DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment RhoGAP19D and pac-1

DIOPT Version :9

Sequence 1:NP_001285496.1 Gene:RhoGAP19D / 33048 FlyBaseID:FBgn0031118 Length:2206 Species:Drosophila melanogaster
Sequence 2:NP_498877.4 Gene:pac-1 / 176201 WormBaseID:WBGene00015418 Length:1605 Species:Caenorhabditis elegans


Alignment Length:1822 Identity:392/1822 - (21%)
Similarity:638/1822 - (35%) Gaps:550/1822 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   254 AAPPHQHQQQQQQLISYPA----VAAVTTSTPA------GSPQSQSQSQSHSHPNTHHAPSLHGG 308
            |.||:.||||.|..:...|    :..|::..|:      ||.|.:            |.|:...|
 Worm    68 AMPPNGHQQQYQPQLRRKANTTNIVDVSSQVPSARNAIYGSWQDR------------HRPTRLYG 120

  Fly   309 SRSGSITSTASGGITVLSQPFYPQQQQQQQQQQQHRHPALTGGSSSIDFGDMAHGLRQHQQQQQH 373
            |:..|.:||.         |.|       .|...:....|||..|:....  ..|:|:       
 Worm   121 SQLVSSSSTL---------PKY-------DQLYCNTASPLTGNGSTNTIA--TTGIRR------- 160

  Fly   374 LYQQQQQHHQFMRANQPPNLTVLSASSATNTPTPTARQPKSATSHNQALYAVGAGPSSAA----- 433
                           :||....:..|.:|...|.:..:|.......::...:..|..|.|     
 Worm   161 ---------------EPPEYGNVGRSVSTWQVTNSEHRPSLQAGWLKSSRPLARGALSPAAYFRD 210

  Fly   434 -----GSGS-----GSLS--------------GGSENSDLMIRLRESIKQKEEFLKSPVPASMSS 474
                 |||:     |.||              |.:..||.:...:.|:..:.:.|.:      ..
 Worm   211 LENRHGSGASSPIVGGLSVVAVPITQRHAPTAGLAPISDDISTSKVSLDTENQQLNN------ED 269

  Fly   475 ASSINGNQAQSSSPAQQQHLQQHQQHFFPSHTPPGGVQVVVPPPRSRHQVMLKQQQQQQQQHQQH 539
            :..|:|:....::|.|...:...|:|                        .||:.....:.    
 Worm   270 SDKISGSALSRNTPRQASFMAAMQRH------------------------PLKESSTSIES---- 306

  Fly   540 HVLGYDMYHSGGKLVQRSSTAPGSVCHQHQQQQQHHLYHQQQHQQLQQTQHRQVMINNNAKYAKD 604
                    :.||...:...|...:......:...|.  ..::.|::.:|..|:.. |.||     
 Worm   307 --------NGGGTNTEEDQTVSATSKEDPSEDTGHD--DPEETQEISETPIRRSR-NRNA----- 355

  Fly   605 LDYFETLQETGVTNKVFERKLVSHMSKGFDPFKPLSINTSALESSASTSSTSATTTVKKQSVLYE 669
                      .:.|:...|.|     .|.| |:.|.:.|:.:..|...::.:.|::         
 Worm   356 ----------SLRNRQSSRSL-----GGLD-FEKLRMGTARVGDSNEATAENGTSS--------- 395

  Fly   670 SLQQHPLAKYHQTQQQTTTTTTVDGQTSSRMELHKATLANATIDPVPVGSSKFVTLPDKPDKGSS 734
                          ..:...:..||.|||               |..|....|.|        ||
 Worm   396 --------------SSSRKNSRDDGLTSS---------------PTTVAGPVFTT--------SS 423

  Fly   735 VATLADIAESSAAAIVDSASGSGNVVRRYKPLSSSSFDEG-----KPMRRI---SYLRATN---N 788
            .::::...|:|:.|:..:|:||.......:..|:||.|..     |.:||.   ||:.||:   |
 Worm   424 TSSISTSGEASSTAVAAAAAGSVAATTSRQTSSNSSVDSNHNEAMKMIRRARPKSYVLATSASMN 488

