DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and Bcr

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_001074881.1	Gene:	Bcr / 110279	MGIID:	88141	Length:	1270	Species:	Mus musculus

Alignment Length:	1313	Identity:	251/1313 - (19%)
Similarity:	429/1313 - (32%)	Gaps:	382/1313 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 SPSLLANGSHKTTFPAAAAVA-----APPHQHQQQQQQLISYPAVAAVTTS------TPAGSPQS 287
            |||...:.|.:.  |||||.|     .||             .:|||:.::      .||....:
Mouse   122 SPSKGRSASARR--PAAAASADRDDRGPP-------------TSVAALRSNFEKIRKGPAQPGSA 171

  Fly   288 QSQSQSHSHPNTHHAPSL---HGGSRSGSITSTASGGITVLSQPFYPQQQQQQQQQQQ------- 342
            .::...:.:...||...|   :....|..|:|..       ||....::::.||...|
Mouse   172 DAEKPFYVNVEFHHERGLVKVNDKEVSDRISSLG-------SQAMQMERKKSQQSAGQGLGEAPR 229

  Fly   343 -HRHPALTGGSSSIDFGDMAHGLRQHQQQQQHLYQQQQQHHQFMRANQPPNLTVLSASSATNTPT 406
             |.....:..|..:| ||               |:..:.:.:|::.|      :::|:.....|.
Mouse   230 PHYRGRSSESSCGLD-GD---------------YEDAELNPRFLKDN------LINANGGNRPPW 272

  Fly   407 PTAR-QPKSATSHNQALYAVGA------------------------------GPSSAAGSGSGSL 440
            |... ||      .|::|..|.                              .|.|...||.|..
Mouse   273 PPLEYQP------YQSIYVGGMMVEGEGKSPLLRSQSTSEQEKRLTWPRRSYSPRSFEDSGGGYT 331

  Fly   441 SGGSENSDLMIRLRESIKQKEEFLKSPVPASMS-SASSINGNQAQSSSPAQQQHLQQHQQHFFPS 504
            ...|.|        |::...||...|...:.:| |.::....:.:|.||:      |:.|..|.|
Mouse   332 PDCSSN--------ENLTSSEEDFSSGQSSRVSPSPTTYRMFRDKSRSPS------QNSQQSFDS 382

  Fly   505 HTPPGGVQVVVPPPRSRHQVMLKQQQQQQQQHQQHHVLGYDMYHSG-----------------GK 552
            .:||                    ..|.|::|:|..|:..:....|                 |:
Mouse   383 SSPP--------------------TPQCQKRHRQCQVVVSEATIVGVRKTGQIWPSDGDSTFQGE 427

  Fly   553 LVQRSSTAPGSVCHQHQQQQQHHLYHQQQHQQLQQTQHRQVMINNNAK-----------YAKDLD 606
            ......|.||..|...|.::|..  ||.....:..:......:::..:           ...:||
Mouse   428 ADSSFGTPPGYGCAADQAEEQRR--HQDGLPYIDDSPSSSPHLSSKGRGSLASGALDPTKVSELD 490

  Fly   607 YFETLQE-----TGVTNKVFERKLVSHMSKGFDPFKPLSINTSALESSASTSSTSATTTVKKQSV 666
            ..:.|:.     :|:.  ..|...:||:.....|.|||        .:|:|:|....|:.:.:::
Mouse   491 LEKGLEMRKWVLSGIL--ASEETYLSHLEALLLPMKPL--------KAAATTSQPVLTSQQIETI 545

  Fly   667 LYESLQQHPLAK------YHQTQQQTTTTTTVD--GQTSSRMELHKATLANATIDPVPVGSSKFV 723
            .::..:.:.:.|      :.:.||.:......|  .:.:|::.:::|.:.|            :.
Mouse   546 FFKVPELYEIHKEFYDGLFPRVQQWSHQQRVGDLFQKLASQLGVYRAFVDN------------YG 598

  Fly   724 TLPDKPDKGSSV-ATLADIAESSAAA----IVDSASGSGNVVRRYKPLSSSSFDEGKPMRRISYL 783
            ...:..:|.... |..|:|:|:..|.    :.||.:.:......|||:.
Mouse   599 VAMETAEKCCQANAQFAEISENLRARSNKDVKDSTTKNSLETLLYKPVD---------------- 647

