DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GstT3 and RABGAP1

DIOPT Version :9

Sequence 1:	NP_001162808.1	Gene:	GstT3 / 33047	FlyBaseID:	FBgn0031117	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_036329.3	Gene:	RABGAP1 / 23637	HGNCID:	17155	Length:	1069	Species:	Homo sapiens

Alignment Length:	288	Identity:	57/288 - (19%)
Similarity:	98/288 - (34%)	Gaps:	110/288 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SFLASLLGLSNDEDQLQVAFDEVLKRRVPSRQPTNLRMSAPIRYYYDLMSQPSRALFIIFRLSNM 68
            ||||::|.|...|:|   ||..::|                |.:.|.|     |.||      ..
Human   652 SFLAAVLLLHMPEEQ---AFSVLVK----------------IMFDYGL-----RELF------KQ 686

  Fly    69 PFEDCVVALRNGEHLTEDFKKEINRFQRVPCIHDNGYKLA------ESVAILRYLSAKGKIPEHL 127
            .|||........|.|.:::         :|.::::...::      .|...|...:||
Human   687 NFEDLHCKFYQLERLMQEY---------IPDLYNHFLDISLEAHMYASQWFLTLFTAK------- 735

  Fly   128 YPKYFVDQSRVDEFLEWQHMSLRLTCAMYFRTVWLEPLLTGRTPSEAKIETFRMQM------ERN 186
            :|.|.|  ..:.:.|..:.:|:....|:.......:.||.  |..|..::.||:|:      |.|
Human   736 FPLYMV--FHIIDLLLCEGISVIFNVALGLLKTSKDDLLL--TDFEGALKFFRVQLPKRYRSEEN 796

  Fly   187 LDVVEEVWLEGKDFLTGSSLTVADIFAAC--EIEQTRMADYDVRIKYPKIRAWLKRVRQSCNPYY 249
            ...:.|:                    ||  :|.|.::..|:.  :|..:|   ::..|..:|..
Human   797 AKKLMEL--------------------ACNMKISQKKLKKYEK--EYHTMR---EQQAQQEDPIE 836

  Fly   250 ---------------------DVAHEFV 256
                                 |:|||.|
Human   837 RFERENRRLQEANMRLEQENDDLAHELV 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GstT3	NP_001162808.1	GST_N_Theta	45..121	CDD:239348	15/81 (19%)
		GstA	47..243	CDD:223698	38/209 (18%)
		GST_C_Theta	135..259	CDD:198292	27/151 (18%)
RABGAP1	NP_036329.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79
		PTB_Rab6GAP	145..273	CDD:269922
		DUF3694	307..437	CDD:403614
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..527
		TBC	563..772	CDD:214540	33/167 (20%)
		Smc	<823..>1047	CDD:224117	8/45 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900