DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RhoGAP19D and arhgap23a

DIOPT Version :9

Sequence 1:	NP_001285496.1	Gene:	RhoGAP19D / 33048	FlyBaseID:	FBgn0031118	Length:	2206	Species:	Drosophila melanogaster
Sequence 2:	XP_003198196.2	Gene:	arhgap23a / 100006233	ZFINID:	ZDB-GENE-121019-1	Length:	1845	Species:	Danio rerio

Alignment Length:	2298	Identity:	487/2298 - (21%)
Similarity:	757/2298 - (32%)	Gaps:	838/2298 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NSNGAAAAHSAASAVATPAAAASA-------AAAAAAAAVAAAANNAALAASSIQPKLIVIRRRP 61
            |.||.    ||..|::.||..:.|       ::::........:....|..|...|:.:|:::.
Zfish    65 NINGI----SAGKALSRPAQTSRAKGRRDGLSSSSENPRPVVRSGTDGLGVSWQGPRTLVLQKN- 124

  Fly    62 NQGFGFTLRHFIAYPPEDDQASSSASGLVSGSATAATAASVSTNWPQEASSAAGSNSGSSSSVGV 126
            :|||||||||||.||||                     :::.|....|.:   |:..|...|
Zfish   125 SQGFGFTLRHFIVYPPE---------------------SALHTTLKDEEN---GNGKGLQRS--- 162

  Fly   127 AGITGLEPTSPTSLPPYQVKAMETIFIKEVQANGPAHYANLQTGDRVLMVNNQPIAGIAYSTIVS 191
                .|||             |:|||:|.|:..||||.|.|.||||::.||.:.:.|..||.:::
Zfish   163 ----RLEP-------------MDTIFVKNVREKGPAHLAGLCTGDRLVKVNGESVLGKTYSQVIA 210

  Fly   192 MIKQTPAVLTLHVVPKECDVLQMHYTSIAHTPESNRLTMSTHS----PSLLANGSHKTTFPAAAA 252
            :|:.:.:||.|.::||:.||||:.|:..|:...:|..|....:    |.:|.....|:..||..:
Zfish   211 LIQNSESVLELSIMPKDEDVLQLAYSHDAYLRGNNPYTGKAQNLPPPPPVLYPPRTKSQSPAGFS 275

  Fly   253 VAAPP---HQHQQQQQQLISYPAVAA----------VTTST------------------------ 280
            ...||   |..|.|......:|..:|          |.:|.
Zfish   276 PCPPPASSHMGQNQLDNWSRWPGSSAGPSPPLDNRTVASSNVVWAAEGRNCEPGGVGHSSPAHRT 340

  Fly   281 -------------PAGSPQSQSQSQS-----------HSHPNTHHAPSL--HGGSRSGS------ 313
                         |.|..:.:|.|.|           |.|...|:..:.  |.|.|.||
Zfish   341 EEIQYGMTDRGQQPTGQMRGRSYSSSSSSGGMMSPLHHGHLANHNMGTAMGHTGGRKGSPPWASP 405

  Fly   314 --ITSTASGGIT-----VLSQPFYPQQQQQQQQQQQHR--------HPALTGGSSSIDFGDMAHG 363
              .|||.|....     .||..:|.|...:::::::.|        ||.....|.. ..|::...
Zfish   406 SQPTSTPSSSRNERTQQALSNWYYSQVPGRERERERERERSSSRSMHPRHRSFSQD-RLGELGKA 469

  Fly   364 LRQHQ---------------QQQQHLYQQQQQHHQFMRA----NQPPNLTVLSASSATNTPTPTA 409
            .|..|               ||....|.....:|...|.    .|.|::......|:.|
Zfish   470 RRSQQAGFPHSASQDTLLLLQQSAAAYADPYWNHGDWRGEHMYGQHPSVVAYGRKSSEN------ 528

