DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1695 and GRTP1

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001273661.1	Gene:	GRTP1 / 79774	HGNCID:	20310	Length:	344	Species:	Homo sapiens

Alignment Length:	248	Identity:	55/248 - (22%)
Similarity:	103/248 - (41%)	Gaps:	34/248 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   955 SACVSPASSNGGVYSVELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDK---------LRNVIS 1010
            |...:....|.|.|. :||:  |....|:| |..|.|.|..:..|....|         |.||:.
Human    82 SGAQAQMDQNPGYYH-QLLQ--GERNPRLE-DAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLL 142

  Fly  1011 TYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFAN--MRSL 1073
            .|...:..|||.|||..:...|::|.::|..|:.....|:.|::.::.|...:.:....  :..|
Human   143 AYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGEL 207

  Fly  1074 IQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LA 1137
            ::.....:..||:..| ........|||:..|...|..:.|...|:.::     ..|..::| :|
Human   208 VRAKLPAVGALMERLG-VLWTLLVSRWFICLFVDILPVETVLRIWDCLF-----NEGSKIIFRVA 266

  Fly  1138 LALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSILQLSRSLVLQLQTIIE 1190
            |.|::.::::|| .:....|:...|.::.:           .|.|::..|.::
Human   267 LTLIKQHQELIL-EATSVPDICDKFKQITK-----------GSFVMECHTFMQ 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552
		TBC	947..1124	CDD:214540	43/179 (24%)
GRTP1	NP_001273661.1	TBC	65..278	CDD:214540	48/205 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900