Protein Alignment RhoGAP19D and Arhgap31

DIOPT Version :9

• Sequence 1: NP_001285496.1
• Gene: RhoGAP19D / 33048
• FlyBaseID: FBgn0031118
• Length: 2206
• Species: Drosophila melanogaster
• Sequence 2: NP_064656.2
• Gene: Arhgap31 / 12549
• MGIID: 1333857
• Length: 1425
• Species: Mus musculus
• Alignment Length: 1014
• Identity: 210/1014 - (20%)
• Similarity: 352/1014 - (34%)
• Gaps: 284/1014 - (28%)

  Fly  1184 KSKNWKDLLFRRGGSGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNI 1248
            |:|..|..|.|:|.:.:.|.   ||       .:.:.|.|..            ||::::.|...
Mouse     2 KNKGAKQKLKRKGAASAFGC---DL-------TEYLESSGQD------------VPYVLKSCAEF 44

  Fly  1249 VETKGLGVVGIYRIPGNKAAISELSELVNTKDFQFESCASDDR---WEDVNVVSSLLKLFIRSLP 1310
            :||.|: |.||||:.|..:.|..|.:     :|..:.|....|   .:|::.|.||.||:.|.||
Mouse    45 IETHGI-VDGIYRLSGITSNIQRLRQ-----EFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELP 103

  Fly  1311 DALMPASYYINFIEADKKFGLE-RIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPK 1374
            :.|:....|..|.||......| ::..::.::..||...|.|:::|||||..::.......|..:
Mouse   104 NPLLTYELYEKFTEAVSHRPEEGQLARIQNVILELPPPHYRTLEYLIRHLAHIASFSSKTNMHAR 168

  Fly  1375 NLAIIFGPSIIRTP--NDTL---ETAVKDMKHQCRIVELLVTQYDYFFEGGSLPDIAEVSGGTAA 1434
            |||:::.|:::|:.  ..|:   :.|...::.|..::|.::...|..|.||:...:.:....|..
Mouse   169 NLALVWAPNLLRSKKIEATICNGDAAFLAVRVQQVVIEFILNHADQIFNGGAPGALQQDESRTIT 233

  Fly  1435 VSAAQPQ-------QQTQEDQT-SMLLHNLSKIERITERETT---------RTSRFMPQLRRKTH 1482
            .|...|.       ...:|.|. |:..::.::.||   ||.:         .|...:|..:||..
Mouse   234 KSLTLPALSLPMKLVSLEEAQARSLATNHPARKER---RENSLPEIVPPPFHTVLELPDNKRKLS 295

  Fly  1483 GK----RSAVN-----SDTYS----GESVLVSGSSSNTTTTTTTTTHTTSSTSS----------- 1523
            .|    :|..|     ||:.|    ..||.|.|...:....|.....:..|..|
Mouse   296 SKSKKWKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVEKATIRPAKSMDSLCSVPVEGKENKGN 360

  Fly  1524 -SNTITTTISTTTIQQRRAQRKAVQSICD------------------------------QALILL 1557
             |.|:||  ....|...:....:..|.||                              :.|.:.
Mouse   361 FSRTVTT--GGFFIPATKMHASSTGSSCDLSKEGEWGQEGMPAGAEGGCEVGGQIRPLPEQLKVF 423

  Fly  1558 LP--TPVSSVSLP-FQSLDYAKASASASASASSTASTSSSSTLHSG-----GKASASSSSSSTTK 1614
            .|  .|.|..|.| ...:.|..:.:...:..:|:......|..|..     .:..|.|.....:.
Mouse   424 RPIGDPESEQSAPKLLGMFYTSSDSPGKSVFTSSLFQMEPSPRHQRKALNISEPFAVSVPLRVSA 488

  Fly  1615 FSSSSSSACSTTAVAISSSISATSSKLLSANFKKRSTGGF------LGSRS--SHQTRKASLDEK 1671
            ..|::|:.|.|....:.|     .|.|...:|:...:||:      ||:.|  ...|:||:.::.
Mouse   489 VISTNSTPCRTPPKELQS-----LSSLEEFSFQGSESGGWPEEEKPLGAESFPGSVTKKAATEDT 548

  Fly  1672 ------------------DSGQSSGSLGHSLGVGINLAKEQQRSSVDISILLTDDDSSSRLSDTG 1718
                              |.|.........:.:|..::||.::......::.....:|.....|.
Mouse   549 KPEPEVPGRAECSQSPPLDPGTQVEKKTLHVSLGSQVSKEAEKRPKAEKVMEESQGASQPKPSTP 613

  Fly  1719 SMSLTTITDTL-------------------DSKLRNLRSGSESND-----ENGSP---------E 1750
            ..||...|:.|                   ..:|:.:.|..|.:.     :..||         .
Mouse   614 QESLGAGTEPLILHEMDEEDLAQALIWPEIQQELKIIESEEEFSSLPPAAQKTSPIPESSPAPFP 678

  Fly  1751 FPKNRRHTLGQPLHMHSENIP-------YADES---------PERLFHQFCNPLET--------- 1790
            ||:       .|..:.|.:.|       .|::|         .|:| ...|:.||:
Mouse   679 FPE-------APGSLPSSSAPREVWTRDAANQSIQEAAILTDREKL-EPVCSLLESESQQELSPD 735

  Fly  1791 ----APLSLHLSR--SCTATNTIGGDEKPSKQSGGV--APLPPSLLKAAHKLQHSATVPIHQGSS 1847
                |||.:.|..  |..|...|||   |...|..:  ||.||:.|:...::..|...|..:.::
Mouse   736 PASLAPLEMLLFEKVSSPARIEIGG---PRNLSPPLTPAPPPPTPLEEEPEVLLSKEGPDREDAA 797

  Fly  1848 TAPTSGAATPVGTPTGSGG---------AGAIPSRSSSS----------SVTTLTKSIQPRFSNY 1893
            ....:...|...||..|.|         |.|.|:...::          .:.:.||.:     :.
Mouse   798 RDSRTDVYTEQPTPKESPGIPTPCQREEAIASPNEKQNARHAVPENKGPGLPSPTKEV-----DI 857

  Fly  1894 LSYERGNAAAGGAERVVGSAGGAASDDDSEGSTTSDPKEKLLLGERP------------SPSF-- 1944
            :..|.|.|.....|         .||.| |..|.:||.:..|....|            ||:.
Mouse   858 IPQEEGGAPHSAQE---------PSDCD-EDDTVTDPAQHGLEMVEPWEEPQWVTSPLHSPTLKE 912

  Fly  1945 FIERYNKKRRDHRLFRSASFNCRNYSTRH---ITAQTSG 1980
            ..|...:..:.|||.|..   |...|.|.   :.::|:|
Mouse   913 VQESQTQGSQGHRLERRL---CHRPSLRQSHSLDSKTTG 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
		RhoGAP_ARHGAP21	1221..1417	CDD:239860	54/204 (26%)
Arhgap31	NP_064656.2	RhoGAP_CdGAP	17..211	CDD:239849	56/221 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..277		4/21 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	511..621		18/109 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	652..700		9/54 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	756..951		47/214 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1031..1095
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1196..1260
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1291..1327

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030