DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1695 and RABGAP1L

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001353375.1	Gene:	RABGAP1L / 9910	HGNCID:	24663	Length:	1051	Species:	Homo sapiens

Alignment Length:	819	Identity:	152/819 - (18%)
Similarity:	290/819 - (35%)	Gaps:	254/819 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   420 FLSCLETGLLPHGQLDPPLWSQRGIGKL-----FPWPKSVRRHILPSVMEAGGSVTDETPIDYVF 479
            :|.|::.. .|..:::    :.|.:..:     :|:|.::   .:|:|.|  |||
Human   136 YLGCMKVS-SPRNEVE----ALRAMATMKSSSQYPFPVTL---YVPNVPE--GSV---------- 180

  Fly   480 RVVSKCQHEEFLASHPILELGRSSPRRKHLG----SCSTTGSSDCSSKSLSIDQSSCETPLIQAS 540
            |::.:..:.| :||.||.::...:  |.|.|    :|.....|...|:...|...|||.
Human   181 RIIDQSSNVE-IASFPIYKVLFCA--RGHDGTTESNCFAFTESSHGSEEFQIHVFSCEI------ 236

  Fly   541 QSTSIELVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVNGRIMPDLAADEEGLTRGKWLAM 605
                         ::.:||..|   ::|.........:|. |...::|  ..|.:..|....|.:
Human   237 -------------KEAVSRILY---SFCTAFKRSSRQVSD-VKDSVIP--TPDSDVFTFSVSLEV 282

  Fly   606 HEDGVVTGDLELYRLVYFGGVEPELRKEVWPYLLGHYDFGSTPEERKKQDETCKHYYETTMSEWL 670
            .||.                              |..:|...|::|.      |.|::
Human   283 KEDD------------------------------GKGNFSPVPKDRD------KFYFK------- 304

  Fly   671 AVEAIVRQREKEKTALAVAKLSAEQARLAANATSSSNPHQKLANGSQQLQLEHGNGEEDQENLVL 735
                 ::|..::|..:.|.:||                       :::|.:|...|      ::|
Human   305 -----LKQGIEKKVVITVQQLS-----------------------NKELAIERCFG------MLL 335

  Fly   736 DEGENDVFDDNDFSDISDPGDLFDEPELGQEAEEQEQSNLEEEVFEKQEDEEDQEDHDQREMPRL 800
            ..|.|....|....|:...|..:|    |:........|....||....:|..::  .|..|...
Human   336 SPGRNVKNSDMHLLDMESMGKSYD----GRAYVITGMWNPNAPVFLALNEETPKD--KQVYMTVA 394

  Fly   801 SEKLVLEFQNIDNMEPLRLQENCFADSETENDLGLGLDSSGNILMLSIKSSPSTSSYETVGNE-F 864
            .:.:|.|.     :||:|.                       :|...::..|:...:.....: |
Human   395 VDMVVTEV-----VEPVRF-----------------------LLETVVRVYPANERFWYFSRKTF 431

  Fly   865 LDMAEAKLEEEEPPGQLSKFHSADDVRLDNQDEEESSQPATAVIITEAASLDALDDDPTEEFTSR 929
            .:....:|::.|..|..:...:..:| :..|.|.:..:|.|..  :....:...||:..||..:.
Human   432 TETFFMRLKQSEGKGHTNAGDAIYEV-VSLQRESDKEEPVTPT--SGGGPMSPQDDEAEEESDNE 493

  Fly   930 KTSLMSPLNEDITVV-------------ASLDALQEPKSACVS---PASSNGGVYSV-------- 970
            .:|....:::|....             ::|.|..:..|..|.   |.:....|:.:
Human   494 LSSGTGDVSKDCPEKILYSWGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQ 558

  Fly   971 ELLEQFGLNLHR-------IEKDVQRCDRNYWYF------ANENLDKLRNVISTYVWEHLDVGYM 1022
            .:|:::.:.:.:       |.:|:.|....:.||      ..|:|.|:....|.|   ..|:||.
Human   559 AMLDRYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVY---DEDIGYC 620

  Fly  1023 QGMCDLVAPLLVIFDDESLSYSCFCKLMERMIE---------NFPSGGAMDMHFANMRSLIQILD 1078
            ||...|.|.||:...:|    ..||.|::.|.:         ||.     |:| .....|.:::.
Human   621 QGQSFLAAVLLLHMPEE----QAFCVLVKIMYDYGLRDLYRNNFE-----DLH-CKFYQLERLMQ 675

  Fly  1079 SEMYDLMDSNGDYTHF--------YFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF 1135
            .::.||      ::||        .:..:|||..|..:.....||...:::     :..|..::|
Human   676 EQLPDL------HSHFSDLNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLL-----LCEGLNIIF 729

  Fly  1136 -LALALLETYRDIILSNSMDFTDVIKFFN-EMAERHNAQ 1172
             :|||||:|.::.:|  ..||...:|||. ::.:|:.|:
Human   730 HVALALLKTSKEDLL--QADFEGALKFFRVQLPKRYRAE 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431	13/69 (19%)
		SRP68-RBD	<648..>713	CDD:304552	9/64 (14%)
		TBC	947..1124	CDD:214540	46/217 (21%)
RABGAP1L	NP_001353375.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		PTB_Rab6GAP	129..257	CDD:269922	32/165 (19%)
		DUF3694	290..421	CDD:315198	34/211 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..503		9/43 (21%)
		RabGAP-TBC	541..744	CDD:306939	49/226 (22%)
		DUF3084	800..>1018	CDD:331293
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810