  Fly   789 ETDFNAEAAA-------GGDAAATGASGPAS-----------ASAASSAPGPTPSSAPAPAPAPA 835
            |...::...|       ..|...:|...|:|           :..||||...|.|::        
 Worm   489 EDVLSSSIIANEQSSSISHDTTTSGRELPSSLMGSTISMEMRSGGASSATTTTTSNS-------- 545

  Fly   836 PLPISIPIPVAAVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGLEDVRLSAHGSRRASM 900
                          ..|.::||...||..|:.:       ..||...|..:    ::.||.....
 Worm   546 --------------GQQTSRSLNAPHPPATHRL-------QRFIALFNSSK----TSDGSGEHKK 585

  Fly   901 SSDMRSSIHIDAE---LNGKYVPNELEAFETEIEIKSSCI--NGKRMSEYRSW-----RQVKLEI 955
            |...||...:.|.   |.|..:..:..|.:|.::.:...:  :|||.:....|     |.:.|.:
 Worm   586 SRMKRSRTSLPASRFALPGTILQRDGVARQTWVKHQEIALGKSGKRNNWEDRWAVLCRRSLYLCV 650

  Fly   956 KGDLL----RIYSGRHAKSEHNVIELDIRN------FKFFDESMDKKKYLIRMQSKPSPSGAHLA 1010
            :....    .|..|.|.:       :|:.|      :.:...|..|:::::|:.::  ....||.
 Worm   651 ESPAYTTEKTIELGSHTR-------VDVCNAIVDIAYDWLSSSFSKQRHVVRIVTQ--NRSEHLI 706

  Fly  1011 SLGNELNL--------DEGHDKLLTSSG--------SSSANEPAANAASAL------TASTSSST 1053
            .|..|..:        ....|.:.|.|.        :...|..|.:.:|||      .||.:||:
 Worm   707 ELNTESEMLSWISVLQSSSEDGIATGSSVDENELSTTGRHNNNAVSNSSALLHNSQSIASLASSS 771

  Fly  1054 CSSGPYTEILFKTKSSNEMKRLFGLLQWKDSLNYDDNEHQPQGKQLAEPQKTVASASYLDDVQGG 1118
            ||:...:|.|      |....|               :.|.|.:...:.|:||...|        
 Worm   772 CSTATTSEFL------NSQHTL---------------QQQQQQQTNQKHQQTVNELS-------- 807

  Fly  1119 ASAADSSPLSSHSGGIADASGS-----------HHV----SALPAAAAIVAATSD-----SISPV 1163
            |......|.|...||::..:.|           |..    |.|.:..|.....:|     |.|..
 Worm   808 AGIVSHLPTSKSFGGLSTTASSTTENAKNRLIMHRYIAKNSQLQSPTANKKMETDPSTVPSSSQT 872

  Fly  1164 MKARKSSSHKHI----PDKDL----------GSPKS-KNWKDLLFRRGGSGSGGVSHHDLASPSA 1213
            |....||.|.|.    |.:|:          .:||| :.||.....:.|||.|       :|.|:
 Worm   873 MATTSSSFHHHSSQAGPSRDIENGEAPTATATTPKSGRKWKKSKAAKQGSGGG-------SSGSS 930

  Fly  1214 CAAKQIGSIGVP-------LRSCPMSKVNAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISE 1271
            ..::|.|:.|.|       :..||......:||.:|:.|..::||.|:..|||||||||.||::.
 Worm   931 SGSQQQGAAGAPQPVLGVRIADCPTGSCEDHVPMIVQACVCVIETYGMDTVGIYRIPGNTAAVNA 995

  Fly  1272 LSELVNTKDF------QFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYINFIEADK-KF 1329
            |.|.::.:.|      :.||.  |.||.||||||||||:|:|.||:.|:....|..||:|:: ..
 Worm   996 LKESLSNRGFDSVDLSKVESL--DPRWRDVNVVSSLLKMFLRKLPEPLLTDKLYPFFIDANRIST 1058

  Fly  1330 GLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLET 1394
            ...|:..||.::..|||..|:|::.||.||..::.:.|||:||.:|||::|||||:|..:|.:.|
 Worm  1059 HHNRLHKLRNLLRKLPRPHYDTLRFLIVHLSEITKHSDVNKMECRNLALMFGPSIVRPSDDNMAT 1123