  Fly   410 RQPKSATSHNQALYAVGAGPSSAAGSGSGSLSGGSENSDLMIRLRESIKQKEEFLKSPVPASMSS 474
                        |.|      |..|....||    ||.|..:.:.....::..:::.|
Zfish   529 ------------LLA------SRYGHSGRSL----ENLDRAVGILSPRVERSAWVQQP------- 564

  Fly   475 ASSINGNQAQSSSPAQQQHLQQHQQHFFPSHTPPGGVQVVVPPPRSRHQVMLKQQQQQQQQHQQH 539
                         |.:.:...:|..||                           .|..:..||.|
Zfish   565 -------------PNRTEVYARHAGHF---------------------------GQHIESPHQMH 589

  Fly   540 HVLGYDMYHSGGKLVQRSSTAPGSVCHQHQQQQQHHLY-HQQQHQQLQQTQHRQVMINNNAKYAK 603
            |.                        .||.|...|..: |..|..|.||.          |..|:
Zfish   590 HT------------------------PQHHQNLTHATHQHSSQIPQPQQA----------APMAR 620

  Fly   604 DLDYFETLQETGV----TNKVFERKL--VSHMSKGF-DP-------FKPLSINTSALES---SAS 651
            .|...::|.|..:    .:..|.||.  :...::.| ||       :.|.| .||..|.   ||:
Zfish   621 RLPSCQSLDEEPIGYRSYSPSFNRKTGRILQQAQSFRDPSYTGPHLWTPTS-KTSPPEGHPPSAT 684

  Fly   652 TS----STSATTTVKKQSVLYESLQQHPLAKYHQTQQQTTTTTTVD---GQTSSRMELHKATL-- 707
            .|    :||::||:...|               :.|.:|...|..|   |:.:|..:..:..|
Zfish   685 ASPAPPTTSSSTTISTPS---------------EGQDRTYRPTNHDRGAGEATSEAQTQEVVLRQ 734

  Fly   708 --------ANATIDP---VPVGSSK---FVTLPDKPDKGSSVATLADIAESSAAAIVDSASGSGN 758
                    |||...|   :.:.||.   |.|.|.:|                 .|..:||.....
Zfish   735 KPPTGRRGANALRHPHYAIALDSSDPLLFTTDPTEP-----------------TAKAESAISHRR 782

  Fly   759 VVRRYKPLSSSSFDEGKPMRRISYL-RATNNETDFNAEAAAGGDAAATGASGPASASAASSAPGP 822
            ......|||.    |...:..|.:: ..|:...|..|...            |||:..:|..
Zfish   783 TDVNLPPLSI----EDDSLASIPFIDEPTSPSADLRARHV------------PASSVVSSGG--- 828

  Fly   823 TPSSAPAPAPAPAPLPISIPIPVAAVVEPQKTKSLVEEHPDPTYDVIGGTGGGHEFIETPNGLED 887
             .:||||...:||....:.|:.
Zfish   829 -INSAPAVITSPASPTFTFPLN------------------------------------------- 849

  Fly   888 VRLSAHGSRRASMSSDMRSS--IHIDAELNGKYVPNELEAFETEIEIKSSCINGKRMSEYRSWRQ 950
             ||.:|..  :...|:.|||  :.|..| ..|.....|.|:..|..:.|..  .||:..:  :.:
Zfish   850 -RLFSHNC--SDPKSNRRSSYLLAITTE-RSKSCDEGLNAYREEGRVFSRL--PKRVKSF--FTE 906

  Fly   951 VKLEIKGDLLRIYSGRHAKSE-HNVIELDIR-----NFKFFDESMDKK----------------- 992
            ..|:..|......|.||:.|| .|:...|::     :||.......||
Zfish   907 GSLDSLGAAEEARSKRHSTSELGNISYSDVKREGWLHFKQIHTEKGKKVGSAIWPWRRVFSVLRT 971

