DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GstT3 and MARS1

DIOPT Version :9

Sequence 1:	NP_001162808.1	Gene:	GstT3 / 33047	FlyBaseID:	FBgn0031117	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_004981.2	Gene:	MARS1 / 4141	HGNCID:	6898	Length:	900	Species:	Homo sapiens

Alignment Length:	156	Identity:	37/156 - (23%)
Similarity:	62/156 - (39%)	Gaps:	48/156 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LSNMPFEDCVVALRNGEHLTEDFKKEINRFQRVPCIH-DNGYKLAESVAILRYLSAKGKIPEHLY 128
            :|.:..|||||..     ||.         .:||.:. |:|..|..:.||.||
Human    30 ISTVGPEDCVVPF-----LTR---------PKVPVLQLDSGNYLFSTSAICRY------------ 68

  Fly   129 PKYFV-----DQSRVDEFLEWQHMSLR--LTCAMYFRTVWLEPLLTGRTPSEAKIETFRMQMERN 186
              :|:     .....:::|||:...|:  |:.|:|:..|      .|:     |.|.....:.|.
Human    69 --FFLLSGWEQDDLTNQWLEWEATELQPALSAALYYLVV------QGK-----KGEDVLGSVRRA 120

  Fly   187 LDVVE-EVWLEGKDFLTGSSLTVADI 211
            |..:: .:..:...||.|.:.::|||
Human   121 LTHIDHSLSRQNCPFLAGETESLADI 146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GstT3	NP_001162808.1	GST_N_Theta	45..121	CDD:239348	17/56 (30%)
		GstA	47..243	CDD:223698	37/156 (24%)
		GST_C_Theta	135..259	CDD:198292	19/80 (24%)
MARS1	NP_004981.2	Thioredoxin_like	<27..68	CDD:294274	15/51 (29%)
		GstA	<47..189	CDD:223698	29/125 (23%)
		GST_C_MetRS_N	77..179	CDD:198340	19/81 (23%)
		PRK12268	264..819	CDD:237029
		MetRS_core	265..633	CDD:173907
		'HIGH' region	273..283
		'KMSKS' region	593..597
		Anticodon_Ia_Met	642..771	CDD:153411
		MetRS_RNA	845..889	CDD:238475
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0625
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900