Protein Alignment RhoGAP19D and rga4

DIOPT Version :10

• Sequence 1: NP_001285496.1
• Gene: RhoGAP19D / 33048
• FlyBaseID: FBgn0031118
• Length: 2206
• Species: Drosophila melanogaster
• Sequence 2: NP_595756.1
• Gene: rga4 / 2540593
• PomBaseID: SPBC28E12.03
• Length: 933
• Species: Schizosaccharomyces pombe
• Alignment Length: 1036
• Identity: 219/1036 - (21%)
• Similarity: 354/1036 - (34%)
• Gaps: 320/1036 - (30%)

  Fly   458 KQKEEFLKSPVPASMSSAS------SINGNQAQSSSPAQQQHLQQHQQHFFPSHTP----PGGVQ 512
            ||.||..|    |.|.|||      :|......:|...|.|..|  ..||..|.:|    .|.:|
pombe   132 KQDEENQK----AVMESASGFIPLRNIAQTAENTSLTGQNQGFQ--NPHFIASDSPSSVLSGRMQ 190

  Fly   513 VVVPPPRSRHQVMLKQQQQQQQQHQQHHVLGYDMYHSGGKLVQRSSTAPGSVCHQHQQQQQHHLY 577
            ....|..|     |:.|.:.|..       ||:              .||.:
pombe   191 NTSSPTNS-----LRPQLKVQTN-------GYE--------------TPGDI------------- 216

  Fly   578 HQQQHQQLQQTQHRQVMINNNAKYAKDLDYFETLQETGVTNKVFERKLVSHMSKGFDPFKPLSIN 642
                               |:||..||:.....|:    ....|.:...|.::.| ..|:  |.|
pombe   217 -------------------NSAKSYKDIQKDFLLK----PKNSFVKTSPSPLANG-PSFR--SAN 255

  Fly   643 TSALESSASTSSTSA----TTTVKKQSVLYESLQQHPLAKYHQTQQQTTTTTTVDGQTSSRMELH 703
            .|..:|..|..|.|:    ..:.::.||:..:..|.|:| ||...|..|...|:.       :|.
pombe   256 ASPFDSCDSFHSGSSIPIEPVSSRQSSVVNNNSVQQPVA-YHAFVQSPTENGTLP-------QLP 312

  Fly   704 KATLANATIDPVPVGSS-----KFVTLPDKPDKGSSVA------------TLADIAESSAAAIVD 751
            |   ..:.::|.|:..|     |.|:....|.|...|:            .|.|:.......:..
pombe   313 K---NESVVNPPPLRRSSTMNYKSVSTTTSPSKYGYVSGRIALSPIHLRGALRDVTNKCNLKVPR 374

  Fly   752 SASGSGNVVRRYKPLSSSSFDEGKPMRRISYLRATNNETDFNAEAAAGGDAAATGASGPASASAA 816
            :.:...|:...|  ::....||.....|........|:.|                     ....
pombe   375 NRNSLSNLDEYY--VNGLESDETPTKARFPRYPTVFNKLD---------------------DKRL 416

  Fly   817 SSAPGP-----TPSSAPAPAPAPAPLPISIPIPVAAVVEPQKTK-SLVEEHPDPTYDVIGGTGGG 875
            ||.|..     |.||....:|....|.:| .:.:....||:..: |||......|.:|...|.
pombe   417 SSEPNGLKKRLTNSSNYEASPRAKSLNLS-QVSLHQACEPEYNRSSLVRASDVFTSNVFDATE-- 478

  Fly   876 HEFIETPNGLEDVRLSAHGSRRASMSSDMRSSIHIDAELNGKYVPNELEAFETEIEIKSSCINGK 940
                |:.|.|. :|:|...:...::..:..|.    |.:..:..|...|||:.|:....:    .
pombe   479 ----ESANELA-IRISELQAEVGTLLLEATSL----ASIIEQQTPVSPEAFKQELVADLN----Y 530

  Fly   941 RMSEYRSWRQVKLEIKGDLLRIYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPS 1005
            |:...|  :..:.|:...|||    |.|.|. .|.:|.    ..:...|::..||       :..
pombe   531 RLDYLR--KSFQPELSTLLLR----RDALST-TVSKLQ----NAYSTVMEETAYL-------NVK 577

  Fly  1006 GAHLASLGNELN------LDEGHDKLLTSSGSSSANEPAANAASALTASTSSSTCS--------- 1055
            ...|.||.|:|.      .::.|.|..:||.....|:..:|.    |.||.|...|
pombe   578 NTELVSLNNQLERELAYLREQQHKKRTSSSFGIFNNDKKSNR----TISTPSPRESFSRLQMVAS 638

  Fly  1056 -------------SGPYTEILFKTKSSNEMKRLFG-LLQWKDSLNYDDNEHQPQGKQLAEPQKTV 1106
                         ||.|.    |..|..::|:.|. ...||     .|:.|......::|  :.:
pombe   639 SLGFRPKDNKDKESGGYN----KRNSKIDLKKSFSKRFHWK-----RDSPHMSSTPSISE--EHL 692

  Fly  1107 ASASYLDDVQGGASAADSSPLSSH---SGGIADASGSHHVSALPAAAAIVAATSDSISPVMKARK 1168
            ||....|.|          |...|   .|..::...:|:...:          |.:|....:::|
pombe   693 ASEEQEDFV----------PAVGHCKLCGKYSNELRAHYQDCV----------SSTIDRQYQSKK 737

  Fly  1169 SSSHKHIPDKDLGSPKSKNWKDLLFRRGGSGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSK 1233
            |.|    |...| :|...:...|...|
pombe   738 SES----PVWAL-NPDDFDQNRLTLLR-------------------------------------- 759

  Fly  1234 VNAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSELVNTKDFQFESCASDDRWEDVNVV 1298
                ||.|:..|.|.:|:.|:...|:||..|..:.:.::..|:..:|...      |..||::.|
pombe   760 ----VPTLIVSCINFIESYGMDFEGLYRKSGATSQMKKIVALLRNEDTVL------DPSEDISAV 814

  Fly  1299 SSLLKLFIRSLPDALMPASYYINFIEA-------DKKFGLERIVLLREIVESLPRHPYETMKHLI 1356
            :|:.|.::|:||:.::....|..||.|       ||   |:..::   :::|||....|.::.:|
pombe   815 TSVFKQYLRNLPNPIITYDQYFPFITAANCASFQDK---LDGFIM---VIKSLPPAHAEILQLII 873

  Fly  1357 RHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQYDYFF 1417
            |||.||:.....|||..||||::|.|::||.|:::.:           ::::.|..|...|
pombe   874 RHLARVAAYSHANRMTSKNLAVVFSPTLIRDPDNSRD-----------VIDMTVKNYSLAF 923

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_canonical	52..204	CDD:483948
		RhoGAP_ARHGAP21	1221..1417	CDD:239860	53/202 (26%)
rga4	NP_595756.1	LIM	24..78	CDD:259829
		CENP-H	543..>606	CDD:461756	18/78 (23%)
		RhoGAP	759..928	CDD:214618	55/230 (24%)