Protein Alignment RhoGAP19D and arhgap21

DIOPT Version :9

• Sequence 1: NP_001285496.1
• Gene: RhoGAP19D / 33048
• FlyBaseID: FBgn0031118
• Length: 2206
• Species: Drosophila melanogaster
• Sequence 2: XP_031759009.1
• Gene: arhgap21 / 100037846
• XenbaseID: XB-GENE-1011028
• Length: 1952
• Species: Xenopus tropicalis
• Alignment Length: 2440
• Identity: 494/2440 - (20%)
• Similarity: 819/2440 - (33%)
• Gaps: 831/2440 - (34%)

  Fly    52 PKLIVIRRRPNQGFGFTLRHFIAYPPEDDQASSSASGLVSGSATAATAASVSTNWPQEASSAAGS 116
            ||.:.: ||.::||||||||||.||||                     ::|.|....|.:...|.
 Frog    55 PKSVAL-RRASEGFGFTLRHFIVYPPE---------------------SAVHTTVKDEENGNRGV 97

  Fly   117 NSGSSSSVGVAGITGLEPTSPTSLPPYQVKAMETIFIKEVQANGPAHYANLQTGDRVLMVNNQPI 181
            |:|.                    |..:::.|:|||:|:|:..||||.|.|.||||::.||.:.:
 Frog    98 NAGR--------------------PRNRLEPMDTIFVKQVKEGGPAHEAGLCTGDRIIKVNGESV 142

  Fly   182 AGIAYSTIVSMIKQTPAVLTLHVVPKECDVLQM-----HYTSIAHT------------------- 222
            .|..||.::::|:.:.:.|.|.|:||:.|:||:     ..|::|::
 Frog   143 IGKTYSQVIALIQNSDSTLELSVMPKDEDILQLLQFPKDVTALAYSQDAYLKGNDSYSGNAQNIP 207

  Fly   223 ------------------------PESNRLTMSTHS---------------------PS------ 236
                                    |....||....|                     ||
 Frog   208 EPPPICYPRTKPAASVMAQPVEVPPSGTSLTKQQSSRPVRTATTQPDRSYRVEIQVPPSPTDIVK 272

  Fly   237 -----LLANGSHKTT-FPAAAAV---------AAPPHQHQQQQQQLISYPAVAAVTTSTPAGSPQ 286
                 .:.|.:.:|. .|:...|         |.|.|:.::.:..|.. |::...|||.|:.:|.
 Frog   273 SNTAVCVCNEAVRTVILPSEKVVDLSSNRTNRAGPLHRTEEVRYGLAD-PSMLKRTTSPPSSTPS 336

  Fly   287 SQSQSQSHSHPNTH--HAPSLHGGSRSGSITSTASGGITVLSQPFYPQQQQQQQQQQQHRHPALT 349
            ......|....|..  ..|..:|| .|.|:.||              :..|.::......|.|..
 Frog   337 VPMVPASRQFDNAGVIGKPPSYGG-HSESMFST--------------RPSQAEESPSPTNHYASP 386

  Fly   350 GGSSSIDFGDMAHGLRQHQQQQQHLYQQQQQHHQFMRANQPPNLTVLSASSATNT------PTPT 408
            |....||:       |.::..::::..::.|.:......:  .|..|.|:|...|      |..:
 Frog   387 GSHQQIDW-------RNYKTYKEYIDNRRMQMYGCRTIQE--RLDSLRAASQNTTDYDQMLPNRS 442

  Fly   409 ARQ-PKSATSHNQALYAV------------------GAGPSSAAGSGSGSLSGG-----SENSDL 449
            :.| .:.:|||::...:|                  ...|.||:.....||:..     ||:.|.
 Frog   443 SGQVRRRSTSHDRVPQSVQMRQRSVSQERLEDPVLMKEWPRSASQDTLTSLTVAPRNHRSESWDY 507

  Fly   450 MIRLRESIKQKEEFLKSPVPASMSSASSIN----GNQAQSSSPAQQQHLQQHQQHF--------- 501
            :.|       ||:|.:..|....:.....|    |...|.......:..:||..|.
 Frog   508 LTR-------KEDFDQFIVDTQSNGEQKHNYKWTGFTEQDDQRGIYEIPRQHSFHMSLRSPNYTM 565

