DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1695 and Tbc1d10b

DIOPT Version :9

Sequence 1:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster
Sequence 2:	NP_653105.3	Gene:	Tbc1d10b / 68449	MGIID:	1915699	Length:	798	Species:	Mus musculus

Alignment Length:	384	Identity:	80/384 - (20%)
Similarity:	129/384 - (33%)	Gaps:	118/384 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   815 EPLRLQENCFADSETENDLGLGLDSSGNILMLSIKSSPSTSSYETVGNEFLDMAEAKLEEEEPPG 879
            ||:   || |.|..:.:.||.|:.....       .:|.|.||    .:.:.:....|  |..|.
Mouse   224 EPV---EN-FQDLGSTSSLGPGISGPRG-------QAPDTLSY----LDSVSLMSGTL--ESLPD 271

  Fly   880 QLSKFHSADDVR---LDNQDEE------------ESSQPATAVIITEAASLDALDDDPTEEFTSR 929
            .:|...|..::.   |...|:.            |||.|.......|...|:...:  .:::.||
Mouse   272 DVSSMGSDSEINGMALRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLEMFSN--WDKWLSR 334

  Fly   930 KTSLMSPLNEDITVVASLDALQEPKSACVS--PASSNGGVY-----SVELLEQFGLN-------- 979
            :                   .|:.|..|..  |:|.....:     |.|||||   |
Mouse   335 R-------------------FQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQ---NPGKFEELE 377

  Fly   980 --------LHRIEKDVQRCDRNYWYFA---NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLL 1033
                    |..||||:.|....:..||   ......|..::..|.....|.||.|....:.|.||
Mouse   378 RAAGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLL 442

  Fly  1034 VIFDDESLSYSCFCKLMERMIENFPSGGAM------DMHFANMRSLI---------QILDSEMYD 1083
            :....|. ::.|..::.::.:..:.|.|..      ::.||.:|.:.         |.:|..:|
Mouse   443 MHMPAEQ-AFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRVSPLAHRHLRRQRIDPVLY- 505

  Fly  1084 LMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALL 1141
                         ...||:..|.|.|.:..|...|::.:     ..|..::| :||.||
Mouse   506 -------------MTEWFMCIFARTLPWASVLRVWDMFF-----CEGVKIIFRVALVLL 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431
		SRP68-RBD	<648..>713	CDD:304552
		TBC	947..1124	CDD:214540	46/217 (21%)
Tbc1d10b	NP_653105.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	118..211
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	225..250		8/35 (23%)
		TBC	343..548	CDD:214540	50/227 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	618..798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900