DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and rga4

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_595756.1	Gene:	rga4 / 2540593	PomBaseID:	SPBC28E12.03	Length:	933	Species:	Schizosaccharomyces pombe

Alignment Length:	1036	Identity:	219/1036 - (21%)
Similarity:	354/1036 - (34%)	Gaps:	320/1036 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   458 KQKEEFLKSPVPASMSSAS------SINGNQAQSSSPAQQQHLQQHQQHFFPSHTP----PGGVQ 512
            ||.||..|    |.|.|||      :|......:|...|.|..|  ..||..|.:|    .|.:|
pombe   132 KQDEENQK----AVMESASGFIPLRNIAQTAENTSLTGQNQGFQ--NPHFIASDSPSSVLSGRMQ 190

  Fly   513 VVVPPPRSRHQVMLKQQQQQQQQHQQHHVLGYDMYHSGGKLVQRSSTAPGSVCHQHQQQQQHHLY 577
            ....|..|     |:.|.:.|..       ||:              .||.:
pombe   191 NTSSPTNS-----LRPQLKVQTN-------GYE--------------TPGDI------------- 216

  Fly   578 HQQQHQQLQQTQHRQVMINNNAKYAKDLDYFETLQETGVTNKVFERKLVSHMSKGFDPFKPLSIN 642
                               |:||..||:.....|:    ....|.:...|.::.| ..|:  |.|
pombe   217 -------------------NSAKSYKDIQKDFLLK----PKNSFVKTSPSPLANG-PSFR--SAN 255

  Fly   643 TSALESSASTSSTSA----TTTVKKQSVLYESLQQHPLAKYHQTQQQTTTTTTVDGQTSSRMELH 703
            .|..:|..|..|.|:    ..:.::.||:..:..|.|:| ||...|..|...|:.       :|.
pombe   256 ASPFDSCDSFHSGSSIPIEPVSSRQSSVVNNNSVQQPVA-YHAFVQSPTENGTLP-------QLP 312

  Fly   704 KATLANATIDPVPVGSS-----KFVTLPDKPDKGSSVA------------TLADIAESSAAAIVD 751
            |   ..:.::|.|:..|     |.|:....|.|...|:            .|.|:.......:..
pombe   313 K---NESVVNPPPLRRSSTMNYKSVSTTTSPSKYGYVSGRIALSPIHLRGALRDVTNKCNLKVPR 374

  Fly   752 SASGSGNVVRRYKPLSSSSFDEGKPMRRISYLRATNNETDFNAEAAAGGDAAATGASGPASASAA 816
            :.:...|:...|  ::....||.....|........|:.|                     ....
pombe   375 NRNSLSNLDEYY--VNGLESDETPTKARFPRYPTVFNKLD---------------------DKRL 416

  Fly   817 SSAPGP-----TPSSAPAPAPAPAPLPISIPIPVAAVVEPQKTK-SLVEEHPDPTYDVIGGTGGG 875
            ||.|..     |.||....:|....|.:| .:.:....||:..: |||......|.:|...|.
pombe   417 SSEPNGLKKRLTNSSNYEASPRAKSLNLS-QVSLHQACEPEYNRSSLVRASDVFTSNVFDATE-- 478

  Fly   876 HEFIETPNGLEDVRLSAHGSRRASMSSDMRSSIHIDAELNGKYVPNELEAFETEIEIKSSCINGK 940
                |:.|.|. :|:|...:...::..:..|.    |.:..:..|...|||:.|:....:    .
pombe   479 ----ESANELA-IRISELQAEVGTLLLEATSL----ASIIEQQTPVSPEAFKQELVADLN----Y 530

  Fly   941 RMSEYRSWRQVKLEIKGDLLRIYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPS 1005
            |:...|  :..:.|:...|||    |.|.|. .|.:|.    ..:...|::..||       :..
pombe   531 RLDYLR--KSFQPELSTLLLR----RDALST-TVSKLQ----NAYSTVMEETAYL-------NVK 577

  Fly  1006 GAHLASLGNELN------LDEGHDKLLTSSGSSSANEPAANAASALTASTSSSTCS--------- 1055
            ...|.||.|:|.      .::.|.|..:||.....|:..:|.    |.||.|...|
pombe   578 NTELVSLNNQLERELAYLREQQHKKRTSSSFGIFNNDKKSNR----TISTPSPRESFSRLQMVAS 638

  Fly  1056 -------------SGPYTEILFKTKSSNEMKRLFG-LLQWKDSLNYDDNEHQPQGKQLAEPQKTV 1106
                         ||.|.    |..|..::|:.|. ...||     .|:.|......::|  :.:
pombe   639 SLGFRPKDNKDKESGGYN----KRNSKIDLKKSFSKRFHWK-----RDSPHMSSTPSISE--EHL 692

  Fly  1107 ASASYLDDVQGGASAADSSPLSSH---SGGIADASGSHHVSALPAAAAIVAATSDSISPVMKARK 1168
            ||....|.|          |...|   .|..::...:|:...:          |.:|....:::|
pombe   693 ASEEQEDFV----------PAVGHCKLCGKYSNELRAHYQDCV----------SSTIDRQYQSKK 737

  Fly  1169 SSSHKHIPDKDLGSPKSKNWKDLLFRRGGSGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSK 1233
            |.|    |...| :|...:...|...|
pombe   738 SES----PVWAL-NPDDFDQNRLTLLR-------------------------------------- 759

  Fly  1234 VNAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSELVNTKDFQFESCASDDRWEDVNVV 1298
                ||.|:..|.|.:|:.|:...|:||..|..:.:.::..|:..:|...      |..||::.|
pombe   760 ----VPTLIVSCINFIESYGMDFEGLYRKSGATSQMKKIVALLRNEDTVL------DPSEDISAV 814

  Fly  1299 SSLLKLFIRSLPDALMPASYYINFIEA-------DKKFGLERIVLLREIVESLPRHPYETMKHLI 1356
            :|:.|.::|:||:.::....|..||.|       ||   |:..::   :::|||....|.::.:|
pombe   815 TSVFKQYLRNLPNPIITYDQYFPFITAANCASFQDK---LDGFIM---VIKSLPPAHAEILQLII 873

  Fly  1357 RHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQYDYFF 1417
            |||.||:.....|||..||||::|.|::||.|:::.:           ::::.|..|...|
pombe   874 RHLARVAAYSHANRMTSKNLAVVFSPTLIRDPDNSRD-----------VIDMTVKNYSLAF 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	53/202 (26%)
rga4	NP_595756.1	LIM	24..78	CDD:259829
rga4	NP_595756.1	RhoGAP	759..928	CDD:214618	55/230 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001164
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000