  Fly   784 RATNNETDFNAEAAAGGDAAATGASGPASASAASSAPGPTPSSAPAPAPAPAPLPISIPIPVAAV 848
            |.|.                        |..........||||.|..:.....|.||
Mouse   648 RVTR------------------------STLVLHDLLKHTPSSHPDHSLLQDALRIS-------- 680

  Fly   849 VEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGLEDVRLSAHGSRRASMSSDMRSSIHIDAE 913
               |...|.:.|...|....:....|.|..:...:.:.::...|...|...:.:|:.....:..:
Mouse   681 ---QNFLSSINEEITPRRQSMTVKKGEHRQLLKDSFMVELVEGARKLRHIFLFTDLLLCTKLKKQ 742

  Fly   914 LNGK--------YVP-----------------------NELEAFETEI-EIKSSCINGKRM---S 943
            ..||        |:|                       .||:|.:.:| :|||.....||.   |
Mouse   743 SGGKTQQYDCKWYIPLTDLSFQMVDELEALPNIPLVPDEELDALKIKISQIKSDIQREKRANKGS 807

  Fly   944 EYRSWRQVKLEIKGDLL---------RIYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQ 999
            :.....:.||..:..||         |::| |:.||...:|..|....::.:...:::|...:..
Mouse   808 KVMERLRKKLSEQESLLLLMSPSMAFRVHS-RNGKSYTFLISSDYERAEWRESIREQQKKCFKSF 871

  Fly  1000 SKPSPSGAHLASLGNE-LNLDEGHDKLLTSSGSSSANEPAANAASALTASTSSSTCSSGPYTEI- 1062
            |..|   ..|..|.|. :.|...|...||.:.....:.........:..|.:....||..|..:
Mouse   872 SLTS---VELQMLTNSCVKLQTVHHIPLTINKEDDESPGLYGFLHVIVHSATGFKQSSNLYCTLE 933

  Fly  1063 -----LFKTKSSNEMKRLFGLLQWKDSLNYDDNEHQPQGKQLAEPQKTVASASYLDDVQGGASAA 1122
                 .|..|:...:.|......|.:..     |.:.:|.|      |:....|       ....
Mouse   934 VDSFGYFVNKAKTRVYRDTTEPNWNEEF-----EIELEGSQ------TLRILCY-------EKCY 980

  Fly  1123 DSSPLSSHSGGIAD-ASGSHHVSALPAAAAIVAATSDSISPVMKARKSSSHKHIPDKDLGSPKSK 1186
            :...::...|..|| ..|...|...|                         :.:.|:|
Mouse   981 NKMKMTKEDGESADKLMGKGQVQLDP-------------------------QTLQDRD------- 1013

  Fly  1187 NWKDLLFRRGG---SGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNI 1248
             |:..:....|   ..|...:..:.:.....:.||.|..||.: :....:..:.||::|..|...
Mouse  1014 -WQRTVIDMNGIEVKLSVKFTSREFSLKRMPSRKQTGVFGVKI-AVVTKRERSKVPYIVRQCVEE 1076

  Fly  1249 VETKGLGVVGIYRIPGNKAAISELSEL--VNTKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPD 1311
            :|.:|:..|||||:.|....|..|...  ||.||........     |||.::..|||:.|.||:
Mouse  1077 IERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEM-----DVNAIAGTLKLYFRELPE 1136

  Fly  1312 ALMPASYYINFIEA---DKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEP 1373
            .|....:|.||.|.   ......|..:|  .::.|||.....|...|:.||.||:....||:|..
Mouse  1137 PLFTDEFYPNFAEGIALSDPVAKESCML--NLLLSLPEANLLTFLFLLDHLKRVAEKETVNKMSL 1199

  Fly  1374 KNLAIIFGPSIIR 1386
            .|||.:|||:::|
Mouse  1200 HNLATVFGPTLLR 1212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	55/171 (32%)
Bcr	NP_001074881.1	Kinase. /evidence=ECO:0000250\|UniProtKB:P11274	1..428		73/389 (19%)
		Bcr-Abl_Oligo	3..75	CDD:286168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..173		17/65 (26%)
		Binding to ABL SH2-domain. /evidence=ECO:0000250	198..387		46/257 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..249		13/70 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..396		25/134 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..481		9/70 (13%)
		RhoGEF	501..689	CDD:279015	43/260 (17%)
		PH-like	683..876	CDD:302622	36/196 (18%)
		C2_ABR	912..1032	CDD:176068	24/170 (14%)
		RhoGAP_Bcr	1051..1251	CDD:239852	55/170 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940