DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and arhgap23

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	XP_004918722.1	Gene:	arhgap23 / 100496640	XenbaseID:	XB-GENE-1194381	Length:	1530	Species:	Xenopus tropicalis

Alignment Length:	2007	Identity:	433/2007 - (21%)
Similarity:	668/2007 - (33%)	Gaps:	723/2007 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 IQPKLIVIRRRPNQGFGFTLRHFIAYPPEDDQASSSASGLVSGSATAATAASVSTNWPQEASSAA 114
            :.|:.:|| |:...||||||||||.||||  .|.:|......|.|...:|||
Frog    85 VGPRTLVI-RKSQHGFGFTLRHFIVYPPE--SAVTSVHKEEDGGADLPSAAS------------- 133

  Fly   115 GSNSGSSSSVGVAGITGLEPTSPTSLPPYQVKAMETIFIKEVQANGPAHYANLQTGDRVLMVNNQ 179
                                         |::.|:|||:|:|:..|||..|.|.||||::.||.:
Frog   134 -----------------------------QLEPMDTIFVKQVKEGGPAQKAGLCTGDRLVKVNGE 169

  Fly   180 PIAGIAYSTIVSMIKQTPAVLTLHVVPKECDVLQMHYTSIAH---------------TPESNRLT 229
            .|.|..||.::::|:.:...|.|.::|::.|:||:.|:..|:               .|......
Frog   170 SIIGKTYSQVIALIQNSDDTLELSIMPRDEDILQLAYSQDAYLKGNEPYRGGAHSIPEPPPVYYP 234

  Fly   230 MSTHSP-SLLANGS--HKTTFPAAAAVAAPPHQ--------HQQQQQQLISYPAVAAVTTSTP-- 281
            ..||.| |..|..|  |......|.|:.:|.|.        |:.      :||..|..:.|..
Frog   235 WRTHEPVSGYAPASRYHHPNSADATAIRSPVHSEVPRGSPAHRD------NYPRTAPTSLSQARS 293

  Fly   282 -AGSPQSQSQSQSHSHPNTHHAPSLHGGSRSGSITSTASGGITVLSQPFYPQQQQQQQQQQQHRH 345
             .|||.|..:.:....|::.|  ..|......:..:.:......|:.|.:....:        ||
Frog   294 FQGSPSSSDRFRGPGPPHSSH--GWHSRYMQDAPRNVSPEPWERLASPRWVSPWE--------RH 348

  Fly   346 PALTGGSSSIDFGDMAHGLRQHQQQQQHLYQQQQQHHQFMRANQPPNLTVLSASSATNTPTPTAR 410
            .||....|                      ||..:....:    ||.....|......| |..:.
Frog   349 QALCSWMS----------------------QQAPRRGSAL----PPRRRSASQDRLGET-THLSN 386

  Fly   411 QPKSA---TSHNQALYAVGAGPSSAAGSGSGSLSGGSENSDLMIRLRESIKQKEEFLKSPVPASM 472
            .|.|.   |.|...||.                |.|..            .|.:.||..    ..
Frog   387 WPHSVSQDTLHQAPLYE----------------SWGHR------------AQSDNFLAQ----FG 419

  Fly   473 SSASSINGNQAQSSSPAQQQ--------HLQQHQQHFFPSHTPPGGVQVVVPPPRSRHQVMLKQQ 529
            :||..:| ..|..|.|.:.:        |..|......||.|...|::....||
Frog   420 TSAEKLN-LSALISPPYEHRIWPQDRPLHSSQAPSRVRPSQTVSPGLREATKPP----------- 472

  Fly   530 QQQQQQHQQHHVLGYDMYHSGGKLVQRSSTAPGSVCHQHQQQQQHHLYHQQQHQQLQQTQHRQVM 594
                |.|......||..|.|.....||.:                        :.|.....|:..
Frog   473 ----QPHPSSGDSGYIGYRSYSPSFQRRT------------------------ELLNAFSFRETA 509

  Fly   595 INNNAKYAKDLDYFETLQETGVTNKVFERKLVSHMSKGFDPFKPLSINTSALESSASTSST--SA 657
            .:.       |..|.|.|.:|....:.||:                      ||:.|.|||  |.
Frog   510 FSG-------LPTFRTEQYSGSPASLPERR----------------------ESAVSASSTDDSC 545

