DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GstT3 and TBC1D2B

DIOPT Version :9

Sequence 1:	NP_001162808.1	Gene:	GstT3 / 33047	FlyBaseID:	FBgn0031117	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	NP_001374071.1	Gene:	TBC1D2B / 23102	HGNCID:	29183	Length:	974	Species:	Homo sapiens

Alignment Length:	176	Identity:	34/176 - (19%)
Similarity:	61/176 - (34%)	Gaps:	50/176 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 RYYYDLMSQPSRAL------------FIIFRLSNMPFEDCVVA----------LRNGEHLTEDFK 88
            |.:.||||:....|            .|.|....:.|.|.||:          |..|..:...|.
Human   800 RVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFA 864

  Fly    89 KEINRFQRVPCIHDNGYKLAESVAILRYLSAKGKIPEHLYPKYFVDQSRVDEFLEWQHMSLRLTC 153
            ..:.:::....:     ||.:|::|.:||            :||....          :..|...
Human   865 LALFKYKEEEIL-----KLQDSMSIFKYL------------RYFTRTI----------LDARKLI 902

  Fly   154 AMYFRTVWLEPLLTGRTPSEAKIETFRMQMERNLDVVEEVWLEGKD 199
            ::.|..:...||...|......:|..|::: ..|:.:.|.:|..:|
Human   903 SISFGDLNPFPLRQIRNRRAYHLEKVRLEL-TELEAIREDFLRERD 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GstT3	NP_001162808.1	GST_N_Theta	45..121	CDD:239348	21/96 (22%)
		GstA	47..243	CDD:223698	33/175 (19%)
		GST_C_Theta	135..259	CDD:198292	11/65 (17%)
TBC1D2B	NP_001374071.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		PH_TBC1D2A	36..144	CDD:269966
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	272..348
		Smc	<338..552	CDD:224117
		RabGAP-TBC	665..876	CDD:366170	15/75 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900