  Fly   502 ----FPSHTPPGGVQVVVPP-PRSRHQVMLKQQQQQQQQHQQHHVLGYDMYHSGGKLVQRSSTAP 561
                :||.:...|.:|:.|. |..:....||..|..:.                   .|.|..:|
 Frog   566 APLPYPSDSRRAGTRVLAPARPLQKVHPDLKTIQPTRN-------------------FQNSYRSP 611

  Fly   562 GSVCHQHQQQQQHHLYHQQQHQQLQ-----QTQHRQVMINNNAKYAKDLDYFETLQETGVTNKVF 621
                |......:..::...:...::     .::.....:.:.....||......:..:|..|  |
 Frog   612 ----HPRPAVSERLVFPISKSNSVKIPATYASKPYSPSVGSEDGIVKDQKAVNYIHVSGPQN--F 670

  Fly   622 ERKLVSHMSKGFDPFKPLSINTSALESSASTSSTSATTTVKKQSVLYESLQQHPLAKYHQTQQQT 686
            :||..:..:.||      .:::....:|||:||.:.|...|                  |.:..|
 Frog   671 QRKPQTESALGF------QLDSLKTSTSASSSSPAHTKPAK------------------QVKHST 711

  Fly   687 TTTTTVDGQTSSRMELHKATLANATIDPVPVGSSKFVTLPDKPDKGSSVATLADIAESSAAAIVD 751
            .|:..|||:.:...|      |||:                   ..:||.|..|
 Frog   712 ATSQNVDGKKTQSPE------ANAS-------------------DSNSVLTSID----------- 740

  Fly   752 SASGSGNVVRRYKPLSSSSFDEGKPMRRISYLRATNNETDFNAEAAAG------GDA-------- 802
                  .||.|.||  |......:|:|:.||:.|.:     :.|.|:.      .||
 Frog   741 ------QVVLREKP--SPGQQTSQPIRQPSYIFAVS-----DVEGASDTTCWLPNDARREVHIKR 792

  Fly   803 ----AATGASGPASASAA----SSAPGPTPSSAPAPAPAPAPLPISI-PIPVAAVVEPQKTK--S 856
                .|:|:..|..:.|:    .....|:.....|..||.|.:.||: |:|....|.|..|.  .
 Frog   793 IEQKKASGSDSPGDSLASIPFIDEPTSPSIDHEIANIPASAVISISVQPLPTITTVPPSPTSPVP 857

  Fly   857 LVEEHPDPTYDVIGGTGGGHEFIET----------PNGLED-------------------VRLSA 892
            |:..|....:|.|..:     .:|.          ..||:|                   .|.:.
 Frog   858 LIRRHFSHDHDSIRPS-----ILEVNSKTERSKSCDEGLDDYKDEGKLSLKQGSSLKGIKARENV 917

  Fly   893 HGSRRASMSSDMRSSIHIDAELNGKYVPNELEAFETEIEIKSSCINGKRMS-EYRSWRQVKLEIK 956
            ..|..:....|..|.:..|:...|.....:|   .||        .|||:| ..|.|:|:.:.::
 Frog   918 PSSEDSESRKDSSSDVFSDSNKEGFLYFRQL---TTE--------KGKRVSGSMRPWKQMYVVLR 971

  Fly   957 GDLLRIYSGRHAKSEHNVIELDIRNFKFFDESMDKKKYLIRMQSKPSPSGAHLASLGNELNLDEG 1021
            |..|.:...:..:|.|:..:.|
 Frog   972 GSALYLQKDKKEQSGHSSAQSD------------------------------------------- 993

  Fly  1022 HDKLLTSSG---SSSANEPAANAASALTASTSSSTCSSGPYTEILFKTKSSNEMKRLFGLLQWKD 1083
            .::|:..:|   ..|.:|........||.|.          .|.||:.:..::|......:|...
 Frog   994 EEQLIGINGCLIDISYSETKRKNVFRLTTSD----------REFLFQAEDRDDMLAWIKAIQENG 1048