  Fly   658 TTTVKKQSVLYESLQQHPLAKYHQTQQQTTTTTTVDGQTSSRMELHKATLANATIDPVPVGSSKF 722
            :|..:::.|:   |:|.|     .:.::.||..       .::.||..|
Frog   546 STQERREEVV---LRQKP-----PSGRKATTAV-------RQVNLHFPT---------------- 579

  Fly   723 VTLPDKPDKGSSVATLADIAESSAAAIVDSASGSGNVVRRYKPLSSSSFDEGKPMRRISYL-RAT 786
                          .:.|:...::.::.:.|... ..::|..||..|.    :|:..|.:: ..|
Frog   580 --------------EVKDVEPPTSTSVSEEAPRE-RPLQRVPPLPPSE----EPLASIPFIDEPT 625

  Fly   787 NNETDFNAEAAAGGDAAATGASGPASASAASSAPGPTPSSAPAPAPAPAPLPISIPIPVAAVVEP 851
            :...|..|:..            |||...:|:.     :|||..:.:|:
Frog   626 SPSIDLRAKHV------------PASCVVSSAI-----NSAPVISASPS---------------- 657

  Fly   852 QKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGLEDVRLSAHGSRR-ASMSSDMRSSIHIDAELN 915
                       .|::                    ...:|.|.|:. :|:.|..|||.
Frog   658 -----------SPSF--------------------SFNISRHYSQDCSSIKSSRRSSY------- 684

  Fly   916 GKYVPNELEAFETEIEIKSSCINGKRMSEYRSWRQVKLEIKGDLLRIYSGRHAKSEHNVIELDIR 980
                   |.|..|  |...||.:|  ::.:|...:::..:.|   |:.|.|.           :|
Frog   685 -------LLAITT--ERSKSCDDG--LNTFREEGRLQRRVVG---RVPSLRM-----------LR 724

  Fly   981 NFKFFDESMDKKKYLIRMQSKPSPSGAHLASLGNELNLDEGHDKLLTSSGSSSANEPAANAASAL 1045
            :| |.|.|:|                    ||  |.| ::|..|              .::||.|
Frog   725 SF-FTDGSLD--------------------SL--EAN-EDGRSK--------------RHSASEL 751

  Fly  1046 TASTSSSTCSSGPYTEILFKTKSSNEMKRL-FGLLQWKD----------SLNYDDNEHQPQGKQL 1099
            :.:..|.....|   .:|:|...:|:.|:: .||.|||.          .|:.|    :|:.:
Frog   752 SETEFSDVRREG---WLLYKQILTNKGKKVGSGLRQWKRVFAVLRPHLLFLHKD----RPEAR-- 807

  Fly  1100 AEPQKTVASASYLDDVQGGASAADSSPLSSHSGGIADASGSH----HVSALP----AAAAIVAAT 1156
                             |.|...:..|:|. .|.:.|.|.|.    ||..|.    ......|..
Frog   808 -----------------GPAPGEEEQPISI-LGSLVDISYSETKRKHVFRLTTPDFCEYLFQAED 854

  Fly  1157 SDSISPVMKARKSSS---------------HKHIPD---------KDLGSPKSKN----WKDLLF 1193
            .|.:...:||.:.:|               :|.:.|         |...|||...    ..|||:
Frog   855 RDDMLSWVKAIRENSRMEGEDPGFASQALINKKLNDYRKVSITGVKQETSPKGSRSLGIRPDLLW 919

  Fly  1194 RRGGSGSGGVSHHDLASPSACAAKQIGSI--------------GVPLRSCPMSKVNAYVPHLVEV 1244
            ..|.|..........|...|..:|....|              ||.|..|..:..|..||.:||:
Frog   920 TSGVSAPRSPKQDGAAKEEAPPSKGAWGINLMKKNKKCPPRAFGVRLEDCQPAAENKGVPLIVEL 984

  Fly  1245 CTNIVETKGLGVVGIYRIPGNKAAISELSELVNTKDFQFESCASDDRWEDVNVVSSLLKLFIRSL 1309
            |.:.||.|||..:||||:|||.|.:|.|.|.:| |... ||...|.||:|:||||||||.|.|.|
Frog   985 CCSQVEQKGLEYLGIYRVPGNNAVVSSLQEHLN-KGLS-ESNIQDQRWQDLNVVSSLLKSFFRKL 1047

