVPEP----- 117

  Fly   263 QQQQLISYPAVAAVTTS--TPA--GSPQSQSQSQSHSH------------PNTHHAPSLHGGSRS 311
                      ::|:.|.  :||  ..|.|:..|.:.:|            |:....|.|...||:
  Rat   118 ----------ISALPTDPRSPAAWSDPGSRVTSATRAHLDNSSLGMSQPRPSPGAFPHLPSESRT 172

  Fly   312 GSITSTASGGITVLSQPFYPQQ-------QQQQQQQQQHRHPALTGGSSSIDFGDMAHGLRQH-- 367
            .  .:....|..||......||       .|..::..:.|.||:...:.|.. .|....:..|  
  Rat   173 P--RAFLESGSRVLPSRLECQQALSHWLSNQIPRRAGERRCPAMPPRARSAS-QDRLEDVTTHHP 234

  Fly   368 ---QQQQQHLYQQQQQHHQFMRANQPPNLTVLSA----------------------SSATNTPTP 407
               ...|..|.|..|:.....|::...:....||                      |||..:..|
  Rat   235 WPCSTSQDALSQLGQEGWHRARSDDYLSRATRSAEALGPGALVSPRLERCGWASQRSSARTSACP 299

  Fly   408 TARQPKSATSHNQALYAVGAGPSSAAGSGSGSLSG----GSENSDLMIRLRESIKQKEEFLKSP- 467
            :...|               ||.:...||...|..    |..:.....:.|..:.....|..|| 
  Rat   300 SRDLP---------------GPQAPPASGLQGLDDIGYIGYRSYSPSFQRRTGLLHALSFRDSPF 349

  Fly   468 --VPASMSSASSINGNQAQSSSPAQQQHLQQHQQHFFPSHTPPGGVQVVVPPPRSRHQVMLKQQQ 530
              :| :.|.|.|                         |:..||   :...||..:|.....:..:
  Rat   350 GGLP-TFSLAQS-------------------------PASFPP---EASEPPRVARPDPSTRALE 385

  Fly   531 QQQQQHQQHHVLGYDMYHSGGKLVQRSSTAPGSVCHQHQQQQQHHLYHQQQHQQLQQTQHRQVMI 595
            ...:.|:...||             |.....|                    :::|.|..|||  
  Rat   386 PPAEDHRDEVVL-------------RQKPPTG--------------------RKVQLTPARQV-- 415

  Fly   596 NNNAKYAKDLDYFETLQETGVTNKVFERKLVSHMSKGFDPFKPLSINTSALESSASTSSTSATTT 660
                                  |..|..:.:...::|..|.:.::                    
  Rat   416 ----------------------NLGFGDESLEPEARGERPGRKVA-------------------- 438

  Fly   661 VKKQSVLYESLQQHPLAKYHQTQQQTTTTTTVDGQTSSRMELHKATLANATIDPVPVGSSKFVTL 725
                          |||   .|:....:...:|..||..::|                .:|.|  
  Rat   439 --------------PLA---TTEDSLASIPFIDEPTSPSIDL----------------QAKHV-- 468

  Fly   726 PDKPDKGSSVATLADIAESSAAAIVDSASGSGNVV--------------RRYKPLSSSSFDEGKP 776
                               .|:|:|.||..|..|:              |.|....||.    |.
  Rat   469 -------------------PASAVVSSAMNSAPVLGTSPSSPTFTFALSRHYSQDCSSI----KA 510

  Fly   777 MRRISYLRATNNETDFNAEAAAGGDAAATGASGPASASAASSAPGPTPSSAPAPAPAPAPLPISI 841
            .||.|||.|...|...:.:     |...|...   ........|...||                
  Rat   511 GRRSSYLLAITTERSKSCD-----DGLNTFRD---EGRVLRRLPNRVPS---------------- 551

  Fly   842 PIPVAAVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGLEDVRLSAHGSRRASMSSDMRS 906
                        .:.|.....|.:.|    :.|..|..|.|            |:|.| :||:..
  Rat   552 ------------LRMLRSFFTDGSLD----SWGTSEDAEAP------------SKRHS-TSDLSD 587

  Fly   907 SIHIDAELNGKYVPNELEAFETEIEIKSSCINGKRM-SEYRSWRQVKLEIKGDLLRIYSGRHAKS 970
            :...|....|       ..:..:|..|    .||:. ...|.|:           |:|:...|:|
  Rat   588 ATFSDIRREG-------WLYYKQILTK----KGKKAGGGLRQWK-----------RVYAVLRARS 630

  Fly   971 EHNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPSGAHLASLGNELNLDEGHDKLLTSSGSSSAN 1035
                            .|:.|::      .:|.|:.|..|:.|               :|...| 
  Rat   631 ----------------LSLSKER------REPGPAAAGAAAAG---------------AGEDEA- 657

  Fly  1036 EPAANAASALTASTSSS------TCSSGPYTEILFKTKSSNEMKRLFGLLQWKDSLNYDDN-EHQ 1093
            .|....:..:..|.|.:      ..::..:.|.||:.:..::|      |.|..::..:.. |.:
  Rat   658 APVCIGSCLVDISYSETKRRHVFRLTTADFCEYLFQAEDRDDM------LGWIRAIRENSRAEGE 716