  Fly  1395 AVKDMKHQCRIVELLVTQYDYFFEGGSLPDIAEVS-----------------GGTAAVSAAQPQ- 1441
            .|..|..||:|:|.|:....:.|:..|..:.|...                 |....||||... 
 Worm  1124 MVTHMSDQCKIIETLIHYNLWMFDESSTTEDAVPEQHPADGQNPLEPGGYGVGVPTGVSAASFND 1188

  Fly  1442 -----QQTQEDQTSMLLHNLSKIERITE--RETTRTSRFMPQLR---------------RKTHGK 1484
                 ::..|||.:.:: |..|.::|..  |..:|..:...:|:               :.|...
 Worm  1189 MHNLIRKANEDQAAAMM-NEGKGQKIKNMLRRNSRRDKSKSKLKIESTAPAAVNPRGWTQPTPSN 1252

  Fly  1485 RSA---------------VNSDTYSGESV---LVSGSSSNTTTTTTTTTHTTSSTSSSNTITTTI 1531
            .||               ::::..|.::|   :.|||:..  .::|....:.|..||..::..|.
 Worm  1253 TSAASVESAFCGNYQERDIDAEIESRQTVSPQMTSGSADG--ASSTRLDQSPSLESSLGSLPDTS 1315

  Fly  1532 STTTI---------QQRRAQRKAVQSICDQALILLLPTPVSSVSLPFQSLDYAKASASASAS--- 1584
            .|..|         :.:.|.|:..|.....|..:.:.....:.:....:.|..||:..|.|:   
 Worm  1316 RTEPILGSSGYDDDEAKEAARRKRQEEMYSARRIFIAGAAGAAAAATTTADAEKAAIDALANHSQ 1380

  Fly  1585 ----ASSTA-STSSSSTLHSGGKASASSSSSSTTKFSSS------SSSACSTTAVAISSSISATS 1638
                |||.| ...|..|.....:.....|...|.:..|.      |.:...|.|::.:|..|.||
 Worm  1381 HLHLASSPAFEVLSEETREKIRRMQKKQSWHDTKELRSGELLKTYSPTKDLTDALSCTSDYSTTS 1445

  Fly  1639 SKLLSAN--------FKKRSTGGFLGSRSSHQTRKASLDEKDSGQSSGSLGHSLGVGINLAKEQQ 1695
            |..||.|        .:..|:..:..|..|...|..|       .|..|...:|.:         
 Worm  1446 SAPLSTNPPLAVACADQPNSSSDYASSDPSPCARNPS-------TSPASRPSNLAI--------- 1494

  Fly  1696 RSSVDISILLTDDDSSSRLSDTGSMSLTTITDTLDSKLRNLRSGSESNDENGSPEFPKNRRHTLG 1760
                          |.::|..|.|...:....:...|:| ||:...|.|        ..|||||.
 Worm  1495 --------------SPAQLHATSSSGQSHQPMSRSQKIR-LRTKLGSRD--------PARRHTLS 1536

  Fly  1761 Q----------------PLHMHSENIPYADESPERLFHQFCNPLETAPLSLHLSRSCTATNTIGG 1809
            .                .:...|.::...:.|.:...||...||..|...:.:..|......:.|
 Worm  1537 DVDTLKEGRLDKLARWFGIRKSSPDVSRDEVSDDEKNHQEAPPLPAAAPPVIVRTSPNELTPVSG 1601

  Fly  1810 DE 1811
            ||
 Worm  1602 DE 1603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RhoGAP19DNP_001285496.1 PDZ_signaling <151..205 CDD:238492
RhoGAP_ARHGAP21 1221..1417 CDD:239860 84/209 (40%)
pac-1NP_498877.4 PH_ARHGAP21-like 613..728 CDD:269955 20/123 (16%)
PH 617..726 CDD:278594 18/117 (15%)
RhoGAP_ARHGAP21 945..1146 CDD:239860 82/202 (41%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160159505
Domainoid 1 1.000 134 1.000 Domainoid score I3114
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - oto19854
orthoMCL 1 0.900 - - OOG6_104725
Panther 1 1.100 - - LDO PTHR23176
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2255
SonicParanoid 1 1.000 - - X1550
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.960

Return to query results.
Submit another query.