  Fly  1310 PDALMPASYYINFIEADK-KFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEP 1373
            |:.|.....|.:||||:: :...||:.:||::::.||.:.|||::.|:|||..::.:.:.|:|||
Frog  1048 PEPLFTDDKYSDFIEANRMEDSRERMKMLRKLIKELPSYYYETLRFLVRHLKTIADHSEKNKMEP 1112

  Fly  1374 KNLAIIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQYDYFFEGGSLPDIAEVSGGTAAVSAA 1438
            :|||::|||:::||..|.:...|..|..:.:|||.|:..:|:||.                 ...
Frog  1113 RNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHFDWFFS-----------------EEQ 1160

  Fly  1439 QPQQQTQEDQTSMLLHNLSKIERITERETTRTSRFMPQLRRKTHGKRSAVNSDTYSGESVLVSGS 1503
            :..::|..|:|:.  .|:..||.:           :|.:.|
Frog  1161 EKAEKTPVDETNS--QNIPNIEHL-----------LPNIGR------------------------ 1188

  Fly  1504 SSNTTTTTTTTTHTTSSTSSSNTITTTISTTTIQQRRAQRKAVQSICDQALILLLPTPVSSVSLP 1568
                    |..|...|.:::|::....:|...|..|                       ..:|:|
Frog  1189 --------TAGTGENSDSTNSDSAKGKVSRKEIYAR-----------------------DILSIP 1222

  Fly  1569 FQSLDYAKASASASAS--ASSTASTSSSSTLHSGG----KASASSSSSSTTKFSSSSSSACSTTA 1627
            |.|....|........  .|||....|.......|    ||.|......|   ..|.:..|
Frog  1223 FISAVNRKRRKRRDEKRFGSSTEEDDSEQEAARAGQVEQKAEAEVELRET---EESPAQTC---- 1280

  Fly  1628 VAISSSISATSSKLLSANFKKRSTGGFLGSRSSHQTRKASLDEKDSGQ-SSGSLGHSLGVGINLA 1691
                                           |.|......:..:::|| ..|:.....|.|
Frog  1281 -------------------------------SPHGPGAERIHSEETGQRDKGAQSRWQGSG---- 1310

  Fly  1692 KEQQRSSVDISILLTDDDSSSRLSDTGSMSLTTITDTLDSKLRNLRSGSESNDENGSPEFPKNRR 1756
              ::|..||           :|...:|..:|:|:.....|   ::|.|.|::||..  ||.....
Frog  1311 --EERIPVD-----------ARSIVSGYSTLSTLCSEPAS---SVRGGEEADDERS--EFSHMET 1357

  Fly  1757 HTLGQPLHMHSENIPYADES--PERLFHQFCNPLETAPLSLHLSRSCTATNTIGGDEKPS--KQS 1817
            .|.|.......|. |::.:|  .:||.     |.:|      |:|.......|...|:|:  :.|
Frog  1358 DTEGVGARETDER-PHSQDSFTSQRLI-----PGDT------LARRRLGRGRIESKEEPAPPRNS 1410

  Fly  1818 GGVAPLPPSLLKAAHK--------------LQHSATVPIHQGSST--------APTSGAATPVGT 1860
            ..:.|....|..||.:              .:|:..:|   |..|        .|..||.  |.:
Frog  1411 LRIRPAADDLCVAALRKPGSPETRRRKSAWRRHTVVLP---GQLTDCNFNDWKEPVPGAT--VAS 1470

  Fly  1861 PTG---SGGAGAIPSRSSSSSVTTLTKSIQPRFSNYLSYERGNAAAGGAERVVGSAG 1914
            ..|   ||||.                 ::.|.|...|.|...|....|:..:|:.|
Frog  1471 EPGSRLSGGAW-----------------VEGRDSGLSSLESQKAKTSVAQEALGNKG 1510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492	22/53 (42%)
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	86/210 (41%)
arhgap23	XP_004918722.1	PDZ_signaling	87..194	CDD:238492	50/151 (33%)
		PH	759..870	CDD:278594	28/137 (20%)
		PH_ARHGAP21-like	760..872	CDD:269955	29/138 (21%)
		RhoGAP_ARHGAP21	961..1156	CDD:239860	85/196 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	144	1.000	Domainoid score	I4569
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48922
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	1	1.000	-	-		X1550
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030