DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GstT3 and TBC1D8B

DIOPT Version :9

Sequence 1:	NP_001162808.1	Gene:	GstT3 / 33047	FlyBaseID:	FBgn0031117	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_060222.2	Gene:	TBC1D8B / 54885	HGNCID:	24715	Length:	1120	Species:	Homo sapiens

Alignment Length:	298	Identity:	52/298 - (17%)
Similarity:	96/298 - (32%)	Gaps:	120/298 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVSFLASLLGLSNDEDQLQVAFDEVLKRRVPSRQPTNLRMSAPI-------RYYYDLMSQPSRA 58
            :|.:||:....|...|.:|.:::|||.|    ..:.:|:.::..|       .:|:.:....::.
Human   180 LSTNFLSFYSFLLGSEIKLIISWDEVSK----LEKTSNVILTESIHVCSQGENHYFSMFLHINQT 240

  Fly    59 LFIIFRLSNM-------------------PFEDCVVALRNGEHLTEDFKKEINRFQRVP------ 98
            ..::.:|:|.                   |.:.....|.|..|     .::.|.|.|:|
Human   241 YLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAH-----SEQFNAFFRLPKGESLK 300

  Fly    99 --------------------CIHDNGY---------------KLAESVAILR--------YLSAK 120
                                ||.:| |               .|.|.:||.:        .:|.|
Human   301 EVHECFLWVPFSHFNTHGKMCISEN-YICFASQDGNQCSVIIPLREVLAIDKTNDSSKSVIISIK 364

  Fly   121 GKIP---------EHLYPKYFV--------------------DQSRVDEFLEWQHMSLRLTCAMY 156
            ||..         |.|..|..:                    :.:...:..|.|.::.:..|:
Human   365 GKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDNFEVQSLTSQRECS-- 427

  Fly   157 FRTVWLEPLLTGRTPSEAKIETFRMQMERNLDVVEEVW 194
             :||..|.|:|...|.  .:||...:|.:. .:.|:.|
Human   428 -KTVNTEALMTVFHPQ--NLETLNSKMLKE-KMKEQSW 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GstT3	NP_001162808.1	GST_N_Theta	45..121	CDD:239348	21/150 (14%)
		GstA	47..243	CDD:223698	40/245 (16%)
		GST_C_Theta	135..259	CDD:198292	14/60 (23%)
TBC1D8B	NP_060222.2	PH-GRAM1_TBC1D8B	156..254	CDD:275419	15/77 (19%)
		PH-GRAM2_TBC1D8B	296..388	CDD:270159	15/92 (16%)
		TBC	486..694	CDD:214540
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1035..1066
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900