DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1695 and Tbc1d9

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_001104774.1	Gene:	Tbc1d9 / 71310	MGIID:	1918560	Length:	1264	Species:	Mus musculus

Alignment Length:	810	Identity:	153/810 - (18%)
Similarity:	287/810 - (35%)	Gaps:	239/810 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   488 EEFLASHPILELGRSSP-----RRKHLGSCSTTGSSDC----SSKSLSIDQSSCETP---LIQAS 540
            ||.|.::.:....|::|     |||..|.....|....    .:..:.:|.|:...|   |.|..
Mouse     6 EEVLLANALWITERANPYFILQRRKGHGGDGGGGGGLAGLLVGTLDVVLDSSARVAPYRILYQTP 70

  Fly   541 QSTSI-ELVCSTMRRQIISRAFYGW--------LAYCRHLSTVRTHLSGLVNGRI-----MPDLA 591
            .|... .:.|...|:::...  :.|        |:...:.:.|.|.:.|.:.|.|     :.|:.
Mouse    71 DSLVYWTIACGGSRKEVTEH--WEWLEQNLLQTLSIFENENDVTTFVRGKIQGIIAEYNKINDVK 133

  Fly   592 ADE------EGLTR-GKWLAMHEDGVVTGDLELYRLVYFGGVEPELRKEVWPYL-LGHYDFGSTP 648
            .||      |.:.: .:...|.|:..:   :..|...|:.|..|   ::.|.|| :.|..|.|..
Mouse   134 EDEDTEKFKEAIVKFHRLFGMPEEEKL---VNYYSCSYWKGRVP---RQGWMYLSINHLCFSSFL 192

  Fly   649 EERKKQDETCKHYYETTMSEWLAVEAIVRQREKEKTALA--VAKLSAEQAR----LAANATSSSN 707
            ..|:.:          .:..|:.    :.|.||..|.|.  :.|:|...:.    :..|...:..
Mouse   193 MGREAK----------LVIRWVD----ITQLEKNATLLLPDMIKVSTRSSEHFFSVFLNINETFK 243

  Fly   708 PHQKLANGSQQLQLEHGNGEEDQENLVLDEGENDVFDDNDFSDISDPGDLFDEPELGQEAEEQEQ 772
            ..::|||.:.:..|::...|:|:....|.:              ..|..:   ..|.::.:.:.:
Mouse   244 LMEQLANIAMRQLLDNEGFEQDRSLPKLKK--------------KSPKKV---SALKRDLDARAK 291

  Fly   773 SNLEEEVFEKQEDEEDQEDHDQREMPRLSEKLVLEFQNIDNMEPLRLQEN--CFADSETENDLGL 835
            |.....:|...:||:.....|.        .|...|..:..:..:.:..|  ||...| ||...|
Mouse   292 SERYRALFRLPKDEKLDGHTDC--------TLWTPFNKMHILGQMFVSTNYICFTSKE-ENLCSL 347

  Fly   836 GLDSSGNILML----------SIKSSPSTSSYETVG-------------------NEFLDMAEAK 871
                   |:.|          |....||..|..|..                   ::||....::
Mouse   348 -------IIPLREVTIVEKADSCSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSR 405

  Fly   872 LEEEEPPGQLSKFHSADDVRLDNQDEEESSQPATAVIITEAASLDALDDDPTEEF--------TS 928
            :..::      :|..:    .::.|:|..|:|::.|..:...|..: |.|....|        |:
Mouse   406 IYSDK------EFSGS----CNSSDDEVYSRPSSLVSSSPQRSTSS-DADGERPFNLNGNSVPTA 459

  Fly   929 RKTSL-----MSPLNEDITVVASLDALQE------------------------------PK---- 954
            .:|.:     .||  |:.....:.:.|:|                              |:
Mouse   460 TQTLMTMYRRRSP--EEFNPKLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRG 522

  Fly   955 ------SACVSPASSNGGVYS--VE-LLEQFGLNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVI 1009
                  |..::..:::.|.|.  || .:.::.|....||:|:.|....:..|.|| .:..||.|:
Mouse   523 ELWLLLSGAINEKATHPGYYEGLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVL 587

  Fly  1010 STYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLI 1074
            :.|.:.:.::||.|.| ::|..:|:::..|..::.....|.|||:.:          :.|.|.:.
Mouse   588 TAYAFRNPNIGYCQAM-NIVTSVLLLYAKEEEAFWLLVALCERMLPD----------YYNTRVVG 641

  Fly  1075 QILDSEMYDLMDSNGDYT-HFYFCYR-----------WFL------LDFKRELVYDDVFATWEVI 1121
            .::|..:::  :...||. ..|.|.:           |||      :.|:..:|..|.|
Mouse   642 ALVDQGVFE--ELARDYVPQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCF------ 698

  Fly  1122 WAAKHIASGHFVLF-LALALLETYRDIILS 1150
                 ...|..|:| ||||:|:...|.:|:
Mouse   699 -----FYEGIKVIFQLALAVLDANVDKLLN 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552	10/70 (14%)
		TBC	947..1124	CDD:214540	45/238 (19%)
Tbc1d9	NP_001104774.1	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420	23/117 (20%)
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	19/110 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..456		10/56 (18%)
		TBC	512..722	CDD:214540	52/233 (22%)
		EFh	<893..923	CDD:298682
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1119..1162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900