DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and bcr

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	NP_001123792.1	Gene:	bcr / 100170543	XenbaseID:	XB-GENE-980812	Length:	1162	Species:	Xenopus tropicalis

Alignment Length:	1266	Identity:	234/1266 - (18%)
Similarity:	399/1266 - (31%)	Gaps:	357/1266 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 QHQQQQQQLISYPAVAAVTTSTPAGSPQSQSQSQSHSHPNTHHAPSLHGGSRSGSITSTASGGIT 323
            |||..::.......|.  :|.....||::..:......|.. .||.|..|..:.......|  :|
Frog    79 QHQAGERDPFGEERVK--STGREERSPENSIKGPGRREPPV-GAPDLSPGDVNRGPRRLLS--LT 138

  Fly   324 VLSQPFYPQQQQQQQQQQQHRHPALTGGSSSIDFGDMA--HGLRQHQQQQ----QHLYQQQQQHH 382
            ....|    :|:..:.::...||.   ||..:....:|  .|:|......    ...|::.:.:.
Frog   139 EREDP----EQRSDRLRRASSHPE---GSPGLRGPQVAEHRGIRGRSSDSSCGWDGEYEEPELNP 196

  Fly   383 QFMRANQPPNLTVLSASSATNTPTPTARQPKSATSHNQALYAVGAGPSSAAGSGSGSLSGGSENS 447
            :|:|.|..|.                     :..:..:|.......|.|....|.|.....|.|
Frog   197 RFLRDNALPG---------------------TGGNWGEAWPRRSFSPRSFEDLGGGYTPDCSSN- 239

  Fly   448 DLMIRLRESIKQKEEFLKS----------------PVPASMSSASSINGNQAQSSSPAQQQHLQ- 495
                   |::...||.|.|                |.|.|.|..:        ..:||:|..|:
Frog   240 -------ENLTSSEEELSSGPSGRVSPRGIWSRSPPSPGSASPPT--------PQAPARQCQLRI 289

  Fly   496 --------QHQQHFFPSHTPPGGVQVVVPPPRSRHQVMLKQQQQQQQQHQQHHVLGYDMYHSGGK 552
                    :.....:||...|                                 :|.|....|..
Frog   290 AEAAIVGVRRSGQIWPSCAEP---------------------------------VGRDQGCHGDG 321

  Fly   553 LVQRSSTAPGSVCHQHQQQQQHHLY-----HQQQHQQLQQTQH--RQVMINNNAKYAK--DLDYF 608
            .......:||..   .:|:.||.|.     ......||.....  |..:.:.:.:.:|  :||..
Frog   322 DASHCRASPGGT---EEQRSQHDLMPFIDESPSSSPQLSAKSRGSRDTLSSGSLESSKSTELDLE 383

  Fly   609 ETLQ-ETGVTNKVF--ERKLVSHMSKGFDPFKPLSINTSALESSASTSSTSATTTVKKQSV---- 666
            :.|: ...|.:.:.  |...:||:.....|.|||        .:|:|:|....|..:.:::
Frog   384 KGLEMRKWVLSAILAGEETYLSHLEALLLPMKPL--------KAAATTSQPVLTVQQIETIFFKV 440

  Fly   667 --LYESLQQHPLAKYHQTQQQTTTTTTVD--GQTSSRMELHKATLANATIDPVPVGSSKFVTLPD 727
              |||..::...:.:.:.|:.:......|  .:.:|::.:::|.:.|..:
Frog   441 PELYEIHKEFYDSLFPRVQKWSHQQRVGDLFQKLASQLGVYRAFVDNYEV--------------- 490

  Fly   728 KPDKGSSVATLADIAESSAAAIVDSASGSGNV----VRRYKPLSSSSFDEG---KPMRRISYLRA 785
                      ..:.||....|....|..|.|:    .|..|..||.:..|.   ||:.|::  |:
Frog   491 ----------AMETAEKCCQANAQFAEISENLKARNTREPKDHSSKTTLEALLYKPVDRVT--RS 543

  Fly   786 TNNETDFNAEAAAGGDAAATGASGPASASAASSAPGPTPSSAPAPAPAPAPLPISIPIPVAAVVE 850
            |....|....                           ||...|           ..|:...|:..
Frog   544 TLVLHDLIKH---------------------------TPIGHP-----------DYPLLQDALRI 570

