DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GstT3 and TBC1D8

DIOPT Version :9

Sequence 1:	NP_001162808.1	Gene:	GstT3 / 33047	FlyBaseID:	FBgn0031117	Length:	268	Species:	Drosophila melanogaster
Sequence 2:	XP_005263919.1	Gene:	TBC1D8 / 11138	HGNCID:	17791	Length:	1162	Species:	Homo sapiens

Alignment Length:	210	Identity:	41/210 - (19%)
Similarity:	76/210 - (36%)	Gaps:	48/210 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 ALFIIFRLSNMPFEDCVVALRNGEHLTEDFKKEINRFQRVPCIHDNGYKLAESVAILRYLSA--- 119
            |.|:..::..:..|:....|...|...|.|::.:.:|:.       .:...|:..::.|.|.
Human   133 ASFVKGKVKALIAEETSSRLAEQEEEPEKFREALVKFEA-------RFNFPEAEKLVTYYSCCCW 190

  Fly   120 KGKIPEHLYPKYFVDQSRVDEFLEWQHMSLRLTCAMYF------RTV--WLEPLLTGRTPSEAKI 176
            ||::|..                .|.::|:...|...|      :.|  |::.....||.:....
Human   191 KGRVPRQ----------------GWLYLSINHLCFYSFFLGKELKLVVPWVDIQKLERTSNVFLT 239

  Fly   177 ETFRM---------QMERNLDVVEEVWLEGKDFLTGSSLTVADIF----AACEIEQTRMADYDVR 228
            :|.|:         .|..|||.|.:|..:..| :|...|...::|    ...|..|....|.:.|
Human   240 DTIRITTQNKERDFSMFLNLDEVFKVMEQLAD-VTLRRLLDNEVFDLDPDLQEPSQITKRDLEAR 303

  Fly   229 IKYPKIRAWLKRVRQ 243
            .:....||:.:..|:
Human   304 AQNEFFRAFFRLPRK 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GstT3	NP_001162808.1	GST_N_Theta	45..121	CDD:239348	11/65 (17%)
		GstA	47..243	CDD:223698	40/208 (19%)
		GST_C_Theta	135..259	CDD:198292	27/130 (21%)
TBC1D8	XP_005263919.1	PH-GRAM1_TBC1D8	178..276	CDD:270156	23/114 (20%)
		PH-GRAM2_TBC1D8	318..413	CDD:270160	0/1 (0%)
		TBC	527..733	CDD:214540
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900