  Fly   993 --KYLIRMQSKPSPSGAHLASLGNELNLDEGHDKLLTSSGSSSANEPAANAASALTASTSSST-- 1053
              .:|.:.:.:....||.|                    |..:.:|...:....|.....|.|
Zfish   972 HSLFLYKDKREAVLKGAQL--------------------GGGAEDEQPISIRGCLVDIAYSETKR 1016

  Fly  1054 -----CSSGPYTEILFKTKSSNEMKRLFGLLQW----KDSLNYDDNEHQPQGKQLAEPQKTVASA 1109
                 .::..:.|.|.:.:...:|      |:|    :|: :..|||.....:|....:|
Zfish  1017 KHALRLTTQDFCEYLLQAEDREDM------LEWIRVIRDN-SKTDNEELGFSRQALINKK----- 1069

  Fly  1110 SYLDDVQGGASAADSSPLSSHSGGIADASGSHHVSALPAAAAIVAATSDSISPVMKARKSSSHKH 1174
              |:|.:      ..||    :|...|:|...|      ....:.:..|:.:|      ..|.||
Zfish  1070 --LNDYR------KQSP----TGNKPDSSPRVH------RMTFLLSKPDNSAP------PRSPKH 1110

  Fly  1175 IPDKDLGSPKSKNWKDLLFRRGGSGSGGVSHHDLASPSACAAKQIGSIGVPLRSCPMSKVNAYVP 1239
             ..||..||....|          |...:.....|.|.|        .||.|..|..:..|.::|
Zfish  1111 -EAKDESSPPKSPW----------GINIMKKSKKAGPKA--------FGVRLEDCQPAVNNKFIP 1156

  Fly  1240 HLVEVCTNIVETKGLGVVGIYRIPGNKAAISELSELVNTKDFQFESCASDDRWEDVNVVSSLLKL 1304
            .:||:|..:||..||...||||:|||.|.:|.|.|.:| |.....  .::::|:|:||||||||.
Zfish  1157 QIVEICCGLVEDMGLEYTGIYRVPGNNAVVSSLQEQLN-KGVDIN--ITEEKWQDLNVVSSLLKS 1218

  Fly  1305 FIRSLPDALMPASYYINFIEADK-KFGLERIVLLREIVESLPRHPYETMKHLIRHLCRVSGNCDV 1368
            |.|.||:.|.....|.:||:|:: :...:|:..:::::..||.|.:.|:|.|:.||..|:.:.:.
Zfish  1219 FFRKLPEPLFTDDKYNDFIDANRMENASDRLRTMKKLIRDLPDHYFHTLKFLVGHLKTVADHSEK 1283

  Fly  1369 NRMEPKNLAIIFGPSIIRTPNDTLETAVKDMKHQCRIVELLVTQYDYFFEGGSLPDIAEVSGGTA 1433
            |:|||:|||::|||:::||..|.:...|..|..:.:|||.|:..|.:||
Zfish  1284 NKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHYTWFF---------------- 1332

  Fly  1434 AVSAAQPQQQTQEDQTSMLLHNLSKIERITERETTRTSRFMPQLRRKTHGKRSAVNSDTYSGESV 1498
                  .::|.::::
Zfish  1333 ------CEEQDKDEK-------------------------------------------------- 1341

  Fly  1499 LVSGSSSNTTTTTTTTTHTTSSTSSSNTITTTISTTTIQQRRAQRKAVQSICDQALILLLPTPVS 1563
                                          |.:.|..:|                     |.|
Zfish  1342 ------------------------------TPVDTEDVQ---------------------PAP-- 1353

  Fly  1564 SVSLPFQSLDYAKASASASASASSTASTSSSSTLHSGGKASASSSSSSTTKFSSSSSSACSTTAV 1628
                   ::|:..::...:...               |:||.|::|.|.....|..|....|...
Zfish  1354 -------NIDHLLSNIGRTGML---------------GEASDSTNSDSAKSKGSWGSKRDFTAKD 1396