  Fly   851 PQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGLEDVRLSAHGSRRASMSSDMRSSIHIDAELN 915
            .|...|.:.|...|....:....|.|..:...:.:.::...|...|...:.:|:.....:..::.
Frog   571 SQNFLSSINEEITPRRQSMTVRKGEHRQLLKDSFMVELVEGARKLRHVFLFTDLLLCAKLKKQIG 635

  Fly   916 GK--------YVP-----------------------NELEAFETEIEIKSSCI--------NGKR 941
            ||        |:|                       :|:||.:.:|....|.|        .||.
Frog   636 GKSQQYDCKWYIPLADLNFQTVDESETASNIPMIPDDEIEAIKVKISQLKSDIQREKKAHKGGKG 700

  Fly   942 MSEYRSWRQVKLEIKGDLLRIYS--------GRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRM 998
            :...|.    ||..:..:|.:.|        .|:.||...:...|....::.:...:::|...:.
Frog   701 LERLRK----KLSEQESVLLLVSPSMAFRIQNRNGKSYTLLTWSDYERAEWAEHIREQQKKCFKS 761

  Fly   999 QSKPSPSGAHLASLGNE-LNLDEGHDKLLTSSGSSSANEPAANAASALTASTSSSTCSSGPYTEI 1062
            .|.   |...:..|.|. :.|...|...||.|.....:.......:.:..|.:....||..:..:
Frog   762 FSL---SSLEIQMLTNSCVKLQTVHRVPLTLSKEDDESSGLYGFLNVIVHSATGFQQSSNLFCTL 823

  Fly  1063 ------LFKTKSSNEMKRLFGLLQWKDSLNYDDNEHQPQGKQLAEPQKTVASASYLDDVQGGASA 1121
                  .|..|:...:.|......|.:..     |.:.:|.|      |:....|      ..|.
Frog   824 EVDSFGYFVNKAKTRVYRNTTEPNWNEEF-----EIELEGSQ------TLRILCY------EKSC 871

  Fly  1122 ADSSPLSSHSGGIAD---ASGSHHVSALPAAA-----AIVAATSDSISPVMK-ARKSSSHKHIPD 1177
            ..:.|:....|..::   |.|...:.:..|..     ::|:.....:...|| ..:..|.|.:|.
Frog   872 NRNRPMKEDGGDSSERMVAKGQVQLESQLALGKDWHRSVVSMNGIEVKLSMKFTSREFSLKRLPS 936

  Fly  1178 KDLGSPKSKNWKDLLFRRGGSGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSKVNAYVPHLV 1242
            :                                      ||.|..||.: :....:..:.||::|
Frog   937 R--------------------------------------KQTGVFGVKI-AVVTKRERSKVPYIV 962

  Fly  1243 EVCTNIVETKGLGVVGIYRIPGNKAAISELSELVNTKDFQFESCASDDRWEDVNVVSSLLKLFIR 1307
            ..|...:|.:||..|||||:.|....|..|....:..:.......||   .|||.::..|||:.|
Frog   963 RQCVEEIERRGLEEVGIYRVSGVATDIQALKNAFDANNKDVSVMMSD---MDVNAIAGTLKLYFR 1024

  Fly  1308 SLPDALMPASYYINFIEA---DKKFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDVN 1369
            .||..|.....|.||.|.   ......|..:|  .::.|||.....|...|:.||.||:.|...|
Frog  1025 ELPAPLFTDELYPNFAEGIALSDPVAKESCML--NLLLSLPEPNLLTFLFLLDHLKRVAENESQN 1087

  Fly  1370 RMEPKNLAIIFGPSIIRTPNDTLETAVKDMK 1400
            :|...|||.:|||:::| |::      ||.|
Frog  1088 KMSLHNLATVFGPTLLR-PSE------KDSK 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	58/183 (32%)
bcr	NP_001123792.1	Bcr-Abl_Oligo	3..73	CDD:312543
		SF-CC1	27..>149	CDD:273721	16/78 (21%)
		RhoGEF	392..579	CDD:366202	44/259 (17%)
		PH_BCR_vertebrate	574..767	CDD:270173	32/199 (16%)
		C2_ABR	803..924	CDD:176068	20/137 (15%)
		RhoGAP_Bcr	943..1143	CDD:239852	58/182 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030