DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1695 and USP6NL

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	XP_006717605.1	Gene:	USP6NL / 9712	HGNCID:	16858	Length:	856	Species:	Homo sapiens

Alignment Length:	198	Identity:	45/198 - (22%)
Similarity:	88/198 - (44%)	Gaps:	24/198 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   979 NLHRIEKDVQRCDRNYWYFANE---NLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDES 1040
            ::.:|:.||.|..|::..|.:.   ....|.:|::.|...:.:|||.|||..:.|.||:..::|.
Human   168 DIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEED 232

  Fly  1041 LSYSCFCKLMER--------MIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFC 1097
             ::....||...        .::.||.......|.   ..::....|::...:||...||.|| .
Human   233 -AFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHH---EKILNKFLSKLKQHLDSQEIYTSFY-T 292

  Fly  1098 YRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVL-FLALALLETYRDIILSNSMDFTDVIKF 1161
            .:||...|.....:......|::     :|..|..|| .::..:|:.::..::..||:  ::::|
Human   293 MKWFFQCFLDRTPFTLNLRIWDI-----YIFEGERVLTAMSYTILKLHKKHLMKLSME--ELVEF 350

  Fly  1162 FNE 1164
            |.|
Human   351 FQE 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552
		TBC	947..1124	CDD:214540	35/155 (23%)
USP6NL	XP_006717605.1	TBC	125..340	CDD:214540	40/181 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900