DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1695 and TBC1D10A

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001191169.1	Gene:	TBC1D10A / 83874	HGNCID:	23609	Length:	515	Species:	Homo sapiens

Alignment Length:	175	Identity:	36/175 - (20%)
Similarity:	66/175 - (37%)	Gaps:	31/175 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   983 IEKDVQRCDRNYWYFAN---ENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYS 1044
            ||:|:.|....:..|.:   .....|..|:..|.....:.||.|....:.|.||:....|. ::.
Human   161 IERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQ-AFW 224

  Fly  1045 CFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSE-MYDLMDSNGDYTH----------FYFCY 1098
            |..::.|:.:..:         ::.....|| ||.| ::.|:.......|          ..:..
Human   225 CLVQICEKYLPGY---------YSEKLEAIQ-LDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMT 279

  Fly  1099 RWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLE 1142
            .||:..|.|.|.:..|...|::.:     ..|..::| :.|.||:
Human   280 EWFMCAFSRTLPWSSVLRVWDMFF-----CEGVKIIFRVGLVLLK 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552
		TBC	947..1124	CDD:214540	31/154 (20%)
TBC1D10A	NP_001191169.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		TBC	117..320	CDD:214540	36/175 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	403..515
		ZipA	<403..>502	CDD:331990
		Binding to the PDZ domain of EBP50	512..515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900