DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG1695 and TBC1D17

DIOPT Version :9

Sequence 1:NP_728346.2 Gene:CG1695 / 33046 FlyBaseID:FBgn0031116 Length:1192 Species:Drosophila melanogaster
Sequence 2:NP_078958.2 Gene:TBC1D17 / 79735 HGNCID:25699 Length:648 Species:Homo sapiens


Alignment Length:207 Identity:71/207 - (34%)
Similarity:114/207 - (55%) Gaps:7/207 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly   983 IEKDVQRCDR-NYWYFANEN--LDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYS 1044
            ||:||.|.|| |.:|...||  |..|.:::.||...|.|:||:|||.||::|:|.:..:|..::.
Human   375 IERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFW 439

  Fly  1045 CFCKLMERMIENF-PSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRE 1108
            |||..||.:..|| .|...|......:..|:::||..:.|.:||. |.....||:||.|:.||||
Human   440 CFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQ-DSGSLCFCFRWLLIWFKRE 503

  Fly  1109 LVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQS 1173
            ..:.||...|||:|..  :...:..|.:|.|:|:..||.::.:.....:::|..||:..:.:.:.
Human   504 FPFPDVLRLWEVLWTG--LPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVED 566

  Fly  1174 ILQLSRSLVLQL 1185
            :|..:.:|..||
Human   567 VLTRAEALHRQL 578

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG1695NP_728346.2 RUN 63..237 CDD:280855
PH_RUTBC 310..485 CDD:275431
SRP68-RBD <648..>713 CDD:304552
TBC 947..1124 CDD:214540 58/144 (40%)
TBC1D17NP_078958.2 DUF3548 5..218 CDD:192931
Required for interaction with OPTN. /evidence=ECO:0000269|PubMed:22854040 218..309
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 240..259
TBC 307..542 CDD:214540 64/169 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 594..648
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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