  Fly  1094 PQG--------KQLAEPQKTVASASYLDDVQGGASAADSSPLSSHS-GGI-ADASGSHHVSALPA 1148
            ..|        |:|.:.:|...|:         ...|||||..|.. ||: ::......|..|..
  Rat   717 DPGCANQALISKKLNDYRKVSHSS---------GPKADSSPKGSRGLGGLKSEFLKQTAVRGLRT 772

  Fly  1149 AAAIVAATSDSISPVMKARKSSSHKHIPDKDLGSPKSKNWKDLLFRRGGSGSGGVSHHDLASPSA 1213
            ......:..||::                    :||:. |          |...:..:..|:|.|
  Rat   773 QDQPAGSKEDSVT--------------------TPKTP-W----------GINIIKKNKKAAPRA 806

  Fly  1214 CAAKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSELVN- 1277
                    .|:.|..|..:..|..||.:|..|..|||.:||...||||:|||.|.:|.|.|.:| 
  Rat   807 --------FGIRLEDCQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNR 863

  Fly  1278 -TKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYINFIEADK-KFGLERIVLLREI 1340
             ..|...:    |:||:|:||:|||||.|.|.||:.|.....|.:||||:: :...||:..||::
  Rat   864 GPSDINLQ----DERWQDLNVISSLLKAFFRKLPEPLFTDDKYNDFIEANRIEDSRERMKTLRKL 924

  Fly  1341 VESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRI 1405
            :..||.|.|||:|.|:.||..::.:.:.|:|||:|||::|||:::||..|.:...|..|..:.:|
  Rat   925 IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKI 989

  Fly  1406 VELLVTQYDYFFEGGSLPDIAEVSGGTAAVSAAQPQQQTQEDQTSMLLHNLSKIERITERETTRT 1470
            ||.|:...|:||...      |..|....|...:||             ::..||.:        
  Rat   990 VETLIQHSDWFFSDD------EDKGERTPVDDKEPQ-------------SVPNIEYL-------- 1027

  Fly  1471 SRFMPQLRRKTHGKRSAVNSDTYSGESVLVSGSSSNTTTTTTTTTHTTSSTSSSNTITTTISTTT 1535
               :|.:      .|:...||..|.:|...|.:.|..:.......:.....:.|       ..:.
  Rat  1028 ---LPNI------GRTVPPSDPGSADSTTCSSAKSKGSWVPKKEPYAREMLAIS-------FISA 1076

  Fly  1536 IQQRRAQRKAVQSI-----------CDQALILLLPTPVSSVSLPFQSLDYAKASASAS------- 1582
            :.::|.:|:..:.:           ..:|.:.....|..  .||..|.:.|....|.|       
  Rat  1077 VNRKRKKRREARGLGSSTDDDSEQEAHKAAVGTQEPPEG--QLPGPSAEEAPGRLSPSTAPDERP 1139

  Fly  1583 -------ASASSTASTSSSSTLHSGGKASASSSSSSTTKFSSSSSSACSTTAVAISSSISATSSK 1640
                   .|..||.||...|.....|...|.:...:..:.|..|.....|...|           
  Rat  1140 AADTRSIVSGYSTLSTMDRSVCSGTGGRRAGAGDEADDERSELSHVETDTEGGA----------- 1193

  Fly  1641 LLSANFKKRSTGGFLGSR---SSHQ--------TRKASLDEKDSGQSSGSLGHSLGVGINLAKEQ 1694
                     ..||.|..|   |||.        .|:.|....|:....|.  ..||...:.::|.
  Rat  1194 ---------GPGGRLARRPSFSSHHLMPCDTLARRRLSRSRADAEGPRGP--EPLGSASSSSQES 1247

  Fly  1695 QRSSVDISILLTDDDSSSRLSDTGSMSLT---TITDTLDSKLRNLRSGSESNDENGSPEFPKNRR 1756
            .|......:|      .||.|...::.|.   |..|.|..:||.             |..|:.||
  Rat  1248 LRPPAAAPVL------GSRPSRVEALRLRLRGTADDMLAVRLRR-------------PLSPETRR 1293

  Fly  1757 HTLGQPLHMHSENIPYADESPERLFHQF-----CNPLETAPLSLHLSRSCTATNTIGGDEKPSKQ 1816
            .......|......|..|.:    |:::     ..|.|:|.:..|.....:..:::   |....:
  Rat  1294 RRSSWRRHTVVVQSPLTDLN----FNEWKELDGGGPPESAGVRPHSDNKDSGLSSL---ESTKAR 1351

  Fly  1817 SGGVAPLPPSLLKAAHKL--QHSATVPIHQ 1844
            :...|.||...|.|...|  :.||...:||
  Rat  1352 ASSAASLPSGDLGALQGLPARRSAAARLHQ 1381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP19DNP_001285496.1 PDZ_signaling <151..205 CDD:238492 22/53 (42%)
RhoGAP_ARHGAP21 1221..1417 CDD:239860 81/198 (41%)
Arhgap23XP_006247499.1 PDZ_signaling <4..57 CDD:238492 22/52 (42%)
PH 593..712 CDD:278594 29/184 (16%)
PH_ARHGAP21-like 594..714 CDD:269955 29/185 (16%)
RhoGAP_ARHGAP21 806..1001 CDD:239860 82/206 (40%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166336043
Domainoid 1 1.000 143 1.000 Domainoid score I4532
eggNOG 1 0.900 - - E1_KOG4407
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 268 1.000 Inparanoid score I2948
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm45831
orthoMCL 1 0.900 - - OOG6_104725
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1550
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.690

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