  Fly  1084 SLNYDDNEHQPQ---GKQLAEPQKTVASASYLDDVQGGASAADSSPLSSHSGGIADASGSHHVSA 1145
            :||.:..:...:   .|::.|....::|:|         :.::.||..|.             ..
 Frog  1049 NLNDEQTDQASRVLISKRIKEYNTMMSSSS---------NKSEQSPKPSR-------------QT 1091

  Fly  1146 LPAAAAIVAATSDSISPVMKARKSSSHKHIPDK-DLGSPKSK-NWKDLLFRRGGSGSGGVSHHDL 1208
            |.......|...:.......:.|..|.:.:..| |:..||.| :|:.:                :
 Frog  1092 LSIRQPFRATKPEGKLQSPHSPKQESERRLFSKDDISPPKDKGSWRRI----------------M 1140

  Fly  1209 ASPSACAAKQIGSIGVPLRSCPMSKVNAYVPHLVEVCTNIVETKGLGVVGIYRIPGNKAAISELS 1273
            ..|........|:.||.|..||.:..|.|||.:|:||..:||.:||...||||:|||.||||.:.
 Frog  1141 KKPFEKKPTTGGTFGVRLDDCPPAHNNKYVPLIVDVCCKLVEDRGLETTGIYRVPGNNAAISSMQ 1205

  Fly  1274 ELVN--TKDFQFESCASDDRWEDVNVVSSLLKLFIRSLPDALMPASYYINFIEADK-KFGLERIV 1335
            |.:|  :.|...:    ||:|.|:||:|||||.|.|.|||.|.....|.:||||:: :..:||:.
 Frog  1206 EELNKGSTDIDIQ----DDKWRDLNVISSLLKSFFRKLPDPLFTNEKYNDFIEANRTEDPVERLK 1266

  Fly  1336 LLREIVESLPRHPYETMKHLIRHLCRVSGNCDVNRMEPKNLAIIFGPSIIRTPNDTLETAVKDMK 1400
            .|:.::..||.|.|||:|:|..||..|:.|.:.|:|||:||||:|||:::||..|.:...|..|.
 Frog  1267 TLKRLILDLPDHHYETLKYLSAHLKAVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMP 1331

  Fly  1401 HQCRIVELLVTQYDYFFEGGSLPDIAEVSGGTAAVSAAQPQQQTQEDQTSMLLHNLSKIERITER 1465
            .|.:|||.|:.|:|:||               :..||.:|....||:.|            :..:
 Frog  1332 DQYKIVETLIQQHDWFF---------------SEESADEPITAVQEEST------------VESQ 1369

  Fly  1466 ETTRTSRFMPQLRRKTHGKRSAVNSDTYSGESVLVSGSSSNTTTTTTTTTHTTSSTS---SSNTI 1527
            ........:|.:                 |.:.|..|..|::.:.:..:..:..|..   |...:
 Frog  1370 PVPNIDHLLPNI-----------------GRTGLSPGDVSDSASDSAKSKGSWGSGKDQYSRELL 1417

  Fly  1528 TTTISTTTIQQRRAQRKAVQSICDQALILLLPTPVSS-------------VSLPFQSLDY----- 1574
            .:::.....::|:.||..             |.|.||             :.:.||..|.
 Frog  1418 VSSLFAAASRKRKKQRDK-------------PQPSSSEDELDNVFYQKELLQVEFQRPDKQNVDK 1469

  Fly  1575 ---AKASASASASASSTASTS-------SSSTLHSGGKASASSSSSS----------------TT 1613
               .||:|.:...|.:...|:       ....:||...:......|.                ..
 Frog  1470 DVDLKANALSLKDADNIKGTNIIKEDKLEKDIMHSEATSPCPPKLSEPPIVNHRLPPDDKNIPQI 1534

  Fly  1614 KFSSSSSSACSTTAVAISSSISATSS--KLLSANFKKRSTGGFLGSRSSHQTRKASLDEKDSGQS 1676
            .|....|.:.|.|.::.||..||..|  |::|...|          .|...|...|....|...:
 Frog  1535 SFQMEESMSDSGTMLSTSSQASAQRSKPKVVSPELK----------GSDFLTADVSSITSDYSTT 1589

