DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RhoGAP19D and rga7

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_595866.1	Gene:	rga7 / 2540635	PomBaseID:	SPBC23G7.08c	Length:	695	Species:	Schizosaccharomyces pombe

Alignment Length:	831	Identity:	177/831 - (21%)
Similarity:	293/831 - (35%)	Gaps:	280/831 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   662 KKQSVLYE----SLQQHPLAK-YHQT-QQQTTTTTTVDGQTSSRMELHKATLANATIDPVPVGSS 720
            ||:|:|.|    :||:  ||| |.:| |.:..:..:......:.||:|: .|||.::
pombe    67 KKRSILEEESGKNLQK--LAKSYLETFQSKHHSPQSFSASVITSMEIHE-QLANHSL-------- 120

  Fly   721 KFVTLPDKPDKGSSVATLADIAESSAAAIVD---SASGSGNVVRRYKPLSSSSFDEGKPMRRISY 782
                            ||.....:.:..:::   :|......::.|.....:::.|.......|.
pombe   121 ----------------TLQKTLSAFSDQVIEFHKNAERKRKSIKEYAKKQENAYLEAVMQMDKSK 169

  Fly   783 LRATNNETDFNAEAAAGGDAAATGASGPASASAASSAPGPTPSSAPAPAPAPAPLPISIPIPVAA 847
            .|....||::|...    |...||.|...                                  ..
pombe   170 SRFKGAETEYNRAL----DNKNTGDSQKK----------------------------------VG 196

  Fly   848 VVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGLED-VRLSAHGSRRASMSSDMRSSIHID 911
            ..:|:....|.:                         ||| .||.|..:     .|||.|.|.
pombe   197 FFKPKSNAQLTK-------------------------LEDEARLKAENA-----ESDMHSKIE-- 229

  Fly   912 AELNGKYVPNELEAFETEIEIKSSCINGKRMSEYRSWRQVKLEIKGDLLRIYSGRHAKSEHNVIE 976
               |.:.|..:|           .||:  |.:..:.:..::.||:..|:..|
pombe   230 ---NAQNVQKQL-----------LCIH--RPNYIKQFFSLQREIESSLIANY------------- 265

  Fly   977 LDIRNFKFFDESMDKKKYLIRMQSKPSPSGAHL-------------------ASLGNELN---LD 1019
              :|..|..:.:.......||.| ||:|:...|                   ||:.:|.|   .|
pombe   266 --LRYTKLCESNTLLNGLTIRPQ-KPTPTNCGLQHALDNINANTDFVQYVLHASIKHEDNKNPTD 327

  Fly  1020 EGHDKLLT-----SSGSSSA-NEPAANAASALTASTSSSTCSSGPYTEIL---------FKTKSS 1069
            ....|::.     .:|||:. ..|..|....:||:..|...::.|.....         |...|:
pombe   328 ASKTKIIQPPSSYGTGSSAGKTNPPVNPTIKVTAAIPSPLQNTNPAPSTFPNPSVASPAFPNSST 392

  Fly  1070 NEMKRLFGLLQWKDSLNYDDNEHQPQGKQLAEPQKTVASASYL---------DDVQGGASAAD-- 1123
                                          :.|....||||.|         :|..|.:|::.
pombe   393 ------------------------------SNPSTAPASASPLASTLKPSTANDTNGSSSSSSSN 427

  Fly  1124 ---SSPLSSHSGG---IADASGSHHVSALPAAAAIVAATSDSISP----VMKARKSSSHKHIPDK 1178
               ||||:|::..   :|..|....:..||........||..::|    :...|.:|..:  |..
pombe   428 PRTSSPLASNAENKPPVAQQSPPVLLPTLPPIQTTTIQTSREVAPPPSSINSNRAASPFR--PTS 490

  Fly  1179 DLGSPKSKNWKDLLFRRGGSGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSKVNAYVPHLVE 1243
            ....|.|.. |.|||                             |..|.:. :.:.::.:|::|.
pombe   491 VSPQPSSPT-KSLLF-----------------------------GARLDAI-ILREHSNIPNIVM 524

  Fly  1244 VCTNIVETKGLGVVGIYRIPGNKAAISEL-SELVNTKDFQFESCASDDRWEDVNVVSSLLKLFIR 1307
            .||:.||..||.:.||||:|.:.|.::.| |:..|....|..:  .:|...||:.|:.|||:|.|
pombe   525 QCTSQVENFGLNLQGIYRVPSSSARVNMLRSQFENNPLLQLHT--PEDYENDVHAVADLLKIFFR 587

  Fly  1308 SLPDALMPASYYINFIEA----DKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDV 1368
            .|.:.|:|.::..:||:|    |:.   .|...:...:..||...|.|::||..||.::..|.||
pombe   588 ELREPLIPDNHQRDFIDAGNVEDES---RRRDAVHRAINDLPDANYSTIRHLTIHLAKIKENSDV 649

  Fly  1369 NRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRIVELLV----TQYDY 1415
            |:|...|||||:||:||:      :..:.::....|.:|:|:    |.:||
pombe   650 NKMSTNNLAIIWGPTIIK------QATIPEISSFSRTIEILIDYCFTIFDY 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	65/204 (32%)
rga7	NP_595866.1	F-BAR_Rgd1	39..277	CDD:153336	58/337 (17%)
		PRR18	335..>406	CDD:292299	16/100 (16%)
		RhoGAP_fRGD1	504..692	CDD:239863	64/228 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	96	1.000	Domainoid score	I1919
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001164
OrthoInspector	1	1.000	-	-		oto101607
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23176
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.130