DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and Arhgap33

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_001276611.1	Gene:	Arhgap33 / 233071	MGIID:	2673998	Length:	1305	Species:	Mus musculus

Alignment Length:	1170	Identity:	243/1170 - (20%)
Similarity:	401/1170 - (34%)	Gaps:	350/1170 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   999 QSKP-SPSGAHLASLGNEL------NLD---EGH-DKLLTSSGSSSANEPAANAASALTASTSSS 1052
            ||.| .|.||..|..|..|      :||   ||. ..:.|:.|..:..:|....::........:
Mouse     7 QSDPILPWGASWAGRGQTLRARSTDSLDGPGEGSVQPVPTTGGPGTKGKPGKRLSAPRGPFPRLA 71

  Fly  1053 TCSSGPYTEILF------------KTKSSNEMKRLFGL------LQWKDSLNYDD----NEH--- 1092
            .|:...|..:.|            ....|.|.:.:||:      ..|....:|||    :.|
Mouse    72 DCAHFHYENVDFGHIQLLLSPEREGPSLSGENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHR 136

  Fly  1093 ---------------QPQGKQLAEPQKTVASASYLDDVQGGASAADSS----------PLSSHSG 1132
                           .|:|.:.|: ........||:.:.|   ..||:          .|.:|..
Mouse   137 CIFDRRFSCLPELPPPPEGTRAAQ-MLVPLLLQYLETLSG---LVDSNLNCGPVLTWMELDNHGR 197

  Fly  1133 G-IADASGSHHVSALPAAAAIVAATSDSISPVMKARKSSSHKHIPDK------------DLGSPK 1184
            . :.....|.::.|:.||..:...|:.:                ||:            |:...:
Mouse   198 RLLLSEEASLNIPAVAAAHVVKRYTAQA----------------PDELSFEVGDIVSVIDMPPTE 246

  Fly  1185 SKNW----------------KDLLFRRGGSG--------------SGGVSHHDLASPSACAAKQI 1219
            .::|                .:|...|.|.|              ..|:|....|.|.. ..|..
Mouse   247 DRSWWRGKRGFQVGFFPSECVELFTERPGPGLKADADSPLCGIPAPQGISSLTSAVPRP-RGKLA 310

  Fly  1220 GSIGVPLRSCP-----------------------MSKVNAYVPHLVEVCTNIVETKGLGVVGIYR 1261
            |.:...:||.|                       :|.....||.::..|:..:|..|: |.||||
Mouse   311 GLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGV-VDGIYR 374

  Fly  1262 IPGNKAAISELSELVNTKDFQFES-----CASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYIN 1321
            :.|..:.|..|..       :|:|     .:.....:|::.||||.||:.|.||:.|:....|..
Mouse   375 LSGVSSNIQRLRH-------EFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGK 432

  Fly  1322 FIEADKKFG-LERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSII 1385
            |.||....| .||:|.:.::::.||...|.|:::|:|||.|::.:.....|..:||||::.|:::
Mouse   433 FSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLL 497

  Fly  1386 RTPNDTLET-------AVKDMKHQCRIVELLVTQY-----DYFFEGGSLP----------DIAEV 1428
            |:..  ||:       |.::::.|..:||.|:|..     |.|...|..|          .:|..
Mouse   498 RSME--LESVGLGGAAAFREVRVQSVVVEFLLTHVEVLFSDTFTSAGLDPAGRCLLPRPKSLAGS 560

  Fly  1429 SGGTAAVSAAQPQQQTQEDQTSMLLHNLSKIERITERETTRT--------SRFMPQLRRKTHGKR 1485
            |..|..::..:.|.:||           .::...||..|.:|        .|...:.:||..|..
Mouse   561 SPSTRLLTLEEAQARTQ-----------GRLGTPTEPTTPKTPASPVERRKRERAEKQRKPGGSS 614

  Fly  1486 SAVNSDTYSGESV----------------LVSGSSSNTTTTTTTTTHTTSSTSSSNTITTTISTT 1534
            .........|.|:                ..|||..:|.        |..|..|..::::..|..
Mouse   615 WKTFFALGRGPSIPRKKPLPWLGGSRAPPQPSGSRPDTV--------TLRSAKSEESLSSQASGA 671

  Fly  1535 TIQQRRAQRKAVQSICDQALILLLPTPVSSVSLPFQSLDYAKASASASASASSTASTSSSSTLHS 1599
            .:|:....|:...|   .....:.|.|..|..           |.|:|:|:||::|:||||...:
Mouse   672 GLQRLHRLRRPHSS---SDAFPVGPAPAGSCE-----------SLSSSSSSSSSSSSSSSSESSA 722

  Fly  1600 GGKASASSSSSSTTK----------FS-------------SSSSSACSTTAVAISSSISATSSKL 1641
            ||....|.|.|..|.          ||             ...:..||:......:..::.:...
Mouse   723 GGLGPLSGSPSHRTSAWLDDGDDLDFSPPRCLEGLRGLDFDPLTFRCSSPTPGDPAPPASPAPPA 787

  Fly  1642 LSANFKKRSTGGFLGSRSSH-QTRKASLDEKDSGQSSG-----SLGHSLGVGINLAKEQQRSSVD 1700
            .::.|..|:|...|   |.| .|:.||....|..:...     ::...||.|...|......::.
Mouse   788 SASAFPPRATPQAL---SPHGPTKPASPTALDISEPLAVSVPPAVLELLGAGGTPASATPTPALS 849

  Fly  1701 ---ISILLTDDDSSSRLSDTGSMSLTTITDTLDSKLRNLRS--GSESNDENGSPEFPKNRRHTLG 1760
               |.:||.  .:.::||||....::       |||...|.  |.:|.....||..|.      .
Mouse   850 PHLIPLLLR--GAEAQLSDTCQQEIS-------SKLAPTRGAPGQQSPGGMDSPLLPP------P 899

  Fly  1761 QPLHMHSENIPYADESPERLFHQFCNPLETAPLSLHLSRSCTATNTIGGDEKPSKQSGGVAPLPP 1825
            .||.......|...::|.||            ::|.|:......    .:::..::.||..|.|.
Mouse   900 LPLLRPGGAPPPPPKNPARL------------MALALAERAQQV----AEQQSQQEQGGTPPAPH 948

  Fly  1826 SLLKAAHKLQHSATVPIHQGSSTAPTSGAATPVGTPTGSG---------GAGA------IPSRSS 1875
            |..:.:..|:                 ....|||| :|||         ||.|      :|.:.|
Mouse   949 SPFRRSLSLE-----------------VGGEPVGT-SGSGIHPPSLAHPGAWAPGPPPYLPRQQS 995

  Fly  1876 SSSVTTLTKSI-----QPRFSNYLS-YERGNAAAGGAERVVGSAGGAASDDDSEGSTTSDPKEKL 1934
            ..|:....:.:     .||..:.:| :.|.:.|...|..:...:..:.....|..|..|.|:|.|
Mouse   996 DGSLVRSQRPLGTSRRSPRGPSQVSAHLRASGAYRDAPEMAAQSPCSVPSQGSNPSFFSTPRECL 1060

Fly 1935 1934
Mouse 1061 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	63/236 (27%)
Arhgap33	NP_001276611.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..64		16/56 (29%)
		PX_domain	80..192	CDD:383026	18/115 (16%)
		SH3_ARHGAP32_33	214..267	CDD:212769	7/68 (10%)
		RhoGAP_CdGAP	335..529	CDD:239849	58/203 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..818		57/278 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	864..1054		48/236 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1115..1305
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940