Protein Alignment CG1695 and SGSM2

DIOPT Version :10

• Sequence 1: NP_728346.2
• Gene: CG1695 / 33046
• FlyBaseID: FBgn0031116
• Length: 1192
• Species: Drosophila melanogaster
• Sequence 2: XP_011522403.1
• Gene: SGSM2 / 9905
• HGNCID: 29026
• Length: 1103
• Species: Homo sapiens
• Alignment Length: 1275
• Identity: 534/1275 - (41%)
• Similarity: 688/1275 - (53%)
• Gaps: 305/1275 - (23%)

  Fly    22 VSNAETELKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLC--------------------- 65
            :.:||..:||:|:.:|||||||:||||||:|:|||:||.:.:||
Human     1 MGSAEDAVKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCAADPHQGLTRCQTPFTVQGNG 65

  Fly    66 -------------------------GAVEACLSHGLRRRALGLFKTSSTTALIQKIAKICPEADY 105
                                     .||||||.|.|||||.|..::....||..|:.|.||.|..
Human    66 SDKMDRVSAAGAYILLGRQTGNKCASAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGE 130

  Fly   106 VSRRLLELELAQESHAVSGKRSSCSSDSIIKPKLLSKGSGSSNSVTTINTVTNGAGAGPGGGGGA 170
            :..::.||:...|....||         :.:..|..:||.|              |..|     |
Human   131 ICHKVQELQQQAEGRKPSG---------VSQEALRRQGSAS--------------GKAP-----A 167

  Fly   171 SAPLG-KYLWIRLALHEKRLAKIIEHLVSNANSYYDREALVADPDYGSILSSLLVGPCALEFTRA 234
            .:|.. |::|:|.||.||.|.|::::|..|.:.||::|||:|||.:|.||:||||||||||:|:.
Human   168 LSPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKL 232

  Fly   235 KTADHYWSDPCADELVQRHRISSGNRTPPT-----THRPIINFKRSLHTSSEDTSSGSFKACSPA 294
            |||||||:||.||||||||||    |.|||     ..||.:.. |..|      ||||......|
Human   233 KTADHYWTDPSADELVQRHRI----RGPPTRQDSPAKRPALGI-RKRH------SSGSASEDRLA 286

  Fly   295 SVAKDYVESLHQNSRTTLLYGKNNVLVLPKDVSEPMPGYLSLHQSIQSLTIKWTPNQLMNGYNDG 359
            :.|::.||||||||||.||||||:|||.||:..|.:|||||||||.:|||:||||||||||....
Human   287 ACARECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTLGD 351

  Fly   360 DGGDKSFYWSYALNINVDEIVYVHCHQNRGGDTGGTIILVGQDGVQRPPIHFPEGGHLQAFLSCL 424
            ...:||.||.|||.:...::|.:||||.:   :|||::||.|||:||||:|||:||||.:|||||
Human   352 SELEKSVYWDYALVVPFSQVVCIHCHQQK---SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCL 413

  Fly   425 ETGLLPHGQLDPPLWSQRGIGKLFPWPKSVRRHILPSV-MEAGGSVTDETPIDYVFRVV---SKC 485
            |.||||.|||:||||:|:|.||:|  ||..:|..:.|| ||..|:   ....|||||::   .:.
Human   414 ENGLLPRGQLEPPLWTQQGKGKVF--PKLRKRSSIRSVDMEEMGT---GRATDYVFRIIYPGHRH 473

  Fly   486 QH--------------------EEFLASHPILEL------------------------GRSSPRR 506
            :|                    ||....|.:|.:                        |.|.| .
Human   474 EHITINYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMKDAGDMIEMQGFGPSLP-A 537

  Fly   507 KHLGSCSTTGSS--DCSSKS---LSIDQSSC---ETPLIQASQSTSIELVCSTMRRQIISRAFYG 563
            .||....:.|||  .|||.|   .:....||   ..||         .|:|.:|:|||:||||||
Human   538 WHLEPLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPL---------RLLCESMKRQIVSRAFYG 593

  Fly   564 WLAYCRHLSTVRTHLSGLVNGRIMPD--LAADEEGLTRGKWLAMHEDGVVTGDLELYRLVYFGGV 626
            |||:||||||||||||.||:..::|.  ......|||:..|....:|.....:|||.|.||:||:
Human   594 WLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKELELLRQVYYGGI 658

  Fly   627 EPELRKEVWPYLLGHYDFGSTPEERKKQDETCKHYYETTMSEWLAVEAIVRQREKEKTALAVAKL 691
            |.|:||:|||:|||||.||.:.:|.::.|......|:..::||.|.|.:|||||:|.......|.
Human   659 EHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEVVVRQREREAHPATRTKF 723

  Fly   692 SAEQARLAANATSSSNPH-QKLANGSQQLQLEHGNGEEDQENLVLDEGENDVF---DDNDFSDIS 752
            |         :.||.:.| |:|.:....:                   .||||   ||.:..:..
Human   724 S---------SGSSIDSHVQRLIHRDSTI-------------------SNDVFISVDDLEPPEPQ 760

  Fly   753 DPGDLFDEPELGQEAEEQEQSNLEEEVFEKQEDEEDQEDHDQREMPRLSEKLVLEFQNIDNMEPL 817
            ||.|...:||  |||.......   .|.|:|..                    :||.:.|:
Human   761 DPEDSRPKPE--QEAGPGTPGT---AVVEQQHS--------------------VEFDSPDS---- 796

  Fly   818 RLQENCFADSETENDLGLGLDSSGNILMLS-IKSSPSTSSYETVGNEFLDMAEAKLEEEEPPGQL 881
                              ||.||.|..:.| |:||             ||..::...|||
Human   797 ------------------GLPSSRNYSVASGIQSS-------------LDEGQSVGFEEE----- 825

  Fly   882 SKFHSADDVRLDNQDEEESSQPATAVIITEAASLDALDDDPTEEFTSRKTSLMSPLNEDITVVAS 946
                       |...||.||.|..|     |.:|.. ..||::|...               ...
Human   826 -----------DGGGEEGSSGPGPA-----AHTLRE-PQDPSQEKPQ---------------AGE 858

  Fly   947 LDALQEPKSACVSPASSNGGVYSVELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDKLRNVIST 1011
            |:|.:|..:.|.:       .|::|||:...||||||:|||||||||||||...||::||:|:.:
Human   859 LEAGEELAAVCAA-------AYTIELLDTVALNLHRIDKDVQRCDRNYWYFTPPNLERLRDVMCS 916

  Fly  1012 YVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQI 1076
            ||||||||||:||||||:|||||..|::.|:||||..||:||.:|||:|||||.|||||||||||
Human   917 YVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQI 981

  Fly  1077 LDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALL 1141
            ||||:::||..||||||||||||||||||||||:|:||||.|||||||:||:|.|||||:||||:
Human   982 LDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALV 1046

  Fly  1142 ETYRDIILSNSMDFTDVIKFFNEM-AERHNAQSILQLSRS 1180
            |.||:||..|:|||||:|||||.: ....|..||....||
Human  1047 EAYREIIRDNNMDFTDIIKFFNALHVSPQNVLSITMPRRS 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN_SGSM1_like	39..233	CDD:439049	84/240 (35%)
		PH_RUTBC	310..485	CDD:275431	101/178 (57%)
		TBC	947..1124	CDD:214540	120/176 (68%)
SGSM2	XP_011522403.1	RUN	18..243	CDD:459241	93/252 (37%)
		PH_RUTBC	302..470	CDD:275431	101/175 (58%)
		TBC	<885..1053	CDD:214540	127/167 (76%)