Protein Alignment RhoGAP19D and ARHGAP33

DIOPT Version :9

• Sequence 1: NP_001285496.1
• Gene: RhoGAP19D / 33048
• FlyBaseID: FBgn0031118
• Length: 2206
• Species: Drosophila melanogaster
• Sequence 2: XP_006723062.1
• Gene: ARHGAP33 / 115703
• HGNCID: 23085
• Length: 1298
• Species: Homo sapiens
• Alignment Length: 1181
• Identity: 237/1181 - (20%)
• Similarity: 386/1181 - (32%)
• Gaps: 415/1181 - (35%)

  Fly  1002 PSPSGAHLASLGNELNLDEGHDKLLTS---SGSSSANEPAANAASALTASTSSSTCSSGPYTEIL 1063
            |.|..|..|....| |:|.||.:||.|   .|.|.:.|                       .|::
Human    42 PFPRLADCAHFHYE-NVDFGHIQLLLSPDREGPSLSGE-----------------------NELV 82

  Fly  1064 FKTKSSNEMKRLFGLLQWKDSLNYDDNEHQ----------------PQGKQLAEPQKTVASASYL 1112
            |..:.:.:.:....|..:.|..:.|.:.|:                |:|.:.|: ........||
Human    83 FGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRRFSCLPELPPPPEGARAAQ-MLVPLLLQYL 146

  Fly  1113 DDVQGGASAADSS----------PLSSHSGG-IADASGSHHVSALPAAAAIVAATSDSISPVMKA 1166
            :.:.|   ..||:          .|.:|... :.....|.::.|:.||..|...|:.:
Human   147 ETLSG---LVDSNLNCGPVLTWMELDNHGRRLLLSEEASLNIPAVAAAHVIKRYTAQA------- 201

  Fly  1167 RKSSSHKHIPDK------------DLGSPKSKNW----------------KDLLFRRGGSG---- 1199
                     ||:            |:...:.::|                .:|...|.|.|
Human   202 ---------PDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFFPSECVELFTERPGPGLKAA 257

  Fly  1200 -----------SGGVSHHDLASPSACAAKQIGSIGVPLRSCP----------------------- 1230
                       ..|:|....|.|.. ..|..|.:...:||.|
Human   258 DADGPPCGIPAPQGISSLTSAVPRP-RGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEH 321

  Fly  1231 MSKVNAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSELVNTKDFQFES-----CASDD 1290
            :|.....||.::..|:..:|..|: |.||||:.|..:.|..|..       :|:|     .:...
Human   322 LSNSGQDVPQVLRCCSEFIEAHGV-VDGIYRLSGVSSNIQRLRH-------EFDSERIPELSGPA 378

  Fly  1291 RWEDVNVVSSLLKLFIRSLPDALMPASYYINFIEADKKFG-LERIVLLREIVESLPRHPYETMKH 1354
            ..:|::.||||.||:.|.||:.|:....|..|.||....| .||:|.:.::::.||...|.|:::
Human   379 FLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEY 443

  Fly  1355 LIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLET-------AVKDMKHQCRIVELLVTQ 1412
            |:|||.|::.:.....|..:||||::.|:::|:..  ||:       |.::::.|..:||.|:|.
Human   444 LLRHLARMARHSANTSMHARNLAIVWAPNLLRSME--LESVGMGGAAAFREVRVQSVVVEFLLTH 506

  Fly  1413 YDYFFE----------------------GGSLPDIAEVSGGTAAVSAAQPQQQTQEDQTSMLLHN 1455
            .|..|.                      .||.|       .|..::..:.|.:||
Human   507 VDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSCP-------STRLLTLEEAQARTQ---------- 554

  Fly  1456 LSKIERITERETTRTSRFMPQLR-------RKTHGKRSAVNSDTYSGESVLVSGSSSNTT----- 1508
             .::...||..|.:......:.|       |:..|:|         ||.....|.||..|
Human   555 -GRLGTPTEPTTPKAPASPAERRPPVSPPNRRRKGER---------GEKQRKPGGSSWKTFFALG 609

  Fly  1509 -----------------------TTTTTTTHTTSSTSSSNTITTTISTTTIQQRRAQRKAVQSIC 1550
                                   :.:...|.|..|..|..::::..|...:|:....|:...|
Human   610 RGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAGLQRLHRLRRPHSS-- 672

  Fly  1551 DQALILLLPTPVSSVSLPFQSLDYAKASASASASASSTASTSSSSTLHSGGKASASSSSSSTTK- 1614
             .....:.|.|..|.    :||     |:|:|:.:||:.|:||||...:.|..:.|.|.|..|.
Human   673 -SDAFPVGPAPAGSC----ESL-----SSSSSSESSSSESSSSSSESSAAGLGALSGSPSHRTSA 727

  Fly  1615 ---------FS-------------SSSSSACSTTAVAISSSISATSSKLLSANFKKRSTGGFLGS 1657
                     ||             ...:..||:......:..::.:....::.|..|.|...:..
Human   728 WLDDGDELDFSPPRCLEGLRGLDFDPLTFRCSSPTPGDPAPPASPAPPAPASAFPPRVTPQAISP 792

  Fly  1658 RSSHQTRKASLDEKDSGQSSGSLGHSLGVGINLAKEQQRSSVDISILLTDDDSSSRLSDTGSMSL 1722
            |               |.:|.:...:|.:...||     .||..::|       ..|...|:.:.
Human   793 R---------------GPTSPASPAALDISEPLA-----VSVPPAVL-------ELLGAGGAPAS 830

  Fly  1723 TTITDTLDSKLRNLRSGSESNDENGSPEFPKNRRHTLGQPLHMHSENIPYADESPERLFHQFC-- 1785
            .|.|..| |..|:||.                  |.:  ||.:.....|..|...:    :.|
Human   831 ATPTPAL-SPGRSLRP------------------HLI--PLLLRGAEAPLTDACQQ----EMCSK 870

  Fly  1786 -------------NPLETAPLSLHLSRSCTATNTIGGDEKPSKQSGGVAPLPPS------LLKAA 1831
                         :||...||||                   .:.||..|.||.      .|..|
Human   871 LRGAQGPLGPDMESPLPPPPLSL-------------------LRPGGAPPPPPKNPARLMALALA 916

  Fly  1832 HKLQHSATVPIHQGSSTAPTSGAATPV---------GTPTGSGGAGA------------------ 1869
            .:.|..|.....|.....|.: :.:|.         |.|.|:.|:|.
Human   917 ERAQQVAEQQSQQECGGTPPA-SQSPFHRSLSLEVGGEPLGTSGSGPPPNSLAHPGAWVPGPPPY 980

  Fly  1870 IPSRSSSSSVTTLTKSIQPRFSNYLSYERGNAAAGGAERVVGSAGGAASDDDSEGSTTSDPKEKL 1934
            :|.:.|..|   |.:|.:|..::.... ||.|......|..|  ||..:.:.:..|..|.|.:.
Human   981 LPRQQSDGS---LLRSQRPMGTSRRGL-RGPAQVSAQLRAGG--GGRDAPEAAAQSPCSVPSQV- 1038

  Fly  1935 LLGERPSPSFF 1945
                 |:|.||
Human  1039 -----PTPGFF 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
		RhoGAP_ARHGAP21	1221..1417	CDD:239860	63/231 (27%)
ARHGAP33	XP_006723062.1	PX_domain	56..168	CDD:295365	24/138 (17%)
		SH3_ARHGAP32_33	190..243	CDD:212769	8/68 (12%)
		RhoGAP_CdGAP	312..506	CDD:239849	58/203 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940