  Fly  1629 AISSSI-SATSSKLLSANFKKRSTGGFLGSR----SSHQTRKASLDEKDSGQSSGSLG------- 1681
            .::.|| ||.:.|.     :||..|..|||.    |.|:..|:.:.|||..|..|.:.
Zfish  1397 ILTLSIMSAVTRKR-----RKRHNGRLLGSSTDDDSEHEPIKSCISEKDDLQEMGQVASFCAPRA 1456

  Fly  1682 ---------------HSLGVGINLAKEQQRS---------SVDISILLTDDDS---------SSR 1713
                           ...|.....|:||:.:         .|..::||::::.         |.|
Zfish  1457 EGEEDDDEEEEDDEEEEEGAERQKAQEQKETVVPSISSTEEVTSTVLLSEEEEQKSEVKGGRSWR 1521

  Fly  1714 LSD-----TGSMSLTTITDTLDSKLRNLRSGSESNDENGSPEFPKNRRHTLGQPLHMHSENIPYA 1773
            |.|     :|..:|:|:..:|.|:.|    |.:::||                    |||.:...
Zfish  1522 LDDARSIVSGYSTLSTLGRSLASEGR----GEDADDE--------------------HSELVSET 1562

  Fly  1774 DESPERLFHQFCNPLETAPLSLHLSRSCTATNTIGGDEKP--SKQSGGVAPLP--PSLLKAAHKL 1834
            |..                 |...|||.|...    .|||  |.|:...:|.|  |.....||
Zfish  1563 DNE-----------------SGFASRSLTQER----PEKPNRSNQNSHASPEPTAPQSFLYAH-- 1604

  Fly  1835 QHSATVPIHQGSSTAPTSGAATPVGTPTGSGGAGAIPSRSSSSSVTTLTKSIQPRFSN--YLSYE 1897
               ...|...||:|||:..:......|..|....:.||.||.||      |...|..|  :.|:.
Zfish  1605 ---CKSPTPSGSATAPSPPSQHITTNPEDSAARSSTPSTSSYSS------SASQRLHNRSFNSHR 1660

  Fly  1898 RGNAAAGGAERVVGSAGGAASDDDSEGSTTSDPKEKLLLG------ERPSPSFFIERYNKKRRDH 1956
            ..........|.......|.|.|.||.|::|..:|....|      ..||||
Zfish  1661 LIQCDTLARRRTKADKAKAPSVDLSELSSSSAAEEDRQSGANQIPDSSPSPS------------- 1712

  Fly  1957 RLFRSASFNCRNYST--RHITAQTSGGVAAGVSGGVAGAV---AVGVACCQALSTTGLTKDEKTD 2016
              .::..|:.||..|  ..:...:.|.|.:...|.:|..|   .:|.|            |:...
Zfish  1713 --SKAKGFSIRNECTPISMVGPGSKGCVLSPGQGSLADQVRARLMGSA------------DDLCS 1763

  Fly  2017 MNLTKKRQIQNKQNRSIKRRHTV 2039
            :.|.|:...:.::.|...|||||
Zfish  1764 VGLRKQLSPETRRKRRAWRRHTV 1786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP19D	NP_001285496.1	PDZ_signaling	<151..205	CDD:238492	23/53 (43%)
RhoGAP19D	NP_001285496.1	RhoGAP_ARHGAP21	1221..1417	CDD:239860	75/196 (38%)
arhgap23a	XP_003198196.2	PDZ_signaling	116..223	CDD:238492	50/151 (33%)
		PH	936..1052	CDD:278594	19/142 (13%)
		PH_ARHGAP21-like	938..1054	CDD:269955	19/142 (13%)
		RhoGAP_ARHGAP21	1138..1332	CDD:239860	76/204 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575250
Domainoid	1	1.000	151	1.000	Domainoid score	I4310
eggNOG	1	0.900	-	-		E1_KOG4407
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	315	1.000	Inparanoid score	I2535
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24838
orthoMCL	1	0.900	-	-		OOG6_104725
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1550
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690