  Fly  1677 SGSLGHSLGVGINLAKEQQRSSVDISILLTDDDSSSRLSDTGSMSLTTITDTLDSKLRNLRSGSE 1741
            |.:: :..|:..||...:.:|..:......||:.|..:|:...|                    |
 Frog  1590 SSTI-YITGLDQNLISPEVQSVAESKGEEADDERSELISEGRPM--------------------E 1633

  Fly  1742 SNDENGSP------EFPKNRRHTLGQP---LHMHSENIPYADESPERLFHQFCNPLETAPLSLHL 1797
            ::.||..|      .|.:..|..:.:|   :.::||..|
 Frog  1634 TDSENDFPIFASSIAFDRQHRSKVEEPTRNVQVNSEGSP-------------------------- 1672

  Fly  1798 SRSCTATNTIGGDEKPSKQSGGVAPLPPSLLKAAHKLQHSATVPIHQGSSTAPTSGAATPVGTPT 1862
              |||              .|.:.|.......::|||....|:
 Frog  1673 --SCT--------------EGSITPRMDRRRFSSHKLIECDTL---------------------- 1699

  Fly  1863 GSGGAGAIPSRSSSSSVTTLTKSIQPRFSNYLSYERGNAAAGGAERVVGSAGGAASDDDSEGSTT 1927
                     ||.         |||:.:..:..|.|..|.......:.....|.:.|..|:  :|.
 Frog  1700 ---------SRK---------KSIRQKTDSECSAESKNEETLSDAQEAVKKGRSLSIGDT--TTN 1744

  Fly  1928 SDPKEKLLLGERPSPSFFIERYNKKRRDHRLFRSASFNCRNYSTRHITAQTSGGVAAGVSGGVAG 1992
            ::|:|         |::.|:  ..:|...||..||
 Frog  1745 NEPEE---------PAWRIK--ITERLKLRLKASA------------------------------ 1768

  Fly  1993 AVAVGVACCQALSTTGLTKDEKTDMNLTKKRQIQNKQNRSIKRRHTVGGPHDY---SASNGGCSN 2054
                               |:...:...|.:..:.::.::|:||||:||..|:   |..|....|
 Frog  1769 -------------------DDMFGIGSQKAQAAETRKKKNIRRRHTLGGQRDFAEISVLNAWKIN 1814

  Fly  2055 H--SHGHDLAAINYNHHNRHHQQQLLKLGSATSGGGGSGAAAAETTTTTTTTTTVL----RRLGT 2113
            .  |...:|:|::           .||....:.....|...|.|...|:|:..:::    :|:..
 Frog  1815 EPSSKEAELSAVD-----------RLKPKCPSQDLSISDWLARERLRTSTSELSMVEPEEKRISD 1868

  Fly  2114 GQAGAEASVALPASSSGSSSNNNNSPQSDGSNGNGGGVAGVASNAPPTGVGVGGNNSSGSSSNSS 2178
            ..:..|.:...|...:.|.|..:.:..:.||.....|      .|||....:.|::....:.|:.
 Frog  1869 ATSQKEPASPSPPPPASSPSQVSTAIVTAGSESPSQG------TAPPPDDQMNGDSFQSKNKNNF 1927

  Fly  2179 STSTTPAG-------NGDQVLEVGIRIKNISRGRF 2206
            |    ||.       :|.||:          |.||
 Frog  1928 S----PAVDAHPHKLSGTQVV----------RSRF 1948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492	22/53 (42%)
		RhoGAP_ARHGAP21	1221..1417	CDD:239860	90/198 (45%)
arhgap21	XP_031759009.1	PDZ_signaling	55..165	CDD:238492	49/151 (32%)
		PH_ARHGAP21-like	938..1051	CDD:269955	28/176 (16%)
		RhoGAP_ARHGAP21	1153..1348	CDD:239860	90/198 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	144	1.000	Domainoid score	I4569
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48922
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2255
SonicParanoid	1	1.000	-	-		X1550
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.940