DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GstT3 and RABGAP1L

DIOPT Version :9

Sequence 1:	NP_001162808.1	Gene:	GstT3 / 33047	FlyBaseID:	FBgn0031117	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_001353375.1	Gene:	RABGAP1L / 9910	HGNCID:	24663	Length:	1051	Species:	Homo sapiens

Alignment Length:	286	Identity:	58/286 - (20%)
Similarity:	105/286 - (36%)	Gaps:	73/286 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVSFLASLLGL-SNDEDQLQVAFDEVLKRRVPSRQPTNLRMSAPIRYYYD-----LMSQ----- 54
            :::.|..:|..| ::.||.||..|:..||         ..|:..|.||..:     ||.|
Human   725 LNIIFHVALALLKTSKEDLLQADFEGALK---------FFRVQLPKRYRAEENARRLMEQACNIK 780

  Fly    55 -PSRALFIIFRLSNMPFEDCVVALRNGEHLTED----FKKEINRFQ----RVPCIHDN-GYKLAE 109
             |::.|        ..:|.....:|..:...||    :|:|..|.|    |:...:|: .::|..
Human   781 VPTKKL--------KKYEKEYQTMRESQLQQEDPMDRYKRENRRLQEASMRLEQENDDLAHELVT 837

  Fly   110 SVAILRYLSAKGKIPEHLYPKYFVDQSRVDEFLEWQHMSLRLTCAMYFRTVWLEPLLTGRTPSEA 174
            |...||.                 |..:.::..:..:..|.||..   |.|..|.....:....|
Human   838 SKIALRN-----------------DLDQAEDKADVLNKELLLTKQ---RLVETEEEKRKQEEETA 882

  Fly   175 KI-ETFRMQMERNLDVVEEVWLEGKDFLTGSSLTVADIFAACEIEQTRMADYDVRIKYPKIRAWL 238
            :: |.||.|:|:....:::           ::..:|:....|....||:.......| .::.. :
Human   883 QLKEVFRKQLEKAEYEIKK-----------TTAIIAEYKQICSQLSTRLEKQQAASK-EELEV-V 934

  Fly   239 KRVRQSCNPYYDV-AHEFVYKISGTG 263
            |....:|....|: :.|...|::.||
Human   935 KGKMMACKHCSDIFSKEGALKLAATG 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GstT3	NP_001162808.1	GST_N_Theta	45..121	CDD:239348	21/95 (22%)
		GstA	47..243	CDD:223698	39/216 (18%)
		GST_C_Theta	135..259	CDD:198292	21/125 (17%)
RABGAP1L	NP_001353375.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		PTB_Rab6GAP	129..257	CDD:269922
		DUF3694	290..421	CDD:315198
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..503
		RabGAP-TBC	541..744	CDD:306939	5/18 (28%)
		DUF3084	800..>1018	CDD:331293	37/194 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900